2. AM404

AM404, an inhibitor of endocannabinoid reuptake, blocks anandamide transport with IC50 values in the low micromolar range. AM404 is able to relax rat isolated hepatic arteries contracted with Phenylephrine, with a pEC50 value of 7.4 (corresponding to an EC50 of 0.04 µM). Neuroprotective Effect.

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AM404 Chemical Structure

AM404 Chemical Structure

CAS No. : 183718-77-6

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5 mg（126.4 mM * 100 μL in Ethanol） USD 70 Ask For Quote & Lead Time
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10 mg（126.4 mM * 200 μL in Ethanol） USD 110 Ask For Quote & Lead Time
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AM404 Related Antibodies

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1 Publications Citing Use of MCE AM404

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Description

AM404, an inhibitor of endocannabinoid reuptake, blocks anandamide transport with IC50 values in the low micromolar range[1]. AM404 is able to relax rat isolated hepatic arteries contracted with Phenylephrine, with a pEC50 value of 7.4 (corresponding to an EC50 of 0.04 µM). Neuroprotective Effect[2].

In Vitro

AM404 reduces C6 glioma cell proliferation with IC50 values of 4.9 µM. AM404 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AM404 Related Antibodies

Cell Viability Assay[2]

Cell Line: Rat C6 glioma cells
Concentration: 1, 3, 10 and 30 µM
Incubation Time: 24, 48, 72 and 96 h
Result: Produced a concentration-dependent reduction in cell proliferation that was seen with 24 h of exposure to 10 and 30 µM concentrations and after 48 h at 3 µM. The lowest concentration of AM404 tested, 1 µM, produced a significant, albeit small, reduction in cell proliferation at 72 h.
In Vivo

AM404 (1-5 mg/kg, i.p.) exerts dose-dependent anxiolytic-like effects in the three models: elevated plus maze, defensive withdrawal and separation-induced ultrasonic vocalizations.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats (250-300 g)[2]
Dosage: 2.5-10 mg/kg
Administration: Intraperitoneal (i.p.)
Result: Caused a dose-dependent increase in anandamide levels in prefrontal cortex, hippocampus and thalamus.
Molecular Weight

395.58

Formula

C26H37NO2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(NC1=CC=C(O)C=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: ≥99.0%

COA (237 KB)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM404183718-77-6AM 404AM-404Inhibitorinhibitorinhibit

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