2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Endogenous Metabolite DNA/RNA Synthesis
  4. Adenine monohydrochloride hemihydrate

Adenine monohydrochloride hemihydrate 

Cat. No.: HY-W015213 Purity: 99.87%
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Adenine monohydrochloride hemihydrate is a hydrochloride derivative of Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.

For research use only. We do not sell to patients.

CAS No. : 6055-72-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Based on 22 publication(s) in Google Scholar

Other Forms of Adenine monohydrochloride hemihydrate:

Adenine monohydrochloride hemihydrate Related Antibodies

Top Publications Citing Use of Products

    Adenine monohydrochloride hemihydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067.  [Abstract]

    Capsaicin (10 and 15mg/kg, i.p.,once per week for 8 weeks) treatment lessened the deposition of ECM proteins in the kidneys from Adenine (0.25% w/w)-fed mice. Representative images of MTS (blue color), Picrosirius Red staining (red color), and IF staining of fibronectin (red color) and COL1A1 (green color) for kidney sections from adenine-fed (Adenine) or normal-fed (Ctrl) mice. Scale bars are 50 μm.

    Adenine monohydrochloride hemihydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067.  [Abstract]

    Capsaicin (10 and 15 mg/kg, i.p., once per week for 8 weeks) treatment lessened the deposition of ECM proteins in the kidneys from Adenine (0.25% w/w)-fed mice. WB images of fibronectin and COL1A1 expressions in kidney lysates from mice.

    Adenine monohydrochloride hemihydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067.  [Abstract]

    Capsaicin(10 or 15 mg/kg, i.p., once per week for 8 weeks) improved survival rate of Adenine (0.25% w/w)-fed mice. (A) Relative weight curves of indicated mice as described in A (n = 6). Mouse weight is measured once per 3 days, the initial weight is set to 1, and day 0 means the time point starting Adenine-rich diet. (B) Kaplan-Meier survival analysis of indicated mice as described in A (n = 12). Data are means ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.

    Adenine monohydrochloride hemihydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067.  [Abstract]

    Capsaicin(10 or 15 mg/kg, i.p., once per week for 8 weeks) improved kidney function of Adenine (0.25% w/w)-fed mice. Concentrations of serum creatinine, urea, and albumin from mice (n = 8). Data are means ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.

    Adenine monohydrochloride hemihydrate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Mar 21;100:154067.  [Abstract]

    Capsaicin(10 or 15 mg/kg, i.p., once per week for 8 weeks) treatment prevented phenotypic alteration of tubular epithelial cells in the kidneys from Adenine (ADE) (0.25% w/w)-fed mice. Representative IHC staining images of E-cadherin and vimentin kidney sections from mice. Scale bars are 25 μm.

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    Description

    Adenine monohydrochloride hemihydrate is a hydrochloride derivative of Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].

    Molecular Weight

    189.60

    Formula

    C5H8ClN5O
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    NC(N=CN1)=C2C1=NC=N2.Cl.O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 8.33 mg/mL (43.93 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.2743 mL 26.3713 mL 52.7426 mL
    5 mM 1.0549 mL 5.2743 mL 10.5485 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Working solution concentration: mg/mL
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 5.2743 mL 26.3713 mL 52.7426 mL 131.8565 mL
    5 mM 1.0549 mL 5.2743 mL 10.5485 mL 26.3713 mL
    10 mM 0.5274 mL 2.6371 mL 5.2743 mL 13.1857 mL
    15 mM 0.3516 mL 1.7581 mL 3.5162 mL 8.7904 mL
    20 mM 0.2637 mL 1.3186 mL 2.6371 mL 6.5928 mL
    25 mM 0.2110 mL 1.0549 mL 2.1097 mL 5.2743 mL
    30 mM 0.1758 mL 0.8790 mL 1.7581 mL 4.3952 mL
    40 mM 0.1319 mL 0.6593 mL 1.3186 mL 3.2964 mL
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    Adenine monohydrochloride hemihydrate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Adenine monohydrochloride hemihydrate6055-72-7Endogenous MetaboliteDNA/RNA SynthesisAdenineInhibitorinhibitorinhibit

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