1. Recombinant Proteins
  2. Receptor Proteins
  3. Enzyme-linked receptors
  4. DDR family

Discoidin domain receptor tyrosine kinases (DDRs), a subfamily of the receptor tyrosine kinases (RTKs), recognize collagens as their ligands. They represent the only RTKs that are directly activated upon contact of cells with their collagenous matrix. Collagen binding to DDRs stimulates DDR phosphorylation activating kinase activity, signaling to MAPK, integrin, TGF-β, insulin receptor, and Notch signaling pathways. DDR family comprises two distinct members, DDR1 and DDR2. DDRs are widely expressed, with predominant expression of DDR1 in epithelial cells and DDR2 in mesenchymal cells. Structurally, DDRs consist of three regions (an extracellular ligand binding domain, a transmembrane domain, and an intracellular region containing a kinase domain), with their kinase activity induced by receptor-specific ligand binding. DDRs bind a number of different collagen types and play important roles in embryo development. Dysregulation of DDRs is associated with progression of multiple diseases, including fibrosis, chronic inflammatory conditions, and cancer. Thus, DDRs are promising therapeutic molecular targets.

Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name Effect Purity