1. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  2. Thyroid Hormone Receptor Endogenous Metabolite
  3. Liothyronine

Liothyronine  (Synonyms: Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3)

Cat. No.: HY-A0070A Purity: 99.82%
COA Handling Instructions

Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.

For research use only. We do not sell to patients.

Liothyronine Chemical Structure

Liothyronine Chemical Structure

CAS No. : 6893-02-3

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Customer Review

Based on 12 publication(s) in Google Scholar

Other Forms of Liothyronine:

Top Publications Citing Use of Products
  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

hepatocarcinomaLiothyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. Liothyronine binds to the human β1 thyroid hormone receptor (hTRβ1), and changes its conformation. Liothyronine promotes growth, induces differentiation and regualtes metabolic effects[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

650.97

Formula

C15H12I3NO4

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(I)C=C(OC2=C(I)C=C(C[C@H](N)C(O)=O)C=C2I)C=C1

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (76.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

1M NaOH : 50 mg/mL (76.81 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5362 mL 7.6808 mL 15.3617 mL
5 mM 0.3072 mL 1.5362 mL 3.0723 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.82%

References
Cell Assay
[1]

Thyroid hormone depleted (Td) serum is prepared. The growth of hepatocarcinoma cells in methylcellulose is performed. To determine the effect of Liothyronine (T3) on the growth of cells, cells are plated at a density of 3 × l04 cells/60 mm dish on day 0, and incubated in medium containing 5% regular serum, 5% Td or 5% Td and 100 nM T3. The colony formation in methylcellulose is scored 3 weeks after initial plating[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / 1M NaOH 1 mM 1.5362 mL 7.6808 mL 15.3617 mL 38.4042 mL
5 mM 0.3072 mL 1.5362 mL 3.0723 mL 7.6808 mL
10 mM 0.1536 mL 0.7681 mL 1.5362 mL 3.8404 mL
15 mM 0.1024 mL 0.5121 mL 1.0241 mL 2.5603 mL
20 mM 0.0768 mL 0.3840 mL 0.7681 mL 1.9202 mL
25 mM 0.0614 mL 0.3072 mL 0.6145 mL 1.5362 mL
30 mM 0.0512 mL 0.2560 mL 0.5121 mL 1.2801 mL
40 mM 0.0384 mL 0.1920 mL 0.3840 mL 0.9601 mL
50 mM 0.0307 mL 0.1536 mL 0.3072 mL 0.7681 mL
60 mM 0.0256 mL 0.1280 mL 0.2560 mL 0.6401 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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