1. NF-κB
  2. Keap1-Nrf2

Keap1-Nrf2

Keap1-Nrf2 is the major regulator of cytoprotective responses to oxidative and electrophilic stress. Kelch-like ECH-associated protein 1 is a protein that in humans is encoded by the Keap1 gene. Keap1 has been shown to interact with Nrf2, a master regulator of the antioxidant response, which is important for the amelioration of oxidative stress. Under quiescent conditions, Nrf2 is anchored in the cytoplasm through binding to Keap1, which, in turn, facilitates the ubiquitination and subsequent proteolysis of Nrf2. Such sequestration and further degradation of Nrf2 in the cytoplasm are mechanisms for the repressive effects of Keap1 on Nrf2. because Nrf2 activation leads to a coordinated antioxidant and anti-inflammatory response, and Keap1 represses Nrf2 activation, Keap1 has become a very attractive drug target.

Keap1-Nrf2 Related Products (13):

Cat. No. Product Name Effect Purity
  • HY-N0005
    Curcumin Activator
    Curcumin is a natural phenolic compound with impressive antioxidant properties, exerting chemopreventive effects partly through the activation of nuclear factor (erythroid-2 related) factor 2 (Nrf2).
  • HY-17376
    Ezetimibe Activator
    Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe (Eze) is a potent cholesterol absorption inhibitor.
  • HY-13324
    Bardoxolone methyl Activator
    Bardoxolone (methyl) is a potent activator of the nuclear factor erythroid 2-related factor 2 (Nrf2), and uesd for antioxidative and anti-inflammatory treatment. 
  • HY-14909
    Bardoxolone Activator
    Bardoxolone is a novel nuclear regulator factor (Nrf-2) activator.
  • HY-12213
    CDDO-EA Activator
    CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.
  • HY-12212
    RTA-408 Inhibitor
    RTA-408 is a synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 and inhibits the proinflammatory transcription factor NF-(kappa)B.
  • HY-17363
    Dimethyl fumarate Activator
    Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression.
  • HY-19734
    NK-252 Activator
    NK-252 is a Nrf2 activator, exhibits a greater Nrf2-activating potential than OPZ.
  • HY-N0780
    Isoalantolactone Inhibitor
    Isoalantolactone, isolated from Inula spp.
  • HY-N1913
    Danshensu Activator
    Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway.
  • HY-N0198
    Nordihydroguaiaretic acid Activator
    Nordihydroguaiaretic acid (NDGA) is a natural phenolic compound isolated from the creosote bush Larrea divaricata, which has anti-tumor activities both in vitro and in vivo.
  • HY-N0553
    Gypenoside XVII Activator
    Gypenoside XVII is a natural product.
  • HY-17376S
    Ezetimibe D4
    Ezetimibe D4 is the deuterium labeled Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.