1. Others
    Metabolic Enzyme/Protease
  2. Thyroid Hormone Receptor
    Endogenous Metabolite
  3. Liothyronine

Liothyronine  (Synonyms: Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3)

Cat. No.: HY-A0070A Purity: 99.82%
COA Handling Instructions

Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.

For research use only. We do not sell to patients.

Liothyronine Chemical Structure

Liothyronine Chemical Structure

CAS No. : 6893-02-3

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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Liothyronine:

Top Publications Citing Use of Products
  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Liothyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. Liothyronine binds to human β1 thyroid hormone receptor (hTRβ1), and changes its conformation. Liothyronine promotes growth, induces differentiation and regualtes metabolic effects[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

650.97

Formula

C15H12I3NO4

CAS No.
SMILES

OC1=C(I)C=C(OC2=C(I)C=C(C[[email protected]](N)C(O)=O)C=C2I)C=C1

Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

1M NaOH : 50 mg/mL (76.81 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5362 mL 7.6808 mL 15.3617 mL
5 mM 0.3072 mL 1.5362 mL 3.0723 mL
10 mM 0.1536 mL 0.7681 mL 1.5362 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.82%

References
Cell Assay
[1]

Thyroid hormone depleted (Td) serum is prepared. The growth of hepatocarcinoma cells in methylcellulose is performed. To determine the effect of Liothyronine (T3) on the growth of cells, cells are plated at a density of 3 × l04 cells/60 mm dish on day 0, and incubated in medium containing 5% regular serum, 5% Td or 5% Td and 100 nM T3. The colony formation in methylcellulose is scored 3 weeks after initial plating[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Liothyronine
Cat. No.:
HY-A0070A
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