1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. DNA/RNA Synthesis
    Endogenous Metabolite
  3. Adenine

Adenine (Synonyms: 6-Aminopurine; Vitamin B4)

Cat. No.: HY-B0152 Purity: 98.76%
Handling Instructions

Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry.

For research use only. We do not sell to patients.

Adenine Chemical Structure

Adenine Chemical Structure

CAS No. : 73-24-5

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10 mM * 1 mL in DMSO USD 55 In-stock
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Description

Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry. Target: Nucleoside antimetabolite/analog Adenine is a nucleobase with a variety of roles in biochemistry including cellular respiration, in the form of both the energy-rich adenosine triphosphate (ATP) and the cofactors nicotinamide adenine dinucleotide (NAD) and flavin adenine dinucleotide (FAD), andprotein synthesis, as a chemical component of DNA and RNA. The shape of adenine is complementary to either thymine in DNA or uracil in RNA. In older literature, adenine was sometimes called Vitamin B4. It is no longer considered a true vitamin or part of the Vitamin B complex. However, two B vitamins, niacin and riboflavin, bind with adenine to form the essential cofactors nicotinamide adenine dinucleotide (NAD) and flavin adenine dinucleotide (FAD), respectively. Hermann Emil Fischer was one of the early scientists to study adenine. Experiments performed in 1961 by Joan Oró have shown that a large quantity of adenine can be synthesized from the polymerization of ammonia with fivehydrogen cyanide (HCN) molecules in aqueous solution, whether this has implications for the origin of life on Earth is under debate.

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

135.13

Formula

C₅H₅N₅

CAS No.

73-24-5

SMILES

NC1=C2N=CNC2=NC=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (148.01 mM; Need ultrasonic)

1M HCl : 20 mg/mL (148.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.4003 mL 37.0014 mL 74.0028 mL
5 mM 1.4801 mL 7.4003 mL 14.8006 mL
10 mM 0.7400 mL 3.7001 mL 7.4003 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Adenine6-AminopurineVitamin B4Vitamin B 4Vitamin B-4DNA/RNA SynthesisEndogenous MetaboliteInhibitorinhibitorinhibit

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