2. Neuronal Signaling Anti-infection
  3. Glucosylceramide Synthase (GCS) Parasite
  4. DL-threo-PDMP hydrochloride

DL-threo-PDMP hydrochloride is a competitive glucosylceramide synthase (GCS) inhibitor and antimalarial agent. DL-threo-PDMP hydrochloride competitively inhibits the activity of GCS. DL-threo-PDMP hydrochloride restores cisplatin sensitivity in cisplatin-resistant testicular germ cell tumor cells. DL-threo-PDMP hydrochloride blocks the growth of ring-stage Plasmodium falciparum parasites.

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DL-threo-PDMP hydrochloride

DL-threo-PDMP hydrochloride Chemical Structure

CAS No. : 80938-69-8

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Based on 1 publication(s) in Google Scholar

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DL-threo-PDMP hydrochloride Related Antibodies

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Description

DL-threo-PDMP hydrochloride is a competitive glucosylceramide synthase (GCS) inhibitor and antimalarial agent. DL-threo-PDMP hydrochloride competitively inhibits the activity of GCS. DL-threo-PDMP hydrochloride restores cisplatin sensitivity in cisplatin-resistant testicular germ cell tumor cells. DL-threo-PDMP hydrochloride blocks the growth of ring-stage Plasmodium falciparum parasites[1][2].

IC50 & Target[1]

Plasmodium

 

In Vitro

DL-threo-PDMP (30 μmol/L; 48 h) hydrochloride restores cisplatin sensitivity in cisplatin-resistant SuSaR testicular germ cell tumor cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DL-threo-PDMP hydrochloride Related Antibodies

Cell Viability Assay[1]

Cell Line: SuSaR (cisplatin-resistant human nonseminomatous testicular germ cell teratocarcinoma cell line)
Concentration: 30 μmol/L (combined with cisplatin treatment)
Incubation Time: 48 h (combined with cisplatin treatment)
Result: Reduced the cisplatin IC50 in SuSaR cells from 2.72 ± 0.16 μg/mL to 1.22 ± 0.22 μg/mL, resulting in 44.8% cisplatin resensitization.
Significantly increased intracellular ceramide levels in SuSaR cells compared to control, cisplatin alone, or DL-threo-PDMP alone.
In Vivo

DL-threo-PDMP (hydrochloride) (50 mg/kg; i.p.; daily; 21 days) alone does not reduce cisplatin-refractory testicular germ cell tumor weight in nude mice, but when combined with cisplatin (3.5 mg/kg; i.v.; once weekly; 3 consecutive weeks), it resensitizes the tumors, producing 42.8% to 73.5% tumor weight reduction and a 2.7- to 2.81-fold increase in apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice[1]
Dosage: 50 mg/kg (single agent; combined with cisplatin 3.5 mg/kg)
Administration: i.p.; daily; 21 days; 1 hour before cisplatin (i.v.; once weekly; 3 consecutive weeks) for combined group
Result: Did not produce a significant reduction in tumor weight compared to vehicle-treated animals as a single agent.
Produced significant tumor weight reductions of 42.8% in TGT1XR tumors and 73.5% in TGT38XR tumors compared to vehicle controls when combined with cisplatin.
Induced a 2.7-fold increase in apoptotic cells (caspase-3 positive) in TGT1XR tumors and a 2.81-fold increase in TGT38XR tumors compared to cisplatin-only treatment when combined with cisplatin.
Molecular Weight

427.02

Formula

C23H39ClN2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H](C1=CC=CC=C1)[C@H](NC(CCCCCCCCC)=O)CN2CCOCC2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (234.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3418 mL 11.7091 mL 23.4181 mL
5 mM 0.4684 mL 2.3418 mL 4.6836 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: 99.40%

SDS (252 KB)

COA (245 KB) HNMR (311 KB) LCMS (333 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3418 mL 11.7091 mL 23.4181 mL 58.5453 mL
5 mM 0.4684 mL 2.3418 mL 4.6836 mL 11.7091 mL
10 mM 0.2342 mL 1.1709 mL 2.3418 mL 5.8545 mL
15 mM 0.1561 mL 0.7806 mL 1.5612 mL 3.9030 mL
20 mM 0.1171 mL 0.5855 mL 1.1709 mL 2.9273 mL
25 mM 0.0937 mL 0.4684 mL 0.9367 mL 2.3418 mL
30 mM 0.0781 mL 0.3903 mL 0.7806 mL 1.9515 mL
40 mM 0.0585 mL 0.2927 mL 0.5855 mL 1.4636 mL
50 mM 0.0468 mL 0.2342 mL 0.4684 mL 1.1709 mL
60 mM 0.0390 mL 0.1952 mL 0.3903 mL 0.9758 mL
80 mM 0.0293 mL 0.1464 mL 0.2927 mL 0.7318 mL
100 mM 0.0234 mL 0.1171 mL 0.2342 mL 0.5855 mL
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DL-threo-PDMP hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-threo-PDMP80938-69-8Glucosylceramide Synthase (GCS)Parasitecisplatintubovesicular membrane networkglucosylceramide synthaseepithelial ovarian cancersphingomyelin synthasenonseminomatous testicular germ cell tumorsPlasmodium falciparum-infected erythrocytescisplatin-resistant germline-derived orthoxenograftsmalariaPlasmodium falciparum ring-stage parasitesInhibitorinhibitorinhibit

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