DDR1 Protein, Rat (HEK293, hFc)
The DDR1 protein is a fibrillar collagen receptor that coordinates key cellular processes including matrix remodeling, migration, differentiation, survival, and proliferation.Upon collagen binding, DDR1 activates signaling cascades involving SRC and MAP kinases, promoting matrix remodeling through MMP upregulation, promoting cell migration, wound healing, and tumor invasion.DDR1 Protein, Rat (HEK293, hFc) is the recombinant rat-derived DDR1 protein, expressed by HEK293 , with C-hFc labeled tag.
- Species: Rat
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
The DDR1 protein is a fibrillar collagen receptor that coordinates key cellular processes including matrix remodeling, migration, differentiation, survival, and proliferation.Upon collagen binding, DDR1 activates signaling cascades involving SRC and MAP kinases, promoting matrix remodeling through MMP upregulation, promoting cell migration, wound healing, and tumor invasion.DDR1 Protein, Rat (HEK293, hFc) is the recombinant rat-derived DDR1 protein, expressed by HEK293 , with C-hFc labeled tag.
DDR1 protein, a tyrosine kinase functioning as a cell surface receptor for fibrillar collagen, orchestrates diverse cellular processes critical for tissue homeostasis. It regulates cell attachment to the extracellular matrix, influencing matrix remodeling, cell migration, differentiation, survival, and proliferation. Upon collagen binding, DDR1 initiates a signaling cascade involving SRC and leading to MAP kinase activation. This intricate network contributes to extracellular matrix remodeling through the up-regulation of matrix metalloproteinases MMP2, MMP7, and MMP9, facilitating cell migration and wound healing, as well as promoting tumor cell invasion. DDR1's impact extends to arterial wound healing by promoting smooth muscle cell migration. Furthermore, it phosphorylates PTPN11 and is indispensable for normal blastocyst implantation during pregnancy, mammary gland differentiation, lactation, and maintenance of normal ear morphology and hearing. The multifunctional role of DDR1 underscores its significance in governing diverse physiological processes.
This product does not contain protein kinase domain.
Technical Parameters
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Species Rat
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Source HEK293
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Tag C-hFc
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Accession
Q6MG19 (D20-T413)
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Molecular Construction
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N-term
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DDR1 (D20-T413)
Accession # Q6MG19 -
hFc
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C-term
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Protein Length
Partial
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Synonyms
Epithelial discoidin domain-containing receptor 1; HGK2; CD167a; CAK; EDDR1
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AA Sequence
DADMKGHFDPAKCRYALGMQDRTIPDSDISVSSSWSDSTAARHSRLESSDGDGAWCPAGPVFPKEEEYLQVDLRRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRWMDWKDRWGQEVISGNEDPGGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMQLSEMVYLNDSTYDGYTAGGLQYGGLGQLADGVVGLDDFRQSQELRVWPGYDYVGWSNHSFPSGYVEMEFEFDRLRSFQTMQVHCNNMHTLGARLPGGVECRFKRGPAMAWEGEPVRHALGGSLGDPRARAISVPLGGHVGRFLQCRFLFAGPWLLFSEISFISDVVNDSSDTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPT
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Predicted Molecular Mass
70.9 kDa
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Molecular Weight
Approximately 71 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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