2. Recombinant Proteins
  3. Receptor Proteins
  4. Pattern Recognition Receptors
  5. AIM2-like receptors

AIM2-like receptors

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Absent in melanoma 2 (AIM2)-like receptors (ALRs) are a family of pathogen recognition receptors (PRRs) involved in cytosolic and nuclear pathogen DNA recognition. Structurally, ALRs are characterized by a Pyrin signaling domain and a DNA-binding HIN domain. Interestingly, the ALR locus is highly variable in different species, For example, humans have 4 ALRs (AIM2, IFI16, PYHIN1, and MNDA), while mice have 13 or 14, including Aim2, p202, p203, p204, p205, p207, pyhin1, and cows have a single ALR. The best characterized ALR is AIM2 (absent in melanoma 2), the intracellular DNA sensor which signals via the adaptor protein ASC (Apoptosis-associated speck-like protein containing a CARD), to activate the inflammasome, a key arm of the innate immune system.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70713
    NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Flag)

    NKG2A& CD94 Heterodimer; KLRC1& CD94 Heterodimer; CD159A& KLRD1 Heterodimer

    		Human HEK293
    NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Flag) is a recombinant protein dimer complex containing human-derived NKG2A-CD94 Heterodimer protein, expressed by HEK293, with N-Flag, N-8*His labeled tag. NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Flag), has molecular weight of 25-40 kDa.
  • HY-P72700
    CD94 Protein, Human (HEK293, His)

    Natural killer cells antigen CD94; KP43; CD94; KLRD1

    		Human HEK293
    CD94 protein is a key immune receptor for self-non-self discrimination. It forms a complex with KLRC1 or KLRC2 on lymphocyte subsets and recognizes HLA-E loaded with self-peptides. It allows cytotoxic cells to monitor MHC class I expression and promote self-tolerance. CD94 Protein, Human (HEK293, His) is the recombinant human-derived CD94 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of CD94 Protein, Human (HEK293, His) is 146 a.a., with molecular weight of 23-28 kDa.
  • HY-P78097
    CD94 Protein, Human (Biotinylated, HEK293, His-Avi)

    CD94; KLRD1; KP43; NK cell receptor

    		Human HEK293
    CD94 protein is a key immune receptor for self-non-self discrimination. It forms a complex with KLRC1 or KLRC2 on lymphocyte subsets and recognizes HLA-E loaded with self-peptides. It allows cytotoxic cells to monitor MHC class I expression and promote self-tolerance. CD94 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD94 protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of CD94 Protein, Human (Biotinylated, HEK293, His-Avi) is 146 a.a., with molecular weight of 35-45 kDa.
  • HY-P77808
    NKG2A-CD94 Heterodimer Protein, Mouse (HEK293, mFc)

    CD159a; NKG2A; NKG2-A; CD94; NKG2A&CD94

    		Mouse HEK293
  • HY-P72816
    AIM2 Protein, Human (sf9, GST)

    Interferon-inducible protein AIM2; Absent in melanoma 2; AIM2

    		Human Sf9 insect cells
    AIM2 Protein, a member of the IFI20X/IFI16 family, exhibits potential regulatory functions in cell proliferation and tumorigenic reversion. Induced by interferon-gamma, AIM2 plays a key role in immune responses. Notably expressed in tissues like lymph node and appendix, AIM2 is a significant player in diverse cellular processes and immune-related functions. AIM2 Protein, Human (sf9, GST) is the recombinant human-derived AIM2 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of AIM2 Protein, Human (sf9, GST) is 343 a.a., with molecular weight of ~65.2 kDa.
  • HY-P77803
    NKG2A-CD94 Heterodimer Protein, Human (HEK293, Fc-Flag)

    CD159a; NKG2A; NKG2-A; CD94; NKG2A&CD94

    		Human HEK293
    NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A-CD94 Heterodimer Protein, Human (HEK293, Fc-Flag) is a recombinant protein dimer complex containing human-derived NKG2A-CD94 Heterodimer protein, expressed by HEK293, with N-hFc, N-Flag labeled tag. NKG2A-CD94 Heterodimer Protein, Human (HEK293, Fc-Flag), has molecular weight of 55-65 kDa.
  • HY-P77804
    NKG2A-CD94 Heterodimer Protein, Human (HEK293, mFc)

    CD159a; NKG2A; NKG2-A; CD94; NKG2A&CD94

    		Human HEK293
    NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A-CD94 Heterodimer Protein, Human (HEK293, mFc) is a recombinant protein dimer complex containing human-derived NKG2A-CD94 Heterodimer protein, expressed by HEK293, with C-mFc labeled tag. NKG2A-CD94 Heterodimer Protein, Human (HEK293, mFc), has molecular weight of 70-90 kDa.
  • HY-P77805
    NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Avi)

    CD159a; NKG2A; NKG2-A; CD94; NKG2A&CD94

    		Human HEK293
    NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived NKG2A-CD94 Heterodimer protein, expressed by HEK293, with N-His, N-Avi labeled tag. NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Avi), has molecular weight of 33-48 kDa.
  • HY-P77806
    NKG2A-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi)

    CD159a; NKG2A; NKG2-A; CD94; NKG2A&CD94

    		Human HEK293
    NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived NKG2A-CD94 Heterodimer protein, expressed by HEK293, with N-His, N-Avi labeled tag. NKG2A-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 33-48 kDa.
  • HY-P77807
    NKG2C-CD94 Heterodimer Protein, Human (HEK293, His-Avi)

    NKG2C&CD94

    		Human HEK293
    NKG2C/CD159c Protein, an immune activating receptor, crucially contributes to self-nonself discrimination. Partnering with KLRD1, it recognizes non-classical MHC class Ib HLA-E loaded with peptides from HLA-G, impacting adaptive NK cell functions and maternal-fetal tolerance. NKG2C/CD159c regulates terminally differentiated cytotoxic lymphocytes, particularly in adaptive NK cell responses to viral infection. Upon binding to HLA-E-peptide complexes, it transmits intracellular signals via TYROBP/DAP12, initiating cell activation. The multifaceted interactions highlight its essential role in immune responses and self-tolerance mechanisms. NKG2C-CD94 Heterodimer Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived NKG2C-CD94 Heterodimer protein, expressed by HEK293, with N-His, N-Avi labeled tag. NKG2C-CD94 Heterodimer Protein, Human (HEK293, His-Avi), has molecular weight of 30-50 kDa.
  • HY-P700796
    NKG2A-CD94 Heterodimer Protein, Cynomolgus (HEK293, His-Flag)

    CD159a; NKG2A; NKG2-A; CD94; NKG2A&CD94

    		Cynomolgus HEK293
  • HY-P78421
    CD94 Protein, Human (HEK293, His-Avi)

    CD94; KLRD1; KP43; NK cell receptor

    		Human HEK293
    CD94 protein is a key immune receptor for self-non-self discrimination. It forms a complex with KLRC1 or KLRC2 on lymphocyte subsets and recognizes HLA-E loaded with self-peptides. It allows cytotoxic cells to monitor MHC class I expression and promote self-tolerance. CD94 Protein, Human (HEK293, His-Avi) is the recombinant human-derived CD94 protein, expressed by HEK293 , with N-Avi, N-His labeled tag. The total length of CD94 Protein, Human (HEK293, His-Avi) is 146 a.a., with molecular weight of 38-42 kDa.
  • HY-P700797
    NKG2C-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi)

    NKG2C&CD94; NKG2C; CD94

    		Human HEK293
    NKG2C/CD159c Protein, an immune activating receptor, crucially contributes to self-nonself discrimination. Partnering with KLRD1, it recognizes non-classical MHC class Ib HLA-E loaded with peptides from HLA-G, impacting adaptive NK cell functions and maternal-fetal tolerance. NKG2C/CD159c regulates terminally differentiated cytotoxic lymphocytes, particularly in adaptive NK cell responses to viral infection. Upon binding to HLA-E-peptide complexes, it transmits intracellular signals via TYROBP/DAP12, initiating cell activation. The multifaceted interactions highlight its essential role in immune responses and self-tolerance mechanisms. NKG2C-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived NKG2C-CD94 Heterodimer protein, expressed by HEK293, with C-Avi, N-His labeled tag. NKG2C-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 25-35 kDa.
  • HY-P700798
    NKG2C-CD94 Heterodimer Protein, Cynomolgus (HEK293, His-Flag)

    NKG2C&CD94; NKG2C; CD94

    		Cynomolgus HEK293
    The NKG2C/CD159c protein is an immune-activating receptor that plays a critical role in self-non-self discrimination. It cooperates with KLRD1 to recognize non-classical MHC class Ib HLA-E loaded with HLA-G peptides, affecting adaptive NK cell function and maternal-fetal tolerance. NKG2C-CD94 Heterodimer Protein, Cynomolgus (HEK293, His-Flag) is a recombinant protein dimer complex containing cynomolgus-derived NKG2C-CD94 Heterodimer protein, expressed by HEK293 , with N-His, C-Flag labeled tag. NKG2C-CD94 Heterodimer Protein, Cynomolgus (HEK293, His-Flag), has molecular weight of 35-45 kDa.
Cat. No. Product Name Effect Purity