Signaling Pathway

FAAH

FAAH

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FAAH (Fatty acid amide hydrolase) is an integral membrane enzyme that degrades the fatty acid amide family of signaling lipids, including the endocannabinoid anandamide. Genetic or pharmacological inactivation of FAAH leads to analgesic, anti-inflammatory, anxiolytic, and antidepressant phenotypes in rodents without showing the undesirable side effects observed with direct cannabinoid receptor agonists, indicating that FAAH may represent an attractive therapeutic target for treatment of pain, inflammation, and other central nervous system disorders.

FAAH Inhibitors & Modulators (10)

Product Name Catalog No. Brief Description
BIA 10-2474

HY-19740

BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC50 values of 50 to 70mg/kg in various rat brain regions.

Biochanin A

HY-14595

Biochanin A(Olmelin), an O-methylated isoflavone, is a natural organic compound in the class of phytochemicals known as flavonoids; inhibit FAAH with IC(50) values of 1.8/1.4/2.4 uM for mouse/Rat/Human FAAH respectively.

FAAH inhibitor 1

HY-10862

FAAH inhibitor 1 is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 18±8 nM.

FAAH-IN-2

HY-79511

FAAH-IN-2 is a potent FAAH(fatty acid amide hydrolase) inhibitor extracted from Patent WO/2008/100977A2.

JNJ-42165279

HY-19636

JNJ-42165279 is a FAAH inhibitor with IC50 of 70 ± 8 nM and 313 ± 28 nM for hFAAH and rFAAH, respectively.

JZL195

HY-15250

JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.

LY2183240

HY-10865

LY2183240 is a novel and highly potent blocker of anandamide uptake (IC50 = 270 pM).

PF-04457845

HY-14376

PF-04457845 is a potent and exquisitely selective inhibitor of FAAH, with an IC50 of 7.2 nM, and both analgesic and antiinflammatory effects in animal studies comparable to naproxen.

PF-3845

HY-14380

PF-3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23 μM); showing negligible activity against FAAH2.

URB-597

HY-10864

URB597 is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets.