LIF-R/CD118
LIF-R/CD118 is the ligand-binding alpha subunit of the leukemia inhibitory factor receptor complex, encoded by LIFR and belonging to the gp130 family of type I cytokine receptors. Upon LIF binding, LIFR pairs with gp130 to activate JAK/STAT3, MAPK and PI3K pathways, and together with CNTFR the same machinery also responds to ciliary neurotrophic factor, oncostatin M, cardiotrophin-1 and related cytokines. LIFR signaling sustains pluripotency of mouse embryonic stem cells, supports trophoblast and bone biology and promotes neuronal survival. It is expressed on hematopoietic cells, osteoblasts, hepatocytes and neural tissue, and LIFR loss in some tumors reflects loss of metastasis-suppressing activity.
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LIF-R/CD118 Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
