1. NF-κB
  2. Keap1-Nrf2

Keap1-Nrf2

Keap1-Nrf2 is the major regulator of cytoprotective responses to oxidative and electrophilic stress. Kelch-like ECH-associated protein 1 is a protein that in humans is encoded by the Keap1 gene. Keap1 has been shown to interact with Nrf2, a master regulator of the antioxidant response, which is important for the amelioration of oxidative stress. Under quiescent conditions, Nrf2 is anchored in the cytoplasm through binding to Keap1, which, in turn, facilitates the ubiquitination and subsequent proteolysis of Nrf2. Such sequestration and further degradation of Nrf2 in the cytoplasm are mechanisms for the repressive effects of Keap1 on Nrf2. because Nrf2 activation leads to a coordinated antioxidant and anti-inflammatory response, and Keap1 represses Nrf2 activation, Keap1 has become a very attractive drug target.

Keap1-Nrf2 Related Products (18):

Cat. No. Product Name Effect Purity
  • HY-100523
    ML385 Inhibitor 99.59%
    ML385 is a novel and specific NRF2 inhibitor.
  • HY-N0005
    Curcumin Activator 99.66%
    Curcumin is a natural phenolic compound with impressive antioxidant properties, acts as a p300/CREB-binding protein inhibitor of histone acetyltransferase activity, and also activates nuclear factor (erythroid-2 related) factor 2 (Nrf2).
  • HY-13324
    Bardoxolone methyl Activator 98.59%
    Bardoxolone (methyl) is a potent activator of the nuclear factor erythroid 2-related factor 2 (Nrf2), and uesd for antioxidative and anti-inflammatory treatment. 
  • HY-15725
    CDDO-Im Activator 98.20%
    CDDO-Im (CDDO-imidazolide) is an activator of Nrf2 and PPAR, with Kis of 232 and 344 nM for PPARα and PPARγ, also has anti-cancer and anti-inflammatory activities.
  • HY-17363
    Dimethyl fumarate Activator >98.0%
    Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression.
  • HY-101140
    KI696 Inhibitor
    KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction.
  • HY-19543
    Brusatol Inhibitor
    Brusatol, isolated from the Brucea javanica plant, inhibits Nrf2.
  • HY-12212
    RTA-408 Activator 98.96%
    RTA-408 is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO).
  • HY-14909
    Bardoxolone Activator 99.21%
    Bardoxolone is a novel nuclear regulator factor (Nrf-2) activator.
  • HY-17376
    Ezetimibe Activator 99.76%
    Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe (Eze) is a potent cholesterol absorption inhibitor.
  • HY-19734
    NK-252 Activator 99.29%
    NK-252 is a potential Nrf2 activator, which exhibits a great Nrf2-activating potential.
  • HY-12213
    CDDO-EA Activator 99.32%
    CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.
  • HY-N1913
    Danshensu Activator >98.0%
    Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway.
  • HY-14645A
    (+)-DHMEQ Activator 98.02%
    (+)-DHMEQ is an activator of antioxidant transcription factor Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ inhibits NF-kB than its enantiomer (+)-DHMEQ.
  • HY-N0290
    Mangiferin Activator 99.88%
    Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50.
  • HY-B2230
    Hinokitiol Inhibitor >98.0%
    Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, with anti-infective, anti-oxidative, and anti-tumor activities.
  • HY-N0606
    Ginsenoside Rh3 Activator >98.0%
    Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5. Ginsenoside Rh3 treatment in human retinal cells induces Nrf2 activation.
  • HY-17376S
    Ezetimibe D4
    Ezetimibe D4 is the deuterium labeled Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
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