1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)

Phosphodiesterase (PDE)

Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators ofsignal transduction mediated by these second messenger molecules.

Phosphodiesterase (PDE) Related Products (85):

Cat. No. Product Name Effect Purity
  • HY-12318
    IBMX Inhibitor 99.88%
    IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50 of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, PDE4 and PDE5, respectively.
  • HY-14992
    Bay 60-7550 Inhibitor 98.12%
    Bay 60-7550 is a selective inhibitor of PDE2 with Ki of 3.8±0.2 nM, also is a modulator of NO.
  • HY-16900
    Rolipram Inhibitor 99.56%
    Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
  • HY-12085
    Apremilast Inhibitor 99.87%
    Apremilast is a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors.
  • HY-10978
    AN-2728 Inhibitor 99.95%
    AN-2728 is a potent inhibitor of PDE4 and cytokine release; inhibit PDE4 with an IC50 of 0.49 μM.
  • HY-101772
    GLPG1690 Inhibitor 98.39%
    GLPG1690 is a first-in-class autotaxin (ATX) inhibitor, with IC50 of 131 nM and Ki of 15 nM.
  • HY-12740
    RVT-501 Inhibitor >98.0%
    RVT-501 (E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.8 nM.
  • HY-103050
    ML-030 Inhibitor 99.32%
    ML-030 is a potent PDE4 inhibitor, with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM for PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2, respectively.
  • HY-15441
    PF-04447943 Inhibitor 99.77%
    PF-04447943 is a potent inhibitor of human recombinant PDE9A (IC50=12 nM) with >78-fold selectivity, respectively, over other PDE family members (IC50>1000 nM).
  • HY-15025A
    Sildenafil citrate Inhibitor 99.84%
    Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM.
  • HY-17464
    Cilostazol Inhibitor 99.34%
    Cilostazol(OPC 13013; OPC 21) is a potent inhibitor of PDE3A, the isoform of PDE 3 in the cardiovascular system (IC50=0.2 uM).
  • HY-13344
    PF-8380 Inhibitor 98.49%
    PF-8380 is a potent autotaxin inhibitor with an IC50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood.
  • HY-14252
    Milrinone Inhibitor 99.78%
    Milrinone is a PDE3 inhibitor, and also an inotrope and vasodilator.
  • HY-15426
    PF-04957325 Inhibitor 98.48%
    PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50 values of 0.7 nM for PDE8A and less than 0.3 nM for PDE8B.
  • HY-12472
    TAK-063 Inhibitor 98.04%
    TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs.
  • HY-B0763
    Ibudilast Inhibitor 99.83%
    Ibudilast(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor which has been marketed for treating asthma.
  • HY-B0809
    Theophylline Inhibitor 99.58%
    Theophylline is a methylated xanthine derivative; competitive nonselective phosphodiesterase inhibitor and nonselective adenosine receptor antagonist.
  • HY-10469
    GSK256066 Inhibitor 98.46%
    GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.
  • HY-15747
    Deltarasin Inhibitor
    Deltarasin is an inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
  • HY-15455
    Roflumilast Inhibitor 99.87%
    Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.