1. Recombinant Proteins
  2. CD Antigens Receptor Proteins
  3. Epithelial cell CD Proteins
  4. LIF-R/CD118
  5. LIFR Protein, Human (HEK293, Fc)

LIFR Protein, Human (HEK293, Fc)

Cat. No.: HY-P77058
COA Handling Instructions

LIFR Protein, a signal-transducing molecule, potentially shares a common pathway with IL6ST. Its soluble form inhibits LIF binding to target cell receptors, reducing biological activity. LIFR forms a heterodimer with IL6ST, interacting with the CNTF and CNTFR complex, implying potential crosstalk and collaborative actions in cellular processes. LIFR Protein, Human (HEK293, Fc) is the recombinant human-derived LIFR protein, expressed by HEK293 , with C-hFc labeled tag.

For research use only. We do not sell to patients.

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  • Biological Activity

  • Technical Parameters

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Description

LIFR Protein, a signal-transducing molecule, potentially shares a common pathway with IL6ST. Its soluble form inhibits LIF binding to target cell receptors, reducing biological activity. LIFR forms a heterodimer with IL6ST, interacting with the CNTF and CNTFR complex, implying potential crosstalk and collaborative actions in cellular processes. LIFR Protein, Human (HEK293, Fc) is the recombinant human-derived LIFR protein, expressed by HEK293 , with C-hFc labeled tag.

Background

LIFR protein acts as a signal-transducing molecule that may share a common pathway with IL6ST. Its soluble form functions as an inhibitor by blocking the binding of LIF to receptors on target cells, thereby suppressing its biological activity. LIFR forms a heterodimer with IL6ST, and this heterodimer interacts with the complex formed by CNTF and CNTFR, suggesting potential crosstalk and collaborative actions in cellular processes.

Species

Human

Source

HEK293

Tag

C-hFc

Accession

P42702-1/NP_001121143.1 (M45-S833)

Gene ID
Molecular Construction
N-term
LIFR (M45-S833)
Accession # P42702-1/NP_001121143.1
hFc
C-term
Synonyms
Leukemia inhibitory factor receptor; LIF-R; CD118
Molecular Weight

Approximately 116.1 kDa.

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

LIFR Protein, Human (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
LIFR Protein, Human (HEK293, Fc)
Cat. No.:
HY-P77058
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