2. Cell Cycle/DNA Damage
    Anti-infection
  3. Topoisomerase
    DNA/RNA Synthesis
    Antibiotic
    Bacterial
    Orthopoxvirus
  4. Levofloxacin

Levofloxacin  (Synonyms: (-)-Ofloxacin)

Cat. No.: HY-B0330 Purity: 99.93%
COA Handling Instructions

Levofloxacin ((-)-Ofloxacin) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin inhibits the DNA gyrase and topoisomerase IV. Levofloxacin can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin shows anti-orthopoxvirus activity.

For research use only. We do not sell to patients.

Levofloxacin Chemical Structure

Levofloxacin Chemical Structure

CAS No. : 100986-85-4

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Solution
10 mM * 1 mL in DMSO USD 73 In-stock
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10 mM * 1 mL
ready for reconstitution
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Solid
100 mg USD 66 In-stock
5 g USD 92 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Levofloxacin:

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Topoisomerase Topo I Topo II

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Levofloxacin ((-)-Ofloxacin) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin inhibits the DNA gyrase and topoisomerase IV. Levofloxacin can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin shows anti-orthopoxvirus activity[1][2][3][4][5].

IC50 & Target

Quinolone

 

TOPO IV

 

In Vitro

Levofloxacin shows inhibition effects to M. tuberculosis susceptible strains OFLO, LVFX, and SPFX with MIC50 values of 1.0, 0.5 and 0.25 μg/mL, respectively[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Levofloxacin (10.7 mg/kg; i.p., once daily for 10 days or 3 weeks) time-dependently induces toxic effects on liver and heart in albino mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Matured male Albino mice[3]
Dosage: 10.7 mg/kg
Administration: Intraperitoneal injection; 10.7 mg/kg, once daily for 10 days or 3 weeks.
Result: Induced severe congestion of blood vessels in the portal area, central veins with inflammatory cells infiltration, necrosis with pyknosis of cardiac muscle nuclei and apoptosis, degeneration and necrosis of hepatocytes.
Clinical Trial
Molecular Weight

361.37

Appearance

Solid

Formula

C18H20FN3O4
CAS No.
SMILES

O=C(C(C1=O)=CN2[[email protected]@H](C)COC3=C(N4CCN(C)CC4)C(F)=CC1=C23)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (27.67 mM; Need ultrasonic)

H2O : ≥ 5 mg/mL (13.84 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7672 mL 13.8362 mL 27.6725 mL
5 mM 0.5534 mL 2.7672 mL 5.5345 mL
10 mM 0.2767 mL 1.3836 mL 2.7672 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL (27.67 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (2.77 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (2.77 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (2.77 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.93%

COA (249 KB) HNMR (276 KB) LCMS (266 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Levofloxacin100986-85-4(-)-OfloxacinTopoisomeraseDNA/RNA SynthesisAntibioticBacterialOrthopoxviruschronic periodontitisairway inflammationBK ViremiaDNA gyraseInhibitorinhibitorinhibit

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