177325-13-2
177325-13-2
Chemical Structure
Levofloxacin hydrochloride
- No. CAS: 177325-13-2
- Formula:C18H21ClFN3O4
- Molecular Weight:397.83
IUPAC Name: (S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride
InChIKey: CAOOISJXWZMLBN-PPHPATTJSA-N
SMILES: [H]Cl.O=C(C(C1=O)=CN2[C@@H](C)COC3=C(N4CCN(C)CC4)C(F)=CC1=C23)O
Biological Activity: Levofloxacin hydrochloride is an orally active broad-spectrum antibacterial agent with antioxidant and antibacterial activities. Levofloxacin hydrochloride upregulates TC synthesis-related genes and transport-related genes, reduces plasma PCSK9, inhibits GABAA receptors and mitochondrial complexes I/III, scavenges hydroxyl radicals and neutrophil-derived ROS, and inhibits NO metabolites and interferon-γ. Levofloxacin hydrochloride improves survival, alleviates lung injury, and reduces oxidative and inflammatory markers in influenza virus-infected mice. Levofloxacin hydrochloride inhibits lung cancer proliferation and xenograft tumor growth, and induces apoptosis and oxidative stress. Levofloxacin hydrochloride can be used in research on bacterial infection, influenza virus infection, atherosclerosis, and lung cancer[1][2][3][4][5].
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Levofloxacin hydrochloride | 99.99% | Levofloxacin hydrochloride is an orally active broad-spectrum antibacterial agent with antioxidant and antibacterial activities. Levofloxacin hydrochloride upregulates TC synthesis-related genes and transport-related genes, reduces plasma PCSK9, inhibits GABAA receptors and mitochondrial complexes I/III, scavenges hydroxyl radicals and neutrophil-derived ROS, and inhibits NO metabolites and interferon-γ. Levofloxacin hydrochloride improves survival, alleviates lung injury, and reduces oxidative and inflammatory markers in influenza virus-infected mice. Levofloxacin hydrochloride inhibits lung cancer proliferation and xenograft tumor growth, and induces apoptosis and oxidative stress. Levofloxacin hydrochloride can be used in research on bacterial infection, influenza virus infection, atherosclerosis, and lung cancer. | ||||||||||||||||||||
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Levofloxacin hydrochloride (Standard) | 99.49% | Levofloxacin hydrochloride (Standard) is the analytical standard of Levofloxacin hydrochloride (HY-B0330B). This product is intended for research and analytical applications. Levofloxacin hydrochloride is an orally active broad-spectrum antibacterial agent with antioxidant and antibacterial activities. Levofloxacin hydrochloride upregulates TC synthesis-related genes and transport-related genes, reduces plasma PCSK9, inhibits GABAA receptors and mitochondrial complexes I/III, scavenges hydroxyl radicals and neutrophil-derived ROS, and inhibits NO metabolites and interferon-γ. Levofloxacin hydrochloride improves survival, alleviates lung injury, and reduces oxidative and inflammatory markers in influenza virus-infected mice. Levofloxacin hydrochloride inhibits lung cancer proliferation and xenograft tumor growth, and induces apoptosis and oxidative stress. Levofloxacin hydrochloride can be used in research on bacterial infection, influenza virus infection, atherosclerosis, and lung cancer. | ||||||||||||||||||||
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Levofloxacin-d8 hydrochloride | 99.0% | Levofloxacin-d8 hydrochloride is the deuterated-labeled Levofloxacin hydrochloride (HY-B0330B). Levofloxacin hydrochloride is an orally active broad-spectrum antibacterial agent with antioxidant and antibacterial activities. Levofloxacin hydrochloride upregulates TC synthesis-related genes and transport-related genes, reduces plasma PCSK9, inhibits GABAA receptors and mitochondrial complexes I/III, scavenges hydroxyl radicals and neutrophil-derived ROS, and inhibits NO metabolites and interferon-γ. Levofloxacin hydrochloride improves survival, alleviates lung injury, and reduces oxidative and inflammatory markers in influenza virus-infected mice. Levofloxacin hydrochloride inhibits lung cancer proliferation and xenograft tumor growth, and induces apoptosis and oxidative stress. Levofloxacin hydrochloride can be used in research on bacterial infection, influenza virus infection, atherosclerosis, and lung cancer. | ||||||||||||||||||||
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Levofloxacin-d3 hydrochloride | Levofloxacin-d3 hydrochloride is the deuterated-labeled Levofloxacin hydrochloride (HY-B0330B). Levofloxacin hydrochloride is an orally active broad-spectrum antibacterial agent with antioxidant and antibacterial activities. Levofloxacin hydrochloride upregulates TC synthesis-related genes and transport-related genes, reduces plasma PCSK9, inhibits GABAA receptors and mitochondrial complexes I/III, scavenges hydroxyl radicals and neutrophil-derived ROS, and inhibits NO metabolites and interferon-γ. Levofloxacin hydrochloride improves survival, alleviates lung injury, and reduces oxidative and inflammatory markers in influenza virus-infected mice. Levofloxacin hydrochloride inhibits lung cancer proliferation and xenograft tumor growth, and induces apoptosis and oxidative stress. Levofloxacin hydrochloride can be used in research on bacterial infection, influenza virus infection, atherosclerosis, and lung cancer. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-B0125Ofloxacin -
Similarity Score 0.98
HY-B0330Levofloxacin -
Similarity Score 0.98
HY-B0330D(R)-Ofloxacin -
Similarity Score 0.92
HY-W338859Levofloxacin mesylate -
Similarity Score 0.90
HY-119136BFF-122 -
Similarity Score 0.90
HY-B0013Lavofloxacin lactate -
Similarity Score 0.89
HY-W779275Levofloxacin impurity 14 -
Similarity Score 0.89
HY-B0330CLevofloxacin sodium -
Similarity Score 0.86
HY-W739930Desmethyl ofloxacin hydrochloride -
Explore the MedChemAI to find more analogs
References
- [1]. Enoki Y, et al. Pleiotropic Effects of Levofloxacin, Fluoroquinolone Antibiotics, against Influenza Virus-Induced Lung Injury. PloS one. 2015;10(6):e0130248.
- [2]. Sheng Q H, et al. Levofloxacin Ameliorates Atherosclerosis By Regulating Lipid Metabolism. 2025.
- [3]. Erden BF, et al. Antidepressant, anxiogenic, and antinociceptive properties of levofloxacin in rats and mice. Pharmacology, biochemistry, and behavior. 2001 Mar;68(3):435-41. [Content Brief]
- [4]. Song M, et al. Antibiotic drug levofloxacin inhibits proliferation and induces apoptosis of lung cancer cells through inducing mitochondrial dysfunction and oxidative damage. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2016 Dec;84:1137-1143. [Content Brief]
- [5]. JI B, et al. In vitro and in vivo activities of levofloxacin against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 1995 Jun;39(6):1341-4. [Content Brief]
