1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Zatolmilast

Zatolmilast  (Synonyms: BPN14770)

Cat. No.: HY-117571 Purity: 98.98%
COA Handling Instructions

Zatolmilast (BPN14770) is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively.

For research use only. We do not sell to patients.

Zatolmilast Chemical Structure

Zatolmilast Chemical Structure

CAS No. : 1606974-33-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 250 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 250 In-stock
5 mg USD 280 In-stock
10 mg USD 520 In-stock
25 mg USD 990 In-stock
50 mg USD 1600 In-stock
100 mg USD 2250 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


Zatolmilast (BPN14770) is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively[1].

IC50 & Target[1]


7.4 nM (IC50)


7.8 nM (IC50)

In Vivo

Zatolmilast increases brain cAMP, increases phosphorylation of CREB and increases production of brain-derived neurotrophic factor (BDNF) in hippocampus[1].
Zatolmilast (0.1-30 mg/kg; p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition (NOR) at doses above 0.3 mg/kg[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl6 mice[2]
Dosage: 0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration: p.o.; 24 hours
Result: Significantly improved novel object discrimination at doses above 0.3 mg/kg.
Clinical Trial
Molecular Weight









Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 260 mg/mL (640.71 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4643 mL 12.3213 mL 24.6427 mL
5 mM 0.4929 mL 2.4643 mL 4.9285 mL
10 mM 0.2464 mL 1.2321 mL 2.4643 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (5.35 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (5.35 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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