1. NF-κB
  2. Keap1-Nrf2

Keap1-Nrf2

Keap1-Nrf2 is the major regulator of cytoprotective responses to oxidative and electrophilic stress. Kelch-like ECH-associated protein 1 is a protein that in humans is encoded by the Keap1 gene. Keap1 has been shown to interact with Nrf2, a master regulator of the antioxidant response, which is important for the amelioration of oxidative stress. Under quiescent conditions, Nrf2 is anchored in the cytoplasm through binding to Keap1, which, in turn, facilitates the ubiquitination and subsequent proteolysis of Nrf2. Such sequestration and further degradation of Nrf2 in the cytoplasm are mechanisms for the repressive effects of Keap1 on Nrf2. because Nrf2 activation leads to a coordinated antioxidant and anti-inflammatory response, and Keap1 represses Nrf2 activation, Keap1 has become a very attractive drug target.

Keap1-Nrf2 Related Products (15):

Cat. No. Product Name Effect Purity
  • HY-13324
    Bardoxolone methyl Activator 98.59%
    Bardoxolone methyl(RTA 402; NSC 713200) is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs).
  • HY-N0005
    Curcumin Activator 99.68%
    Curcumin is a natural phenolic compound with impressive antioxidant properties, exerting chemopreventive effects partly through the activation of nuclear factor (erythroid-2 related) factor 2 (Nrf2).
  • HY-100523
    ML385 Inhibitor 99.59%
    ML385 is a novel and specific NRF2 inhibitor.
  • HY-14909
    Bardoxolone Activator 99.21%
    Bardoxolone is a novel nuclear regulator factor (Nrf-2) activator.
  • HY-17376
    Ezetimibe Activator 99.76%
    Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
  • HY-B2230
    Hinokitiol Inhibitor >98.0%
    Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, with anti-infective, anti-oxidative, and anti-tumor activities.
  • HY-17363
    Dimethyl fumarate Activator >98.0%
    Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression.
  • HY-12213
    CDDO-EA Activator 99.32%
    CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.
  • HY-12212
    RTA-408 Activator 98.96%
    RTA-408 is a synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 and inhibits the proinflammatory transcription factor NF-κB.
  • HY-19734
    NK-252 Activator 99.29%
    NK-252 is a Nrf2 activator, exhibits a greater Nrf2-activating potential than OPZ.
  • HY-N0198
    Nordihydroguaiaretic acid Activator 99.31%
    Nordihydroguaiaretic acid (NDGA) is a natural phenolic compound isolated from the creosote bush Larrea divaricata, which has anti-tumor activities both in vitro and in vivo.
  • HY-N0780
    Isoalantolactone Activator 99.92%
    Isoalantolactone, isolated from Inula spp.
  • HY-N1913
    Danshensu Activator >98.0%
    Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway.
  • HY-N0553
    Gypenoside XVII Activator >98.0%
    Gypenoside XVII is a natural product.
  • HY-17376S
    Ezetimibe D4
    Ezetimibe D4 is the deuterium labeled Ezetimibe.