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TBHQ (Synonyms: tert-Butylhydroquinone)

Cat. No.: HY-100489 Purity: >98.0%
Data Sheet SDS Handling Instructions

TBHQ is a phenolic antioxidant, a selective inducer of Nrf2 in a preclinical model of ICH.

For research use only. We do not sell to patients.
TBHQ Chemical Structure

TBHQ Chemical Structure

CAS No. : 1948-33-0

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10 mM * 1 mL in DMSO $55 In-stock
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Description

TBHQ is a phenolic antioxidant, a selective inducer of Nrf2 in a preclinical model of ICH.( Intracerebral hemorrhage ). In vivo :The administration of TBHQ enhanced the DNA-binding activity of Nrf2 in the brain and reduced oxidative brain damage in comparison to vehicle-treated ICH. TBHQ treatment reduced microglial activation with concomitant reduction in the release of proinflammatory cytokine interleukin-1β (IL-1 β). TBHQ treatment attenuated neurodegeneration and improved neurological outcomes after ICH.[1] TBHQ increase the nuclear accumulation of Nrf2 and the Nrf2-regulated gene expression, including heme oxygenase-1 (HO-1) and NAD(P)H. Knocking out Nrf2 in mice abolish the protective effect of TBHQ on the DOX-induced cardiotoxicity. [2]

References
M.Wt

166.22

Formula

C₁₀H₁₄O₂

CAS No.

1948-33-0

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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TBHQ
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