Levofloxacin hydrochloride
Based on 41 publication(s) in Google Scholar
Levofloxacin hydrochloride ((-)-Ofloxacin hydrochloride) is an orally active broad-spectrum antibacterial agent with antioxidant and antibacterial activities. Levofloxacin hydrochloride upregulates TC synthesis-related genes and transport-related genes, reduces plasma PCSK9, inhibits GABAA receptors and mitochondrial complexes I/III, scavenges hydroxyl radicals and neutrophil-derived ROS, and inhibits NO metabolites and interferon-γ. Levofloxacin hydrochloride improves survival, alleviates lung injury, and reduces oxidative and inflammatory markers in influenza virus-infected mice. Levofloxacin hydrochloride inhibits lung cancer proliferation and xenograft tumor growth, and induces apoptosis and oxidative stress. Levofloxacin hydrochloride can be used in research on bacterial infection, influenza virus infection, atherosclerosis, and lung cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.99%
- CAS. Nr.: 177325-13-2
- Formel: C18H21ClFN3O4
- Molecular Weight:397.83
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Publications Citing Use of MedChemExpress (MCE) Levofloxacin hydrochloride
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Nat Commun. 2025 May 10;16(1):4366. [Abstract]
- Nat Commun. 2022 Mar 2;13(1):1116. [Abstract]
- Acta Pharm Sin B. 2025 Dec;15(12):6382-6398. [Abstract]
- Sci Adv. 2026 Jun 12;12(24):eaed2731. [Abstract]
- Chem Eng J. 2026 Feb 12.
- J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
- EBioMedicine. 2025 Jul:117:105776. [Abstract]
- Food Res Int. 2026 Aug 31:238:119421. [Abstract]
- Clin Chem. 2019 Dec;65(12):1522-1531. [Abstract]
- Emerg Microbes Infect. 2024 Dec;13(1):2321981. [Abstract]
- Virulence. 2026 Dec 31;17(1):2646808. [Abstract]
- Commun Biol. 2025 Oct 6;8(1):1425. [Abstract]
- Results Chem. 2024 Oct.
- Cell Rep Methods. 2023 Oct 23;3(10):100599. [Abstract]
- Antibiotics (Basel). 2022 Feb 1;11(2):192. [Abstract]
- Int J Antimicrob Agents. 2025 Oct;66(4):107551. [Abstract]
- PLoS Pathog. 2026 Jan 26;22(1):e1013903. [Abstract]
- Toxics. 2025 Feb 5;13(2):122. [Abstract]
- iScience. 2026 Aug 28;29(9):117291.
- ACS Infect Dis. 2024 Apr 12;10(4):1327-1338. [Abstract]
- Antimicrob Agents Chemother. 2021 Feb 17;65(3):e01921-20. [Abstract]
- Microbiol Spectr. 2025 Oct 15:e0122125. [Abstract]
- Microbiol Spectr. 2025 Jul;13(7):e0307424. [Abstract]
- AMB Express. 2024 Dec 24;14(1):141. [Abstract]
- J Med Virol. 2025 Oct;97(10):e70655. [Abstract]
- Water. 2025 Jun 6.
- Infect Drug Resist. 2026 May 8;19.
- Eur J Clin Microbiol Infect Dis. 2025 Sep 29. [Abstract]
- PLoS One. 2026 Jul 8;21(7):e0352997.
- Infect Genet Evol. 2025 Sep:133:105780. [Abstract]
- PLoS One. 2024 Apr 18;19(4):e0298577. [Abstract]
- Future Microbiol. 2025 Oct 13:1-10. [Abstract]
- Chin J Traumatol. 2024 Sep;27(5):295-304. [Abstract]
- Diagn Microbiol Infect Dis. 2026 Nov;116(3):117584.
- Diagn Microbiol Infect Dis. 2026 Feb;114(2):117181. [Abstract]
- Res Sq. 2026 Mar 9.
- SSRN. 2025 Oct 14.
- Res Sq. 2025 Aug 05.
- bioRxiv. 2025 January 19.
- bioRxiv. 2024 May 10.
Customer Validation & Images
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Microbiological Assay
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Microbiological Assay
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Cell Proliferation/Viability Assay
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Microbiological Assay
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Microbiological Assay
Alle Topoisomerase Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
Beschreibung
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Research Protocol for Infectious Diseases
- Annexin V plus membrane-impermeant dye apoptosis staining
- ROS/oxidative-stress fluorescent staining
- Patient-Derived Orthotopic Xenograft (PDOX)
- Research Protocol for Cardiovascular Diseases
- Cell Viability Determination by MTT Colorimetric Assay
- Phagocytosis Functional Assay
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Patient-Derived Xenograft (PDX)
- Apoptosis Solutions
- Splenic/Portal-Vein Liver Metastasis Xenograft
- Inhalation Toxicity Study
- Subcutaneous Cell-Line-Derived Xenograft
- Orthotopic Cell-Line Xenograft
- Intraperitoneal/Peritoneal Dissemination Xenograft
Chemical Information
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CAS. Nr. 177325-13-2
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Appearance Solid
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Molecular Weight 397.83
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Formel C18H21ClFN3O4
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Color White to off-white
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SMILES
[H]Cl.O=C(C(C1=O)=CN2[C@@H](C)COC3=C(N4CCN(C)CC4)C(F)=CC1=C23)O
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Synonyms
(-)-Ofloxacin hydrochloride
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (41)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Nat Commun
Phenotypic drug susceptibility testing for Mycobacterium tuberculosis variant bovis BCG in 12 hours. [Abstract]2025 May 10;16(1):4366. PMID: 40348759
Levofloxacin hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 May 10;16(1):4366. [Abstract]
M. bovis BCG Russia WT in LFX (0-25 h) 1 mg/L.
Levofloxacin hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 May 10;16(1):4366. [Abstract]
M. bovisBCG Russia FQR in LFX (0-25 h) 1 mg/L.
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Nat Commun
Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China. [Abstract]2022 Mar 2;13(1):1116. PMID: 35236849 -
Acta Pharm Sin B
2025 Dec;15(12):6382-6398. PMID: 41477334
Levofloxacin hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Dec;15(12):6382-6398. [Abstract]
Levofloxacin exhibited toxicity at 25 × Cmax, which resulted in a 65% reduction in organoid cell viability.
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Sci Adv
Quantitative prediction of siRNA complexation by ionizable drugs enables their codelivery in nanoparticles. [Abstract]2026 Jun 12;12(24):eaed2731. PMID: 42284421 -
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J Exp Med
2026 Mar 2;223(3):e20241287. PMID: 41400657 -
EBioMedicine
Diverse impacts of different rpoB mutations on the anti-tuberculosis efficacy of capreomycin. [Abstract]2025 Jul:117:105776. PMID: 40449326
Levofloxacin hydrochloride purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2025 Jul:117:105776. [Abstract]
Killing curves of different Ms rpoB mutants after exposure to LFX (0-48 h) at 1 μg/mL (5 × MIC) in 7H9 medium.
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Food Res Int
Prevalence, plasmid transmission, and chromosomal integration of blaCTX-M genes in Salmonella isolated from retail chicken and pork meats in China. [Abstract]2026 Aug 31:238:119421. PMID: 42215089 -
Clin Chem
Discovering Cross-Reactivity in Urine Drug Screening Immunoassays through Large-Scale Analysis of Electronic Health Records. [Abstract]2019 Dec;65(12):1522-1531. PMID: 31578215 -
Emerg Microbes Infect
AMXT-1501 targets membrane phospholipids against Gram-positive and -negative multidrug-resistant bacteria. [Abstract]2024 Dec;13(1):2321981. PMID: 38422452 -
Virulence
Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]2026 Dec 31;17(1):2646808. PMID: 41838520 -
Commun Biol
The acetyltransferase CysE modulates virulence and drug resistance of Mycobacterium tuberculosis by interfering with oxidative stress responses. [Abstract]2025 Oct 6;8(1):1425. PMID: 41053365 -
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Cell Rep Methods
RECOVER identifies synergistic drug combinations in vitro through sequential model optimization. [Abstract]2023 Oct 23;3(10):100599. PMID: 37797618 -
Antibiotics (Basel)
Antibacterial Activity of the Novel Drug Gepotidacin against Stenotrophomonas maltophilia-An In Vitro and In Vivo Study. [Abstract]2022 Feb 1;11(2):192. PMID: 35203795
Levofloxacin hydrochloride purchased from MedChemExpress. Usage Cited in: Antibiotics (Basel). 2022 Feb 1;11(2):192. [Abstract]
Determined minimum inhibitory concentrations (MICs) of Gepotidacin, Levofloxacin, Moxifloxacin, and Co-trimoxazole against S. maltophilia.
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Int J Antimicrob Agents
Elucidating adaptive compensatory tigecycline resistance mechanisms of RamA, RarA and SoxS in Klebsiella pneumoniae. [Abstract]2025 Oct;66(4):107551. PMID: 40499596 -
PLoS Pathog
Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase. [Abstract]2026 Jan 26;22(1):e1013903. PMID: 41587213 -
Toxics
2025 Feb 5;13(2):122. PMID: 39997937 -
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ACS Infect Dis
Lusutrombopag as a Repurposing Drug in Combination with Aminoglycosides against Vancomycin-Resistant Enterococcus. [Abstract]2024 Apr 12;10(4):1327-1338. PMID: 38567846 -
Antimicrob Agents Chemother
Dihydrotanshinone I Is Effective against Drug-Resistant Helicobacter pylori In Vitro and In Vivo. [Abstract]2021 Feb 17;65(3):e01921-20. PMID: 33318002 -
Microbiol Spectr
Montelukast treats Streptococcus pneumoniae-induced sepsis via antibacterial and anti-inflammatory activities. [Abstract]2025 Oct 15:e0122125. PMID: 41090944 -
Microbiol Spectr
Antimicrobial resistance of rapidly growing mycobacteria isolated from companion animals in Taiwan. [Abstract]2025 Jul;13(7):e0307424. PMID: 40387379 -
AMB Express
Repurposing pinaverium bromide against Staphylococcus and its biofilms with new mechanisms. [Abstract]2024 Dec 24;14(1):141. PMID: 39718732 -
J Med Virol
Drug Repurposing: In Vitro Evaluation of Simeprevir as a Novel Antiviral Drug Against Severe Fever With Thrombocytopenia Syndrome Virus. [Abstract]2025 Oct;97(10):e70655. PMID: 41117261 -
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Eur J Clin Microbiol Infect Dis
Evaluation of EUCAST rapid antimicrobial susceptibility testing (RAST) for carbapenemase-producing Klebsiella pneumoniae with focus on KPC variants. [Abstract]2025 Sep 29. PMID: 41023358 -
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Infect Genet Evol
Polymyxin B combined with amikacin delays the resistance of Klebsiella pneumoniae to polymyxin B by modulating the expression of NlpE. [Abstract]2025 Sep:133:105780. PMID: 40480594 -
PLoS One
In vitro activity of ceftazidime/avibactam, cefiderocol, meropenem/vaborbactam and imipenem/relebactam against clinical strains of the Stenotrophomonas maltophilia complex. [Abstract]2024 Apr 18;19(4):e0298577. PMID: 38635685 -
Future Microbiol
2025 Oct 13:1-10. PMID: 41082411 -
Chin J Traumatol
The cytochrome P4501A1 (CYP1A1) inhibitor bergamottin enhances host tolerance to multidrug-resistant Vibrio vulnificus infection. [Abstract]2024 Sep;27(5):295-304. PMID: 38981821 -
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Diagn Microbiol Infect Dis
2026 Feb;114(2):117181. PMID: 41205476 -
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Lösungsmittel & Löslichkeit
In Vitro:
H2O : 50 mg/mL (125.68 mM; Need ultrasonic)
DMSO : 5.83 mg/mL (14.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Reinheit & Dokumentation
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Data Sheet (282 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[2]. Sheng Q H, et al. Levofloxacin Ameliorates Atherosclerosis By Regulating Lipid Metabolism. 2025.
[3]. Erden BF, et al. Antidepressant, anxiogenic, and antinociceptive properties of levofloxacin in rats and mice. Pharmacology, biochemistry, and behavior. 2001 Mar;68(3):435-41. [Content Brief]
[4]. Song M, et al. Antibiotic drug levofloxacin inhibits proliferation and induces apoptosis of lung cancer cells through inducing mitochondrial dysfunction and oxidative damage. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2016 Dec;84:1137-1143. [Content Brief]
[5]. JI B, et al. In vitro and in vivo activities of levofloxacin against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 1995 Jun;39(6):1341-4. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.5136 mL | 12.5682 mL | 25.1364 mL | 62.8409 mL |
| 5 mM | 0.5027 mL | 2.5136 mL | 5.0273 mL | 12.5682 mL | |
| 10 mM | 0.2514 mL | 1.2568 mL | 2.5136 mL | 6.2841 mL | |
| H2O | 15 mM | 0.1676 mL | 0.8379 mL | 1.6758 mL | 4.1894 mL |
| 20 mM | 0.1257 mL | 0.6284 mL | 1.2568 mL | 3.1420 mL | |
| 25 mM | 0.1005 mL | 0.5027 mL | 1.0055 mL | 2.5136 mL | |
| 30 mM | 0.0838 mL | 0.4189 mL | 0.8379 mL | 2.0947 mL | |
| 40 mM | 0.0628 mL | 0.3142 mL | 0.6284 mL | 1.5710 mL | |
| 50 mM | 0.0503 mL | 0.2514 mL | 0.5027 mL | 1.2568 mL | |
| 60 mM | 0.0419 mL | 0.2095 mL | 0.4189 mL | 1.0473 mL | |
| 80 mM | 0.0314 mL | 0.1571 mL | 0.3142 mL | 0.7855 mL | |
| 100 mM | 0.0251 mL | 0.1257 mL | 0.2514 mL | 0.6284 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Levofloxacin hydrochloride Related Classifications
HY-B0330B Related Classifications
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Keywords
- Levofloxacin
- 177325-13-2
- (-)-Ofloxacin
- Bacterial
- Orthopoxvirus
- Topoisomerase
- Reactive Oxygen Species (ROS)
- GABA Receptor
- PCSK9
- Apoptosis
- Gamma-aminobutyric acid Receptor
- γ-Aminobutyric acid Receptor
- Proprotein convertase subtilisin/kexin type 9
- GABA_A receptor
- LDLR
- antibacterial
- hepatic lipid regulator
- influenza virus
- lung cancer
- mitochondrial complex I
- mitochondrial complex III
- reactive oxygen species
- Inhibitor
- inhibitor
- inhibit