1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. BPN14770

BPN14770 

Cat. No.: HY-117571 Purity: 99.39%
Handling Instructions

BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively.

For research use only. We do not sell to patients.

BPN14770 Chemical Structure

BPN14770 Chemical Structure

CAS No. : 1606974-33-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1  mL in DMSO USD 250 In-stock
Estimated Time of Arrival: December 31
5 mg USD 280 In-stock
Estimated Time of Arrival: December 31
10 mg USD 520 In-stock
Estimated Time of Arrival: December 31
25 mg USD 990 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1600 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively[1].

IC50 & Target[1]

PDE4D3

7.4 nM (IC50)

PDE4D7

7.8 nM (IC50)

In Vivo

BPN14770 increases brain cAMP, increases phosphorylation of CREB and increases production of brain-derived neurotrophic factor (BDNF) in hippocampus[1].
BPN14770 (0.1-30 mg/kg; p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition (NOR) at doses above 0.3 mg/kg[2].

Animal Model: C57Bl6 mice[2]
Dosage: 0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration: p.o.; 24 hours
Result: Significantly improved novel object discrimination at doses above 0.3 mg/kg.
Clinical Trial
Molecular Weight

405.80

Formula

C₂₁H₁₅ClF₃NO₂

CAS No.

1606974-33-7

SMILES

O=C(O)CC1=CC=C(CC2=CC(C3=CC=CC(Cl)=C3)=NC(C(F)(F)F)=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 260 mg/mL (640.71 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4643 mL 12.3213 mL 24.6427 mL
5 mM 0.4929 mL 2.4643 mL 4.9285 mL
10 mM 0.2464 mL 1.2321 mL 2.4643 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (5.35 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (5.35 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BPN14770BPN 14770BPN-14770Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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Product name:
BPN14770
Cat. No.:
HY-117571
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