Protein Crystal Structure Elucidation

Protein crystal structure analysis is one of the most important technologies in modern biology, which can use the 3D structure of biological macromolecules to infer their functions. The main technical means for studying the 3D structure of biological macromolecules is X-ray crystal diffraction.

The diffraction pattern is obtained by irradiating protein crystals with X-rays, and then the diffraction pattern is analyzed to infer the atomic arrangement of the protein. With the rapid development of structural biology, protein crystallography has been extended from merely elucidating the 3D structures of proteins to elucidating the structures of various protein complexes.

Applicable fields of protein crystal structure analysis:

• X-ray crystal diffraction technology can be used to analyze the structure of protein-compound complexes to construct an interaction network between
compounds and targets, thereby elucidating the mechanism of action, optimizing the compound structure, etc.
• By analyzing the structure of the antigen-antibody complexes, we can identify the antigen epitope and provide the basis for antibody modification;
• Protein crystal structure analysis is an important tool for new drug development and is widely used in structure-based drug design.

MedChemExpress has a professional protein crystal structure analysis platform and a mature protein expression and purification technology service platform, which can provide one-stop services from protein expression to structure analysis for your research!

Process

Protein Expression
and Purification Crystal X-ray Diffracion
and Data Collection Structure Elucidation Structure Analysis

Figure 1. Process for protein structure determination using X-ray crystallography.

Advantages

One-stop service
from protein
expression to
structure elucidation
Proven protein
expression
purification system
Professional
protein crystal
structure research
platform
Experienced technical
service team
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price advantage
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