1. Epigenetics
  2. Epigenetic Reader Domain
  3. JQ-1 (carboxylic acid)

JQ-1 (carboxylic acid) 

Cat. No.: HY-78695 Purity: 99.59%
Handling Instructions

JQ-1 carboxylic acid is a (+)-JQ1 derivative (a BET bromodomain inhibitor). JQ-1 carboxylic acid can be uesd as a precursor to synthesize PROTACs, which targets BET bromodomains.

For research use only. We do not sell to patients.

JQ-1 (carboxylic acid) Chemical Structure

JQ-1 (carboxylic acid) Chemical Structure

CAS No. : 202592-23-2

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
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10 mg USD 100 In-stock
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50 mg USD 200 In-stock
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100 mg USD 300 In-stock
Estimated Time of Arrival: December 31
200 mg USD 450 In-stock
Estimated Time of Arrival: December 31
500 mg USD 950 In-stock
Estimated Time of Arrival: December 31
1 g USD 1650 In-stock
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5 g USD 5250 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of JQ-1 (carboxylic acid):

Top Publications Citing Use of Products

Publications Citing Use of MCE JQ-1 (carboxylic acid)

    JQ-1 (carboxylic acid) purchased from MCE. Usage Cited in: Nat Commun. 2018 Nov 19;9(1):4866.

    MYCN, PHOX2B, and TBX2 protein levels 10 h and 16 h upon treatment with 1 μM JQ1, 35 nM THZ1 and the combination of JQ1 and THZ1 in the IMR-5/75 cell line.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    JQ-1 carboxylic acid is a (+)-JQ1 derivative (a BET bromodomain inhibitor). JQ-1 carboxylic acid can be uesd as a precursor to synthesize PROTACs, which targets BET bromodomains[1].

    In Vitro

    (+)-JQ-1 is a potent, specific, and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)). (+)-JQ-1 also activates autophagy[2][3].

    Molecular Weight

    400.88

    Formula

    C₁₉H₁₇ClN₄O₂S

    CAS No.

    202592-23-2

    SMILES

    ClC1=CC=C(C(C2=C(N3C4=NN=C3C)SC(C)=C2C)=N[[email protected]]4CC(O)=O)C=C1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (249.45 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4945 mL 12.4726 mL 24.9451 mL
    5 mM 0.4989 mL 2.4945 mL 4.9890 mL
    10 mM 0.2495 mL 1.2473 mL 2.4945 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.59%

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    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    JQ-1 (carboxylic acid)Epigenetic Reader DomainchromatinremodelingpolypeptidebromodomainInhibitorinhibitorinhibit

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    Product name:
    JQ-1 (carboxylic acid)
    Cat. No.:
    HY-78695
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