EphA2
EphA2 is among the most intensively studied Eph receptors because of its dual behavior in cancer. Expressed on many epithelia, it binds ephrin-A1 and ephrin-A5; ligand-dependent activation typically induces receptor internalization, cytoskeletal collapse and growth-suppressive signaling, whereas in tumors EphA2 is often overexpressed and phosphorylated at Ser897 by Akt in a ligand-independent manner that promotes migration, invasion and angiogenesis. High EphA2 levels correlate with poor prognosis in glioblastoma, breast, prostate, lung and ovarian cancers, and the receptor is being pursued with monoclonal antibodies, antibody-drug conjugates and CAR-T approaches. Recombinant EphA2 proteins are core reagents for these targeting and signaling studies.
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EphA2 Protéines Recombinantes (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
