1. Recombinant Proteins
  2. Cytokines and Growth Factors Receptor Proteins Enzymes & Regulators
  3. Ephrin/Eph Family Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. Eph Receptors
  5. EphA2
  6. EphA2 Protein, Cynomolgus (HEK293, hFc)

EphA2 Protein, Cynomolgus (HEK293, hFc)

Cat. No.: HY-P700712
Handling Instructions

EphA2 Protein, a receptor tyrosine kinase, engages in bidirectional signaling with ephrin-A ligands, influencing migration, adhesion, proliferation, and differentiation. EphA2 interacts with DSG1, inhibiting ERK1/ERK2 signaling, impacting cell adhesion and UV radiation-induced apoptosis. In development, EphA2 contributes to pattern formation, angiogenesis, hindbrain development, and mammary gland morphogenesis. Its interaction with Ephrin-A5 maintains lens transparency, and in bone remodeling, it regulates osteoclastogenesis and osteoblastogenesis through Ephrin-A2 interaction. EphA2 also acts as a receptor for hepatitis C virus in hepatocytes, facilitating viral entry and membrane fusion. EphA2 Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived EphA2 protein, expressed by HEK293, with C-hFc labeled tag. The total length of EphA2 Protein, Cynomolgus (HEK293, hFc) is 511 a.a., with molecular weight of 90-100 kDa.

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Description

EphA2 Protein, a receptor tyrosine kinase, engages in bidirectional signaling with ephrin-A ligands, influencing migration, adhesion, proliferation, and differentiation. EphA2 interacts with DSG1, inhibiting ERK1/ERK2 signaling, impacting cell adhesion and UV radiation-induced apoptosis. In development, EphA2 contributes to pattern formation, angiogenesis, hindbrain development, and mammary gland morphogenesis. Its interaction with Ephrin-A5 maintains lens transparency, and in bone remodeling, it regulates osteoclastogenesis and osteoblastogenesis through Ephrin-A2 interaction. EphA2 also acts as a receptor for hepatitis C virus in hepatocytes, facilitating viral entry and membrane fusion. EphA2 Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived EphA2 protein, expressed by HEK293, with C-hFc labeled tag. The total length of EphA2 Protein, Cynomolgus (HEK293, hFc) is 511 a.a., with molecular weight of 90-100 kDa.

Background

EphA2 Protein is a receptor tyrosine kinase that interacts with membrane-bound ephrin-A ligands on adjacent cells, resulting in contact-dependent bidirectional signaling. This receptor mediates both forward signaling and reverse signaling pathways. Activation by ephrin-A1/EFNA1 regulates various cellular processes, including migration, integrin-mediated adhesion, proliferation, and differentiation. EphA2 also influences cell adhesion and differentiation through its interaction with DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 signaling pathway. Additionally, it may play a role in UV radiation-induced apoptosis and stimulate chemotactic cell migration independently of ligand binding. During development, EphA2 is involved in pattern formation and contributes to the development of fetal tissues, such as angiogenesis, hindbrain development, and mammary gland morphogenesis. Its interaction with ephrin-A5/EFNA5 is crucial for maintaining lens transparency by regulating the shape and interactions of lens fiber cells. Furthermore, EphA2 participates in bone remodeling by regulating osteoclastogenesis and osteoblastogenesis through its interaction with ephrin-A2/EFNA2.

Species

Cynomolgus

Source

HEK293

Tag

C-hFc

Accession

Q1KL86 (A24-S534)

Gene ID

102146108  [NCBI]

Molecular Construction
N-term
EphA2 (A24-S534)
Accession # Q1KL86
hFc
C-term
Synonyms
Ephrin type-A receptor 2 ; EC:2.7.10.1; EPHA2
Molecular Weight

90-100 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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EphA2 Protein, Cynomolgus (HEK293, hFc)
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HY-P700712
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