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Fragment Library

83 Cited Publications
Customer Review

Based on 83 publication(s) in Google Scholar

Fragment-based drug discovery (FBDD) is well suited for discovering both drug leads and chemical probes of protein function; it can cover broad swaths of chemical space and allows the use of creative chemistry. Fragment-based drug discovery is well-established in industry and has resulted in a variety of drugs entering clinical trials, with two, vemurafenib and venetoclax, already approved. FBDD also has key attractions for academia. Notably, it is able to tackle difficult or novel targets for which no chemical matter may be found in existing HTS collections.

MCE designs a unique collection of 41,368 fragment compounds, all of which obey a heuristic rule called the “Rule of Three (RO3) ”, in which molecular weight ≤300 Da, the number of hydrogen bond donors (H-donors) ≤3, the number of hydrogen bond acceptors (H-acceptors) is ≤3 and cLogP is ≤3. This library is an important source of lead-like drugs.

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Virtual Screening
Cell-based Compound Screening
Affinity Mass Spectrometry Drug Screening
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Compound Screening Libraries

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Description & Advantages

•   A unique collection of 41,368 fragment compounds for traditional lead identification via high-throughput screening (HTS).

•   The compounds follow the Rule of Three.

•   A useful tool for the fragment-based approach to drug discovery (FBDD).

•   More detailed compound information with structure, Molecular Weight, cLogP, H-donor and H-acceptor number.

•   NMR and HPLC validated ensure high purity.

•   All compounds are in stock and continuously updated.

Parameter Range Average Value
Molecular Weight ≤300 181.43
cLogP ≤3.0 1.6105
H-donors ≤3.0 2.07
H-acceptors ≤3.0 0.78

Product Details

Formulation

A collection of 41,368 fragment compounds supplied as pre-dissolved Solutions or Solid

Solution: 41,368 compounds supplied in 10 mM solution.

Container

96- or 384-well Plate with Peelable Foil Seal

Storage
-80°C
Shipping
Blue ice or dry ice

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200 mg
USD 120
In-stock
Estimated to ship on August 31 More）
500 mg
Get Quote
Consult sales personnel for more information
Bulk Inquiry
500 mg
Get Quote
Consult sales personnel for more information
Bulk Inquiry
Estimated to ship on August 31 More）
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