1. Others
    Metabolic Enzyme/Protease
  2. Thyroid Hormone Receptor
    Endogenous Metabolite
  3. Liothyronine

Liothyronine (Synonyms: Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3)

Cat. No.: HY-A0070A Purity: 99.28%
Handling Instructions

Liothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.

For research use only. We do not sell to patients.

Liothyronine Chemical Structure

Liothyronine Chemical Structure

CAS No. : 6893-02-3

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10 mM * 1  mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 144 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Liothyronine:

Top Publications Citing Use of Products

Publications Citing Use of MCE Liothyronine

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Liothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Liothyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. Liothyronine binds to human β1 thyroid hormone receptor (hTRβ1), and change its conformation. Liothyronine promotes growth, induces differentiation and regualtes metabolic effects[2].

Clinical Trial
Molecular Weight

650.97

Formula

C₁₅H₁₂I₃NO₄

CAS No.

6893-02-3

SMILES

OC1=C(I)C=C(OC2=C(I)C=C(C[[email protected]](N)C(O)=O)C=C2I)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (128.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5362 mL 7.6808 mL 15.3617 mL
5 mM 0.3072 mL 1.5362 mL 3.0723 mL
10 mM 0.1536 mL 0.7681 mL 1.5362 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.20 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.20 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.20 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

Thyroid hormone depleted (Td) serum is prepared. The growth of hepatocarcinoma cells in methylcellulose is performed. To determine the effect of Liothyronine (T3) on the growth of cells, cells are plated at a density of 3 × l04 cells/60 mm dish on day 0, and incubated in medium containing 5% regular serum, 5% Td or 5% Td and 100 nM T3. The colony formation in methylcellulose is scored 3 weeks after initial plating[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.28%

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Keywords:

LiothyronineTriiodothyronine3,3',5-Triiodo-L-thyronineT3T 3T-3Thyroid Hormone ReceptorEndogenous MetaboliteTHRInhibitorinhibitorinhibit

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Liothyronine
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HY-A0070A
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