2. 疾患領域
  3. Urogenital Disease
  4. Male Reproductive System Disease

Male Reproductive System Disease

Male reproductive system disease encompasses a range of disorders affecting organs and functions involved in male fertility and sexual health, including erectile dysfunction, premature ejaculation, low libido, testicular lumps, prostate disease, and infertility. These conditions may arise from physiological factors such as aging, kidney failure, and medication use (e.g., antidepressants), as well as psychological factors like stress and anxiety. Symptoms can include testicular pain, perineal discomfort, nipple discharge, and difficulties with sexual performance or conception. Genetic factors, such as variants in the MIR199A1 gene, and pathways involving p53 regulation and immune response may contribute to disease development. The prostate and bone are commonly affected tissues, and treatments may involve hormonal agents like progesterone and dydrogesterone. Early recognition and medical evaluation are crucial for effective management.

 

Male Reproductive System Disease (29):

製品番号 製品名 CAS 番号 純度 構造式
  • HY-12723
    Apomorphine 58-00-4 99.48%
    Apomorphine ((-)-Apomorphine) is a potent dopamine receptor agonist. Apomorphine also inhibit MAO-A and MAO-B. Apomorphine exerts neuroprotective effect and can relax rat corpus cavernosum. Apomorphine can inhibit ROS production, DNA fragmentation and inibit JNK and ERK1/2 phosphorylation. Apomorphine can enhance degradation of intracellular Aβ40 and Aβ42, reduces tau protein levels and inhibit MMP-9 expression. Apomorphine is a highly potent radical scavenger and iron chelator. Apomorphine can be used for the researches of dementia, parkinson's disease, alzheimer disease, breast carcinoma, and erectile dysfunction.
    Apomorphine
  • HY-12717
    Phentolamine 50-60-2 99.94%
    Phentolamine is an orally active, selective α1 and α2 Adrenergic receptor antagonist. Phentolamine antagonizes the vasodilatory effect of Cromakalim (HY-110011) on isolated circumflex coronary artery segments in dogs. Phentolamine reduces systemic vascular resistance and increases cardiac output. Phentolamine improves erectile dysfunction. Phentolamine can be used for the research of erectile dysfunction.
    Phentolamine
  • HY-W583749
    6:2 Cl-PFAES 73606-19-6 99.98%
    6:2 Cl-PFAES is an orally effective alternative to Perfluorooctane sulfonate. 6:2 Cl-PFAES significantly inhibits the growth of zebrafish and induces reproductive toxicity. 6:2 Cl-PFAES reduces the relative weights of epididymis and testis in male BALB/c mice. 6:2 Cl-PFAES can be used in the chrome plating industry.
    6:2 Cl-PFAES
  • HY-12717A
    Phentolamine hydrochloride

    Phentolamine (hydrochloride)

    		73-05-2 99.91%
    Phentolamine hydrochloride is an orally active, selective α1 and α2 Adrenergic receptor antagonist. Phentolamine hydrochloride antagonizes the vasodilatory effect of Cromakalim (HY-110011) on isolated circumflex coronary artery segments in dogs. Phentolamine hydrochloride reduces systemic vascular resistance and increases cardiac output. Phentolamine hydrochloride improves erectile dysfunction. Phentolamine hydrochloride can be used for the research of erectile dysfunction.
    Phentolamine hydrochloride
  • HY-Y0284
    Diethyl phthalate 84-66-2 99.87%
    Diethyl phthalate is an orally active plasticizer and detergent base. Diethyl phthalate increases the activities of ACP, ALP, SDH, and ALT in liver, muscle, or both tissues. Diethyl phthalate induces dose-dependent mortality and sluggish behavior in freshwater fish. Diethyl phthalate may induce male reproductive toxicity. Diethyl phthalate is added to plastic polymers to help maintain their flexibility.
    Diethyl phthalate
  • HY-114797
    PDE5-IN-16 261769-44-2
    PDE5-IN-16 is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 0.8 nM. PDE5-IN-16 enhances the relaxation of corpus cavernosum tissue strips. PDE5-IN-16 is applicable for the research of erectile dysfunction.
    PDE5-IN-16
  • HY-18740
    Trequinsin 79855-88-2
    Trequinsin (HL 725 free base) is a PDE inhibitor, CatSper channel activator, and sperm potassium channel modulator. Trequinsin targets PDE3 with an IC50 of <1 nM. Trequinsin enhances currents and elevates intracellular calcium and cGMP levels via direct activation of the CatSper channel, while inhibiting the outward current conductance of sperm potassium channels. Without inducing premature acrosome reaction, Trequinsin significantly enhances sperm hyperactivated motility, forward motility, and the ability to penetrate viscous media. Trequinsin exerts age-specific positive inotropic and positive lusitropic effects on rabbit ventricular papillary muscles. Trequinsin has been used in studies on the mechanisms underlying male infertility (e.g., asthenozoospermia).
    Trequinsin
  • HY-182244
    SERT/NET-IN-1
    SERT/NET-IN-1 is a blood-brain barrier-permeable SERT and NET inhibitor, with an IC50 of 11.2 nM against human SERT and an IC50 of 32.0 nM against human NET. SERT/NET-IN-1 blocks 5-HT reuptake to enhance serotonergic signaling. SERT/NET-IN-1 also blocks norepinephrine reuptake to enhance central noradrenergic transmission and inhibits the ejaculatory reflex. SERT/NET-IN-1 prolongs ejaculatory latency, reduces ejaculation frequency and preserves sexual function. SERT/NET-IN-1 exhibits cross-species microsomal metabolic stability, shows acceptable oral brain exposure in rats, and has favorable safety profiles. SERT/NET-IN-1 can be used in studies related to premature ejaculation.
    SERT/NET-IN-1
  • HY-116392B
    DL-threo-PDMP hydrochloride 80938-69-8 99.40%
    DL-threo-PDMP hydrochloride is a competitive glucosylceramide synthase (GCS) inhibitor and antimalarial agent. DL-threo-PDMP hydrochloride competitively inhibits the activity of GCS. DL-threo-PDMP hydrochloride restores cisplatin sensitivity in cisplatin-resistant testicular germ cell tumor cells. DL-threo-PDMP hydrochloride blocks the growth of ring-stage Plasmodium falciparum parasites.
    DL-threo-PDMP hydrochloride
  • HY-W338584
    Hydroxycitric acid tripotassium 232281-44-6 98.0%
    Tripotassium hydroxycitrate is an orally active, multi-target, multi-bioactive organic acid. Tripotassium hydroxycitrate activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Tripotassium hydroxycitrate activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Tripotassium hydroxycitrate activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation.
    Hydroxycitric acid tripotassium
  • HY-W073128
    Perfluorotetradecanoic acid 376-06-7 98.0%
    Perfluorotetradecanoic acid (PFTeDA) is an orally active perfluoroalkyl substance. Perfluorotetradecanoic acid directly binds to the ligand-binding domain of purified hPPARγ, with a Kd value of 157.8 μM. Perfluorotetradecanoic acid significantly reduces the activity of the SIRT1/PGC1α and AMPK signaling pathways while stimulating the activity of the AKT1/mTOR signaling pathway. Perfluorotetradecanoic acid significantly upregulates the expression of corticosterone biosynthesis genes. Perfluorotetradecanoic acid increases ROS levels and promotes Apoptosis. Perfluorotetradecanoic acid impairs Leydig cell function and male reproductive endocrine function in adult male rats.
    Perfluorotetradecanoic acid
  • HY-N13015
    Quercetin 5-O-β-D-glucopyranoside 34199-21-8 98%
    Quercetin 5-O-β-D-glucopyranoside is a glycosylated flavonoid metabolite and flavonoid compound. Quercetin 5-O-β-D-glucopyranoside can be produced by microbial transformation of Quercetin (HY-18085) via Mucor hiemalis. Quercetin 5-O-β-D-glucopyranoside can be used in studies related to benign prostatic hyperplasia.
    Quercetin 5-O-β-D-glucopyranoside
  • HY-183986
    SR210831C
    SR210831C is a highly selective, orally active retinoic acid receptor α (RARα) inhibitor with an IC50 of 0.051 nM. SR210831C suppresses spermatogenesis by reducing sperm count in house mice via acting on the early stages of spermatogenesis, and it does not cross the blood-testis barrier. SR210831C can be used in male contraception research.
    SR210831C
  • HY-P0267A
    Melanotan (MT)-II acetate 1036322-26-5
    Melanotan (MT)-II acetate is a melanocortin receptor agonist that crosses the blood-brain barrier. Melanotan (MT)-II acetate activates melanocortin receptor 3 and melanocortin receptor 4, and stimulates the release of central endogenous oxytocin. Melanotan (MT)-II acetate reverses recognition memory impairment, increased anxiety levels and reduced exploratory tendency in zebrafish exposed to short-term high-fat diet. Melanotan (MT)-II acetate improves impaired social behavior indicators in mouse models of autism spectrum disorder. Melanotan (MT)-II acetate induces weight loss, reduces food intake and exerts anorectic effects. Melanotan (MT)-II acetate increases intracavernous pressure and erectile activity in brown rats. Melanotan (MT)-II acetate can be used in studies related to memory impairment, anxiety, reduced exploratory behavior, autism spectrum disorder, obesity and erectile dysfunction.
    Melanotan (MT)-II acetate
  • HY-B1509B
    Trypaflavin bromide 857613-80-0
    Trypaflavin bromide is an orally active acridine compound and antimalarial agent. Trypaflavin bromide invades germ cells. Trypaflavin bromide induces aberrations in unfertilized oocytes. Trypaflavin bromide increases the frequency of chromosomal aberrations. Trypaflavin bromide shows weak mutagenicity. Trypaflavin bromide is highly toxic to Leishmania, causing immediate lysis of the leptomonads.
    Trypaflavin bromide
  • HY-114921
    α-(2-Carboxycyclopropyl)glycine 22255-17-0
    α-(2-Carboxycyclopropyl)glycine is a male sterilant. α-(2-Carboxycyclopropyl)glycine does not affect IAA (HY-18569B)-induced ethylene formation, does not induce ethylene biosynthesis, and resists conversion to ethylene in vitro or in wheat coleoptile segments.
    α-(2-Carboxycyclopropyl)glycine
  • HY-181774
    PDE4/5-IN-1 1807631-43-1
    PDE4/5-IN-1 is a selective phosphodiesterase 4/5 (PDE4/5) dual inhibitor. PDE4/5-IN-1 functionally inhibits PDE5, PDE4B2, and PDE4D2 activity. PDE4/5-IN-1 relaxes isolated rat prostate tissue, enhances nitric oxide-induced relaxation in isolated rat prostate tissue, and reduces alpha-1 adrenoceptor-mediated contractile responses in isolated rat prostate tissue. PDE4/5-IN-1 inhibits proliferation of human hyperplastic prostate cells. PDE4/5-IN-1 can be used for the research of benign prostatic hyperplasia.
    PDE4/5-IN-1
  • HY-12723R
    Apomorphine (Standard) 58-00-4
    Apomorphine ((-)-Apomorphine) (Standard) is the analytical standard of Apomorphine (HY-12723). This product is intended for research and analytical applications. Apomorphine is a potent dopamine receptor agonist. Apomorphine also inhibit MAO-A and MAO-B. Apomorphine exerts neuroprotective effect and can relax rat corpus cavernosum. Apomorphine can inhibit ROS production, DNA fragmentation and inibit JNK and ERK1/2 phosphorylation. Apomorphine can enhance degradation of intracellular Aβ40 and Aβ42, reduces tau protein levels and inhibit MMP-9 expression. Apomorphine is a highly potent radical scavenger and iron chelator. Apomorphine can be used for the researches of dementia, parkinson's disease, alzheimer disease, breast carcinoma, and erectile dysfunction.
    Apomorphine (Standard)
  • HY-171129
    EP055 2411173-40-3
    EP055 is a non-hormonal male contraceptive. EP055 targets to sperm protein EPPIN and inhibits anti-EPPIN antibodies from binding EPPIN with an IC50 of 1121 μM. EP055 can inhibit sperm motility (IC50 = 199.5 μM) by reducing the internal pH and Ca2+ levels of the sperm, thereby causing the sperm to aggregate. EP055 can be used for development of male contraceptive.
    EP055
  • HY-B1509A
    Trypaflavin 86-40-8
    Trypaflavin is an acridine compound and antimalarial agent. Trypaflavin invades germ cells. Trypaflavin induces aberrations in unfertilized oocytes. Trypaflavin increases the frequency of chromosomal aberrations. Trypaflavin shows weak mutagenicity. Trypaflavin is highly toxic to Leishmania, causing immediate lysis of the leptomonads.
    Trypaflavin