1. Cell Cycle/DNA Damage
  2. Topoisomerase

Topoisomerase

Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. Topoisomerases are isomerase enzymes that act on the topology of DNA. Type I topoisomerase cuts one strand of a DNA double helix, relaxation occurs, and then the cut strand is reannealed. Type I topoisomerases are subdivided into two subclasses: type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases, and type IB topoisomerases, which utilize a controlled rotary mechanism. Type II topoisomerase cuts both strands of one DNA double helix, pass another unbroken DNA helix through it, and then reanneal the cut strands. This class is also split into two subclasses: type IIA and type IIB topoisomerases, which possess similar structure and mechanisms.

Topoisomerase Isoform Specific Products:

  • Topoisomerase

  • Topo I

  • Topo II

Topoisomerase Related Products (54):

Cat. No. Product Name Effect Purity
  • HY-15142
    Doxorubicin hydrochloride Inhibitor 99.47%
    Doxorubicin hydrochloride is a cytotoxic anthracycline antibiotic for the treatment of multiple cancers. The possible mechanisms by which doxorubicin acts in the cancer cell are intercalation into DNA and disruption of topoisomerase-II-mediated DNA repair.
  • HY-13629
    Etoposide Inhibitor 99.65%
    Etoposide is a chemotherapy medication used for the treatments of a number of types of cancer. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.
  • HY-16560
    Campathecin Inhibitor 98.26%
    Campathecin is a potent DNA enzyme topoisomerase I inhibitor, with an IC50 of 679 nM.
  • HY-13624A
    Epirubicin hydrochloride Inhibitor 98.15%
    Epirubicin (hydrochloride) is a semisynthetic L-arabino derivative of doxorubicin, and an antineoplastic agent by inhibiting Topoisomerase.
  • HY-16562
    Irinotecan Inhibitor 99.84%
    Irinotecan is a water soluble topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex.
  • HY-18351
    Indotecan Inhibitor
    Indotecan (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively.
  • HY-13704
    Camptothecin 11 Inhibitor 99.46%
    SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively.
  • HY-13768A
    Topotecan Hydrochloride Inhibitor 99.20%
    Topotecan hydrochloride is a Topoisomerase I inhibitor with potent antineoplastic activities.
  • HY-16562A
    Irinotecan hydrochloride Inhibitor 99.75%
    Irinotecan hydrochloride is a water soluble topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer.
  • HY-13062
    Daunorubicin Hydrochloride Inhibitor 99.27%
    Daunorubicin hydrochloride is a topoisomerase II inhibitor with potent antineoplastic activities.
  • HY-13631A
    Exatecan Mesylate Inhibitor 98.09%
    Exatecan Mesylate is a water soluble topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.
  • HY-13061
    Daun02 Inhibitor 98.56%
    Daun02 is a prodrug of the topoisomerase inhibitor Daunorubicin.
  • HY-13502
    Mitoxantrone Inhibitor >98.0%
    Mitoxantrone is a topoisomerase II inhibitor; also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM.
  • HY-17381
    Idarubicin hydrochloride Inhibitor 99.62%
    Idarubicin hydrochloride is an anthracycline antileukemic drug. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription.
  • HY-16568
    Irinotecan hydrochloride trihydrate Inhibitor 99.59%
    Irinotecan hydrochloride trihydrate is a water soluble topoisomerase I inhibitor with antitumor activity.
  • HY-13555
    β-Lapachone Inhibitor 99.72%
    β-Lapachone is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.
  • HY-13761
    Teniposide Inhibitor 99.84%
    Teniposide is a podophyllotoxin derivative, acts as a topoisomerase II inhibitor, and used as a chemotherapeutic agent.
  • HY-13551
    Amsacrine Inhibitor 99.98%
    Amsacrine is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells.
  • HY-10529
    Betulinic acid Inhibitor 98.58%
    Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties.
  • HY-13502A
    Mitoxantrone dihydrochloride Inhibitor
    Mitoxantrone dihydrochloride is a topoisomerase II inhibitor; also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM.
Isoform Specific Products

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