1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. BPN14770

BPN14770 

Cat. No.: HY-117571
Handling Instructions

BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3 (two different dimeric forms of PDE4D), respectively.

For research use only. We do not sell to patients.

BPN14770 Chemical Structure

BPN14770 Chemical Structure

CAS No. : 1606974-33-7

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Description

BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3 (two different dimeric forms of PDE4D), respectively[1].

IC50 & Target[1]

PDE4D3

7.4 nM (IC50)

PDE4D7

7.8 nM (IC50)

In Vivo

BPN14770 increases brain cAMP, increases phosphorylation of CREB and increases production of brain-derived neurotrophic factor (BDNF) in hippocampus[1].
BPN14770 (0.1-30 mg/kg; p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition (NOR) at doses above 0.3 mg/kg[2].

Animal Model: C57Bl6 mice[2]
Dosage: 0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration: p.o.; 24 hours
Result: Significantly improved novel object discrimination at doses above 0.3 mg/kg.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

405.80

Formula

C₂₁H₁₅ClF₃NO₂

CAS No.

1606974-33-7

SMILES

O=C(O)CC1=CC=C(CC2=CC(C3=CC=CC(Cl)=C3)=NC(C(F)(F)F)=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

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BPN14770
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HY-117571
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BPN14770

Cat. No.: HY-117571