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TBHQ (Synonyms: tert-Butylhydroquinone)

Cat. No.: HY-100489 Purity: >98.0%
Handling Instructions

TBHQ is a phenolic antioxidant, a selective inducer of Nrf2 in a preclinical model of ICH.

For research use only. We do not sell to patients.

TBHQ Chemical Structure

TBHQ Chemical Structure

CAS No. : 1948-33-0

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
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Estimated Time of Arrival: December 31
1 g USD 60 In-stock
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Estimated Time of Arrival: December 31
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Customer Review

    TBHQ purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2018 Jun 7;500(3):790-796.

    Macrophages are isolated from wild-type mice, treated with tBHQ (100 μM) or not, and induced for 3 h using LPS, IFN-g, IL-4 or IL-13. Western blot analysis of the expression of Nrf2, p65 subunit of NF-kB, phosphorylated p65 and PPARg in the cytoplasm and nucleus.

    TBHQ purchased from MCE. Usage Cited in: Front Pharmacol. 2018 Jun 6;9:540.

    BHQ promotes higher protein expression of Nrf2 in a time-dependent manner in neonatal rat cardiac fibroblasts (NRCF) while notably downregulated collagen I and collagen III.
    • Biological Activity

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    Description

    TBHQ is a phenolic antioxidant, a selective inducer of Nrf2 in a preclinical model of ICH.( Intracerebral hemorrhage ). In vivo :The administration of TBHQ enhanced the DNA-binding activity of Nrf2 in the brain and reduced oxidative brain damage in comparison to vehicle-treated ICH. TBHQ treatment reduced microglial activation with concomitant reduction in the release of proinflammatory cytokine interleukin-1β (IL-1 β). TBHQ treatment attenuated neurodegeneration and improved neurological outcomes after ICH.[1] TBHQ increase the nuclear accumulation of Nrf2 and the Nrf2-regulated gene expression, including heme oxygenase-1 (HO-1) and NAD(P)H. Knocking out Nrf2 in mice abolish the protective effect of TBHQ on the DOX-induced cardiotoxicity. [2]

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 56.66 mg/mL (340.87 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 6.0161 mL 30.0806 mL 60.1612 mL
    5 mM 1.2032 mL 6.0161 mL 12.0322 mL
    10 mM 0.6016 mL 3.0081 mL 6.0161 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    166.22

    Formula

    C₁₀H₁₄O₂

    CAS No.

    1948-33-0

    SMILES

    OC1=CC=C(O)C=C1C(C)(C)C

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

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    Product Name:
    TBHQ
    Cat. No.:
    HY-100489
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    TBHQ

    Cat. No.: HY-100489