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  3. Thyroid Hormone Receptor

Thyroid Hormone Receptor

The thyroid hormone receptor (THR) is a type of nuclear receptor which belongs to a superfamily of eukaryotic transcription factors. It regulates gene expression in response to binding small, hydrophobic ligands. The receptors exhibits a modular structure, with functionally separable domains. The most highly conserved domains are the DNA-binding domain (DBD) and the ligand-binding domain (LBD). The DBD recognizes the specific DNA responses element for the receptor. The LBD participates in several activities, including hormone binding, homo- and/or heterodimerization, formation of heat-shock-protein complex, and transcriptional activation and repression. Unliganded thyroid hormone receptors are bound to DNA thyroid hormone response elements predominantly as homodimers, or as heterodimers with retinoid X-receptors, and are associated with a complex of proteins containing corepressor proteins. Ligand binding promotes corepressor dissociation and binding of a coactivator. Hormone binding induces changes in receptor conformation that control these properties and influence gene expression.

Thyroid Hormone Receptor Related Products (23):

Cat. No. Product Name Effect Purity
  • HY-A0070A
    Liothyronine Activator 98.97%
    Liothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.
  • HY-A0070
    Liothyronine sodium Activator 99.17%
    Liothyronine sodium is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.
  • HY-12216
    Resmetirom Agonist 99.77%
    Resmetirom (MGL-3196) is a highly selective thyroid hormone receptor β (THR-β) agonist with an EC50 value of 0.21 μM.
  • HY-18341
    L-Thyroxine >98.0%
    L-Thyroxine (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
  • HY-14823
    Sobetirome Agonist 99.79%
    Sobetirome is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC50 of 0.16 μM.
  • HY-108742A
    Abaloparatide TFA Activator
    Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue selected to be a potent and selective activator of the PTHR1 signaling pathway. Abaloparatide TFA enhances Gs/cAMP signaling (EC50 of 0.3 nM) and β-arrestin recruitment (EC50 of 0.9 nM) in MC3T3-E1 osteoblast cells.
  • HY-130012
    CO23 Agonist
    CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier.
  • HY-101406
    Thyroxine sulfate >98.0%
    Thyroxine sulfate is a thyroid hormone metabolite.
  • HY-10473
    Eprotirome Agonist 99.77%
    Eprotirome is a liver-selective thyroid hormone receptor agonist.
  • HY-B1201
    Tiratricol 98.97%
    Tiratricol is a thyroid hormone analog with hepatic, has been used to suppress pituitary TSH secretion, with attenuation of extrapituitary thyromimetic effects.
  • HY-111443
    TR antagonist 1 Antagonist 99.64%
    TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively.
  • HY-P0002A
    Protirelin Acetate Activator 99.98%
    Protirelin Acetate is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.
  • HY-18341A
    L-Thyroxine sodium salt pentahydrate 99.38%
    L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
  • HY-B0596
    Taltirelin Agonist >98.0%
    Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release).
  • HY-19513
    MB-07344 Agonist
    MB-07344 is a thyroid hormone receptor (TR)-β agonist with a binding affinity Ki of 2.17 nM.
  • HY-P0002
    Protirelin Activator
    Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.
  • HY-100856
    PCO371 Agonist
    PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor.
  • HY-125879
    DS08210767 Antagonist
    DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM.
  • HY-126236
    3,5-Diiodothyropropionic acid Modulator 98.94%
    3,5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (TR), with Ka of 2.40 and 4.06 M-1 for TRα1 and TRβ1, respectively.
  • HY-114272A
    T4-ATA (S-isomer) 99.74%
    T4-ATA S-isomer is the S-isomer of T4-ATA, which is the active form of the thyroid hormone.
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