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  3. JQ-1 carboxylic acid

JQ-1 carboxylic acid 

Cat. No.: HY-78695 Purity: 99.59%
Handling Instructions

JQ-1 carboxylic acid is a highly potent, selective and cell-permeable BRD4 inhibitor with IC50s of 77 nM and 33 nM for BRD4(1) and BRD4(2), respectively.

For research use only. We do not sell to patients.

JQ-1 carboxylic acid Chemical Structure

JQ-1 carboxylic acid Chemical Structure

CAS No. : 202592-23-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 145 In-stock
Estimated Time of Arrival: December 31
5 mg USD 132 In-stock
Estimated Time of Arrival: December 31
10 mg USD 204 In-stock
Estimated Time of Arrival: December 31
50 mg USD 432 In-stock
Estimated Time of Arrival: December 31
100 mg USD 720 In-stock
Estimated Time of Arrival: December 31
200 mg USD 1260 In-stock
Estimated Time of Arrival: December 31
500 mg USD 2700 In-stock
Estimated Time of Arrival: December 31
1 g USD 3300 In-stock
Estimated Time of Arrival: December 31
5 g USD 9480 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of JQ-1 carboxylic acid:

Top Publications Citing Use of Products

    JQ-1 carboxylic acid purchased from MCE. Usage Cited in: Nat Commun. 2018 Nov 19;9(1):4866.

    MYCN, PHOX2B, and TBX2 protein levels 10 h and 16 h upon treatment with 1 μM JQ1, 35 nM THZ1 and the combination of JQ1 and THZ1 in the IMR-5/75 cell line.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    JQ-1 carboxylic acid is a highly potent, selective and cell-permeable BRD4 inhibitor with IC50s of 77 nM and 33 nM for BRD4(1) and BRD4(2), respectively.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 155 mg/mL (386.65 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4945 mL 12.4726 mL 24.9451 mL
    5 mM 0.4989 mL 2.4945 mL 4.9890 mL
    10 mM 0.2495 mL 1.2473 mL 2.4945 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    400.88

    Formula

    C₁₉H₁₇ClN₄O₂S

    CAS No.

    202592-23-2

    SMILES

    ClC1=CC=C(C(C2=C(N3C4=NN=C3C)SC(C)=C2C)=N[[email protected]]4CC(O)=O)C=C1

    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 99.59%

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    Product Name:
    JQ-1 carboxylic acid
    Cat. No.:
    HY-78695
    Quantity:

    JQ-1 carboxylic acid

    Cat. No.: HY-78695