AIM2-like receptors
Absent in melanoma 2 (AIM2)-like receptors (ALRs) are a family of pathogen recognition receptors (PRRs) involved in cytosolic and nuclear pathogen DNA recognition. Structurally, ALRs are characterized by a Pyrin signaling domain and a DNA-binding HIN domain. Interestingly, the ALR locus is highly variable in different species, For example, humans have 4 ALRs (AIM2, IFI16, PYHIN1, and MNDA), while mice have 13 or 14, including Aim2, p202, p203, p204, p205, p207, pyhin1, and cows have a single ALR. The best characterized ALR is AIM2 (absent in melanoma 2), the intracellular DNA sensor which signals via the adaptor protein ASC (Apoptosis-associated speck-like protein containing a CARD), to activate the inflammasome, a key arm of the innate immune system.
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AIM2-like receptors Recombinant Proteins (24)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
