Serine/Threonine Focused Covalent Fragment Library

Cat. No.: HY-L914

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In the research of covalent inhibitors targeting serine and threonine, scientists have found that the nucleophilicity of these hydroxyl groups is significantly enhanced due to the influence of their surrounding environment. This results in higher activity during catalytic reactions. Aspirin, which targets the non-catalytic domain serine (Ser529 in human COX1) of cyclooxygenase, exerts its anti-inflammatory effect through covalent binding. β-lactam antibiotics, which targets the catalytic domain serine of penicillin-binding proteins, interferes with bacterial cell wall synthesis.

Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 3,300 fragment molecules which can target serine and threonine residues and can be used for fragment-based covalent drug discovery.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, and 2 mM for compounds with solubility between 2 mM and 10 mM.

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Biological Activity
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Composition

Description & Advantages

• A unique collection of 3,300 Fragments that show covalent binding with serine/threonine.

• Careful selection of warheads: only those with experimentally validated reactivity are chosen, avoiding over-reactive warheads and any alternative reactive functionalities.

• A useful tool for the fragment-based approach to drug discovery (FBDD).

• All compounds are available off the shelf.

• LCMS or NMR validated to ensure high purity and quality.

Product Details

Formulation:

This fragment library containing 3,300 fragments with warheads targeting serine and threonine residues.
Solution: 3,203 compounds supplied in 10 mM solution, 1 compounds supplied in 2 mM solution.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice or dry ice

Documentation

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Library Handling Instructions (351 KB)

Composition

Biochemical Assay Reagents (116)

Drug Intermediate (30)

PROTAC Linkers (9)

MOFs (7)

Reactive Oxygen Species (ROS) (4)

Apoptosis (2)

Fluorescent Dye (2)

Fungal (2)

Akt (1)

Amyloid-β (1)

Antibiotic (1)

Bacterial (1)

Calcium Channel (1)

Carbonic Anhydrase (1)

Carnitine Palmitoyltransferase (CPT) (1)

Caspase (1)

Drug Derivative (1)

Endogenous Metabolite (1)

Environmental Pollutants (1)

ERK (1)

FAAH (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Isotope-Labeled Compounds (1)

JNK (1)

Mitochondrial Metabolism (1)

Mitophagy (1)

Monoamine Oxidase (1)

NF-κB (1)

p38 MAPK (1)

PAI-1 (1)

PI3K (1)

PPAR (1)

SARS-CoV (1)

Ser/Thr Protease (1)

Sodium Channel (1)

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