1. Anti-infection
  2. Bacterial
  3. Levofloxacin (hydrate)

Levofloxacin (hydrate) (Synonyms: Levofloxacin hemihydrate)

Cat. No.: HY-B0330A Purity: 99.39%
Handling Instructions

Levofloxacin hydrate is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

For research use only. We do not sell to patients.

Levofloxacin (hydrate) Chemical Structure

Levofloxacin (hydrate) Chemical Structure

CAS No. : 138199-71-0

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 g USD 84 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Levofloxacin (hydrate):

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Description

Levofloxacin hydrate is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. Target: Antibacterial Levofloxacin reduced bacterial load compared with placebo by 4.9-fold (95% confidence interval, 1.4-25.7; P=0.02) at day 7 but had no effect at any point on any marker of neutrophilic airway inflammation. In patients with a baseline bacterial load of more than 10(6) cfu/mL, levofloxacin treatment was associated with a 26.5% (95% confidence interval, 1.8%-51.3%; P=0.04) greater reduction in the percentage neutrophil count compared with placebo at day 7 [1]. Levofloxacin was found to significantly improve the clinical and microbiological parameters in CP individuals [2]. A 30-day course of levofloxacin does not significantly improve BK viral load reduction or allograft function when used in addition to overall reduction of immunosuppression [3].

Clinical Trial
Molecular Weight

370.38

Formula

C₁₈H₂₀FN₃O₄ . ₀.₅H₂O

CAS No.

138199-71-0

SMILES

O=C(C(C1=O)=CN2[[email protected]@H](C)COC3=C(N4CCN(C)CC4)C(F)=CC1=C23)O.[0.5H2O]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (135.00 mM)

DMSO : 8.33 mg/mL (22.49 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6999 mL 13.4996 mL 26.9993 mL
5 mM 0.5400 mL 2.6999 mL 5.3999 mL
10 mM 0.2700 mL 1.3500 mL 2.6999 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (2.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.83 mg/mL (2.24 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.83 mg/mL (2.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.39%

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Keywords:

Levofloxacin (hydrate)Levofloxacin hemihydrateBacterialInhibitorinhibitorinhibit

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Levofloxacin (hydrate)
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