RIG-I-like Receptor
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are a family of cytosolic pattern recognition receptors (PRRs) that recognize viral RNA and result in immunological response. RLRs include RIG-I (retinoic acid-inducible gene I), MDA5 (melanoma differentiation associated factor 5), and LGP2 (laboratory of genetics and physiology 2). They share a number of structural similarities including their organization into three distinct domains: 1) An N-terminal region consisting of tandem caspase activation and recruitment domains (CARD); 2) A central DExD/H box RNA helicase domain with the capacity to hydrolyze ATP and to bind RNA; 3) A repressor domain (RD) embedded within the carboxy-terminal domain (CTD). LGP2 lacks the CARDs and is widely thought to function as a regulator of RIG-I and MDA5. Upon RNA binding and oligomerization, RLRs interact with mitochondrial antiviral-signalling protein (MAVS) via CARD–CARD interactions. Activated MAVS then activates TANK-binding kinase 1 (TBK1) and IκB kinase-ε (IKKε), which phosphorylates IRF3 and IRF7; these, together with nuclear factor-κB (NF-κB), then induce transcription of the genes encoding type I interferons and other antiviral or immunoregulatory genes.
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RIG-I-like Receptor Recombinant Proteins (1)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
