1. Recombinant Proteins
  2. Enzymes & Regulators
  3. Protein Tyrosine Kinases

Protein Tyrosine Kinases

Tyrosine kinases are a family of enzymes, which catalyzes phosphorylation of select tyrosine residues in target proteins by using ATP as phosphate donor. Tyrosine kinases are primarily divided into receptor tyrosine kinase (RTK) such as EGFR, PDGFR, FGFR and the IR, and non-receptor tyrosine kinase (NRTK) such as SRC, ABL, FAK and Janus kinase. Of the 90 tyrosine kinases in human, 58 are receptor type, distributed into 20 classes. The 32 NRTKs can be placed in 10 classes. Tyrosine kinases are important mediators of the signaling cascade, determining key roles in diverse biological processes like growth, differentiation, adhesion, motility, metabolism and apoptosis in response to external and internal stimuli. In humans, it is reported that tyrosine kinases play significant roles in the development of many disease states, including diabetes and cancer. In addition, tyrosine kinase genes have also been linked to a wide variety of congenital syndromes.

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