1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Ephrin/Eph Family

Ephrins are a family of ligands that bind to the Eph receptors, the largest family of receptor tyrosine kinases. Ephrins and the Eph family are membrane-bound molecules that mediate short-range axon guidance via cell-cell contacts. The ephrins fall into two broad classes, the ephrinAs (ephrins A1-A6), which are attached to the cell membrane by a glycosyl phosphatidylinositol (GPI) moiety, and the ephrinBs (ephrins B1-B3), which span the cellular membrane and possess a cytoplasmic signaling domain. In the human genome, there are totally nine EphA and five EphB receptors. The EphA receptors promiscuously bind to five Ephrin-A ligands, and the EphB receptors promiscuously bind three Ephrin-B ligands. Ephrin-Eph signaling is bidirectional which is termed forward signaling in Eph receptor-expressing cells and reverse signaling in ephrin ligand-expressing cells. The Eph/ephrin signaling plays important roles in developmental processes, adult tissue homeostasis and various diseases. Its abnormal function has been implicated in various diseases, including cancer. Given Eph receptors and Ephrins are often overexpressed in human malignancies and associated with poor prognosis, they are considered as very promising drug targets.

Cat. No. Product Name / Synonyms Species Source
  • HY-P70164
    Ephrin-A1/EFNA1 Protein, Human (AAH32698.1, HEK293, His)

    rHuEphrin-A1, His; Ephrin-A1; EPH-Related Receptor Tyrosine Kinase Ligand 1; LERK-1; Immediate Early Response Protein B61; Tumor Necrosis Factor Alpha-Induced Protein 4; TNF Alpha-Induced Protein 4; EFNA1; EPLG1; LERK1; TNFAIP4

    Human HEK293
    Ephrin-A1/EFNA1 Protein is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family (EphA2). EFNA1 exerts its function largely through interactions with EphA2. EFNA1 exists in a soluble form as well as a glycophosphatidylinositol (GPI) membrane attached form. EFNA1 acts as a membrane-bound, GPI-anchored protein capable of mediating juxtacrine signalling and requiring membrane attachment or clustering/oligomerization. EFNA1 is a novel TNF-inducible protein. EFNA1 efficiently binds to the EphA8 receptor expressed in NIH3T3 fibroblasts. EFNA1 stimulates PI3K activity via direct interaction of EphA2 with the p85 subunit of PI3K. EFNA1 can both inhibit and stimulate oncogenesis, depending on the cellular context. Ephrin-A1/EFNA1 Protein, Human (AAH32698.1, HEK293, His) is the recombinant human-derived Ephrin-A1/EFNA1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Ephrin-A1/EFNA1 Protein, Human (AAH32698.1, HEK293, His) is 164 a.a., with molecular weight of 25-30 kDa.
  • HY-P72991
    EphA2 Protein, Human (sf9, His-GST)

    Ephrin type-A receptor 2; Epithelial cell kinase; EPHA2; ECK

    Human Sf9 insect cells
    EphA2 protein is a receptor tyrosine kinase that participates in bidirectional signaling with various ephrin A ligands, affecting cell migration, adhesion, proliferation and differentiation. It regulates cell adhesion and differentiation by interacting with DSG1 and inhibiting the ERK1/ERK2 signaling pathway. EphA2 Protein, Human (sf9, His-GST) is the recombinant human-derived EphA2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of EphA2 Protein, Human (sf9, His-GST) is 392 a.a., with molecular weight of ~62 kDa.
  • HY-P72992
    EphA2 Protein, Human (Biotinylated, HEK293, His-Avi)

    Ephrin type-A receptor 2; Epithelial cell kinase; EPHA2; ECK

    Human HEK293
    The EphA2 protein is an important member of the ephrin receptor subfamily that mediates developmental events, particularly in the nervous system. It has a single kinase domain and an extracellular region that binds ephrin-A ligands. EphA2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived EphA2 protein, expressed by HEK293 , with C-6*His, C-Avi labeled tag. The total length of EphA2 Protein, Human (Biotinylated, HEK293, His-Avi) is 511 a.a., with molecular weight of ~59.4 kDa.
  • HY-P73001
    EphB2 Protein, Human (HEK293, His-Fc)

    EPHB2; Ephrin type-B receptor 2; EK5; DRT; EPHT3; ERK; HEK5; TYRO5

    Human HEK293
    EphB2 protein is a receptor tyrosine kinase that participates in bidirectional signaling with the transmembrane ephrin B ligand. It guides commissural axons in the developing cerebral cortex, efferent growth cones of the inner ear, and retinal ganglion cell axons. EphB2 Protein, Human (HEK293, His-Fc) is the recombinant human-derived EphB2 protein, expressed by HEK293 , with C-hFc, C-8*His labeled tag. The total length of EphB2 Protein, Human (HEK293, His-Fc) is 525 a.a., with molecular weight of approximately 95 kDa.
  • HY-P73005
    EphB4 Protein, Mouse (HEK293, His)

    Ephrin type-B receptor 4; EPHB4; HTK; MYK1; TYRO11

    Mouse HEK293
    Ephb4 Protein, a receptor tyrosine kinase, plays a critical role in angiogenesis and development. Dysregulation of Ephb4 Protein has been associated with disorders like cancer and cardiovascular diseases. Targeting Ephb4 Protein may provide potential therapeutic interventions in these conditions by modulating angiogenesis, inhibiting tumor growth, and managing cardiovascular complications. EphB4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphB4 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphB4 Protein, Mouse (HEK293, His) is 524 a.a., with molecular weight of ~75 kDa.
  • HY-P75749
    EphB3 Protein, Mouse (537a.a, HEK293, His)

    Ephrin type-B receptor 3; mDK-5; Tyrosine-protein kinase receptor SEK-4; Sek4

    Mouse HEK293
    The EphB3 protein is a receptor tyrosine kinase that binds to the transmembrane ephrin B ligand to initiate bidirectional signaling. The forward signal originates from the receptor, while the reverse signal originates from the ephrin ligand. EphB3 Protein, Mouse (537a.a, HEK293, His) is the recombinant mouse-derived EphB3 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphB3 Protein, Mouse (537a.a, HEK293, His) is 537 a.a., with molecular weight of ~63 kDa.
  • HY-P70336
    EphA2 Protein, Human (HEK293, His)

    rHuEphrin type-A receptor 2/EphA2, His; Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK; EPHA2

    Human HEK293
    EphA2 protein is a receptor tyrosine kinase that participates in bidirectional signaling with various ephrin A ligands, affecting cell migration, adhesion, proliferation and differentiation. It regulates cell adhesion and differentiation by interacting with DSG1 and inhibiting the ERK1/ERK2 signaling pathway. EphA2 Protein, Human (HEK293, His) is the recombinant human-derived EphA2 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA2 Protein, Human (HEK293, His) is 511 a.a., with molecular weight of 65-75 kDa.
  • HY-P70377
    Ephrin-B2/EFNB2 Protein, Human (HEK293, His)

    rHuEphrin-B2/EFNB2, His; Ephrin-B2; EPH-Related Receptor Tyrosine Kinase Ligand 5; LERK-5; HTK Ligand; HTK-L; EFNB2; EPLG5; HTKL; LERK5

    Human HEK293
    Ephrin-B2/EFNB2 is a key transmembrane ligand of Eph receptors that coordinates migration, repulsion, and adhesion in developing neurons, blood vessels, and epithelia. It induces bidirectional signaling, binding to EPHA4, EPHA3 and EPHB4, which is critical for cardiac morphogenesis and angiogenesis. Ephrin-B2/EFNB2 Protein, Human (HEK293, His) is the recombinant human-derived Ephrin-B2/EFNB2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Ephrin-B2/EFNB2 Protein, Human (HEK293, His) is 202 a.a., with molecular weight of 30-40 kDa.
  • HY-P72995
    EphA4 Protein, Mouse (HEK293, Fc)

    Ephrin type-A receptor 4; EPH-like kinase 8; EK8; EPHA4; HEK8; SEK; TYRO1

    Mouse HEK293
    The EphA4 protein is a receptor tyrosine kinase that participates in contact-dependent bidirectional signaling with ephrin A and ephrin B ligands. EphA4 is activated by GPI-anchored EFNA and transmembrane EFNB and regulates cell morphology, integrin-dependent adhesion, and GTPase activity. EphA4 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EphA4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphA4 Protein, Mouse (HEK293, Fc) is 528 a.a., with molecular weight of ~110 kDa.
  • HY-P73009
    Ephrin-A3/EFNA3 Protein, Mouse (HEK293, His)

    Ephrin-A3; EFL-2; EHK1-L; LERK-3; EFNA3; EFL2; EPLG3

    Mouse HEK293
    Ephrin-A3/EFNA3 Protein, a GPI-bound ligand, interacts with Eph receptors, playing a critical role in neuronal, vascular, and epithelial development. It binds adjacent Eph receptors, initiating bidirectional signaling. Ephrin-A3/EFNA3 also activates EPHA8, contributing to its regulatory functions in migration, repulsion, and adhesion. Ephrin-A3/EFNA3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Ephrin-A3/EFNA3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Ephrin-A3/EFNA3 Protein, Mouse (HEK293, His) is 183 a.a., with molecular weight of ~38 kDa.
  • HY-P75228
    Ephrin B3 Protein, Mouse (HEK293, His)

    EFNB3; EPH-related receptor tyrosine kinase ligand 8; Ephrin B3; LERK-8; ELK-L3

    Mouse HEK293
    Ephrin B3 protein, a transmembrane ligand, binds adjacent Eph receptors, triggering bidirectional signaling. It induces axon collapse in vitro and may influence axon guidance and orientation. Ephrin B3 interacts with GRIP1 and GRIP2, suggesting regulatory roles in development and cellular functions. Ephrin B3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Ephrin B3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Ephrin B3 Protein, Mouse (HEK293, His) is 200 a.a., with molecular weight of ~23.5 kDa.
  • HY-P75236
    EphB2 Protein, Mouse (HEK293, Fc)

    EPHB2; Ephrin type-B receptor 2; EK5; DRT; EPHT3; ERK; HEK5; TYRO5

    Mouse HEK293
    EphB2 protein is a member of the Eph receptor family and has a ligand-binding domain, a transmembrane region, and an intracellular kinase domain. It preferentially binds ephrin-B ligands and plays a role in nervous system and vascular development. EphB2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EphB2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EphB2 Protein, Mouse (HEK293, Fc) is 522 a.a., with molecular weight of ~96.6 kDa.
  • HY-P75238
    EphA4 Protein, Rat (HEK293, His)

    Ephrin type-A receptor 4; EPH-like kinase 8; EK8; EPHA4; HEK8; SEK; TYRO1

    Rat HEK293
    EphA4 Protein, a receptor tyrosine kinase, engages in contact-dependent bidirectional signaling with ephrin-A and ephrin-B ligands. Activated by GPI-anchored EFNA and transmembrane EFNB, EphA4 regulates cell morphology, integrin-dependent adhesion, and GTPase activity. Crucial in nervous system development, it guides axonal projections, segregates motor and sensory axons, and influences synaptic plasticity. In injury repair and angiogenesis, EphA4 inhibits axonal regeneration and contributes to vascular formation. Its promiscuity extends to thymic epithelium development, cochlear organ of Corti formation, and phosphorylation of CAPRIN1 for membraneless compartment formation. EphA4 Protein, Rat (HEK293, His) is the recombinant rat-derived EphA4 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA4 Protein, Rat (HEK293, His) is 528 a.a., with molecular weight of ~70-80 kDa.
  • HY-P75240
    EphA2 Protein, Mouse (HEK293, His)

    Ephrin type-A receptor 2; Epithelial cell kinase; EPHA2; ECK

    Mouse HEK293
    EphA2 protein is a receptor tyrosine kinase that promiscuously binds to ephrin A ligands to initiate bidirectional signaling. EphA2 is activated by ephrin-A1/EFNA1, regulates cell migration, adhesion, proliferation and differentiation, modulates DSG1 and inhibits ERK1/ERK2 signaling. EphA2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphA2 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA2 Protein, Mouse (HEK293, His) is 510 a.a., with molecular weight of ~65-95 kDa.
  • HY-P75241
    EphA1 Protein, Mouse (HEK293, His)

    Ephrin type-A receptor 1; hEpha1; EPHA1; EPH; EPHT; EPHT1

    Mouse HEK293
    The EphA1 protein is a receptor tyrosine kinase that promiscuously binds to ephrin-A ligands on neighboring cells, initiating contact-dependent bidirectional signaling. The forward signal originates from the receptor and the reverse signal originates from the ephrin ligand. EphA1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphA1 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA1 Protein, Mouse (HEK293, His) is 522 a.a., with molecular weight of ~68 kDa.
  • HY-P75745
    EphA6 Protein, Mouse (HEK293, His)

    Ephrin type-A receptor 6; EPH homology kinase 2; EHK-2; Epha6

    Mouse HEK293
    EphA6 Protein, a receptor tyrosine kinase, engages in promiscuous binding with GPI-anchored ephrin-A ligands, facilitating contact-dependent bidirectional signaling. EphA6 mediates intricate signaling exchanges between cells, playing a crucial role in diverse cellular processes through both forward and reverse signaling pathways. EphA6 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphA6 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA6 Protein, Mouse (HEK293, His) is 524 a.a., with molecular weight of ~65-70 kDa.
  • HY-P75746
    EphA7 Protein, Mouse (HEK293, His)

    Ephrin Type-A Receptor 7; mDK-1; EHK-3; EBK

    Mouse HEK293
    The EphA7 protein is a receptor tyrosine kinase that participates in bidirectional signaling with GPI-anchored ephrin-A ligands (especially EFNA5). It affects brain development by regulating intercellular adhesion and repulsion, contributing to axonal guidance of corticothalamic and retinal axons. EphA7 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphA7 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA7 Protein, Mouse (HEK293, His) is 529 a.a., with molecular weight of 68-77 kDa.
  • HY-P75748
    EphB1 Protein, Mouse (HEK293, His)

    Ephrin type-B receptor 1; ELK; EK6; NET; EPHB1; EPHT2; HEK6

    Mouse HEK293
    EphB1 protein is a receptor tyrosine kinase that participates in bidirectional signaling with ephrin B ligands (including EFNB1, EFNB2, and EFNB3). It plays a crucial role in retinal axon guidance, neural progenitor cell regulation, dendritic spine maturation, synapse formation, angiogenesis, targeted cell migration, and muscle stem cell maintenance. EphB1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphB1 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphB1 Protein, Mouse (HEK293, His) is 522 a.a., with molecular weight of ~65-75 kDa.
  • HY-P77356
    EFNB2A Protein, zebrafish (HEK293, His)

    Ephrin-B2a; efnb2

    Others HEK293
    The EFNB2A protein is a cell surface ligand of the Eph receptor that critically regulates migration, repulsion, and adhesion in neuronal, vascular, and epithelial development. EFNB2A Protein, zebrafish (HEK293, His) is the recombinant EFNB2A protein, expressed by HEK293 , with C-His labeled tag. The total length of EFNB2A Protein, zebrafish (HEK293, His) is 198 a.a., with molecular weight of ~30-40 kDa.
  • HY-P700609
    Ephrin-B1/EFNB1 Protein, Human (HEK293, C-hFc)

    Ephrin-B1; EFL-3; ELK-L; LERK-2; Ephrin-B1 CTF; EFNB1; EFL3; EPLG2; LERK2

    Human HEK293
    Ephrin-B1/EFNB1 Protein, a type I membrane protein, acts as a ligand for Eph-related receptor tyrosine kinases, potentially influencing cell adhesion and contributing to nervous system development. With ubiquitous expression, it is notably present in fat, placenta, and various tissues, showcasing its broad impact on diverse cellular and physiological contexts. Ephrin-B1/EFNB1 Protein, Human (HEK293, C-hFc) is the recombinant human-derived Ephrin-B1/EFNB1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Ephrin-B1/EFNB1 Protein, Human (HEK293, C-hFc) is 210 a.a., with molecular weight of approximately 58.76 kDa.
Cat. No. Product Name Effect Purity