2. Disease Areas
  3. Infection
  4. Parasitic Infection
  5. Plasmodium Infection

Plasmodium Infection

Plasmodium infection is caused by a genus of apicomplexan parasites, with four species—Plasmodium falciparum, P. vivax, P. ovale, and P. malariae—responsible for human malaria. P. falciparum is the most severe and potentially fatal form. The disease affects millions annually, resulting in 1–2 million deaths, primarily in tropical regions. Clinical manifestations include fever, chills, headache, diarrhea, anemia, and complications involving the lungs, kidneys, and central nervous system. The parasite exhibits a complex life cycle involving sexual reproduction in mosquitoes and asexual replication in humans. Plasmodium possesses two essential endosymbiont-derived organelles: mitochondria and the apicoplast. The apicoplast, though reduced to a 35 kb genome and non-photosynthetic, plays vital roles in metabolic pathways. The mitochondria are highly specialized, with a minimal 6 kb genome and unique metabolic adaptations due to reductive evolution; they lack key enzymes like pyruvate dehydrogenase and complex I (NDH1). In mosquito stages, oxidative phosphorylation occurs using alternative substrates such as 2-oxoglutarate and a single-subunit flavoprotein (NDH2), whereas in human blood stages, mitochondrial activity is down-regulated and energy production relies predominantly on glycolysis.

References:

Plasmodium Infection (70):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-116392B
    DL-threo-PDMP hydrochloride 80938-69-8 99.40%
    DL-threo-PDMP hydrochloride is a competitive glucosylceramide synthase (GCS) inhibitor and antimalarial agent. DL-threo-PDMP hydrochloride competitively inhibits the activity of GCS. DL-threo-PDMP hydrochloride restores cisplatin sensitivity in cisplatin-resistant testicular germ cell tumor cells. DL-threo-PDMP hydrochloride blocks the growth of ring-stage Plasmodium falciparum parasites.
    DL-threo-PDMP hydrochloride
  • HY-129651
    SHMT-IN-1 1508286-18-7 99.86%
    SHMT-IN-1 is a Plasmodium falciparum Serine Hydroxymethyltransferase (PfSHMT) inhibitor with an IC50 of 350 nM. SHMT-IN-1 can be used for the research of malaria.
    SHMT-IN-1
  • HY-N1457
    Chrysosplenetin 603-56-5 99.84%
    Chrysosplenetin is an orally active polymethoxyflavone. Chrysosplenetin exerts anticancer effects by inhibiting topoisomerase, protecting DNA and inducing apoptosis. Chrysosplenetin acts as an antimalarial sensitizer, reverses Artemisinin (HY-B0094) resistance by inhibiting and downregulating P-glycoprotein, and enhances the efficacy of Artemisinin. Chrysosplenetin promotes bone formation by activating the Wnt/β-catenin pathway and exerts anti-osteoporotic effects.
    Chrysosplenetin
  • HY-N7935
    Procyanidin B5 12798-57-1
    Procyanidin B5 is an antioxidant with a IC50 of 0.1 mM in lipid peroxidation assays using mouse liver homogenates. Procyanidin B5 scavenges superoxide anions and hydroxyl radicals, and inhibits lipid peroxidation. Procyanidin B5 can be used in research related to cardiovascular diseases, cancer, and malaria.
    Procyanidin B5
  • HY-100662
    Didesethyl chloroquine 4298-14-0 99.91%
    Didesethyl chloroquine (Bisdesethylchloroquine) is the major metabolite of the antimalarial agent Chloroquine (HY-17589A). Didesethyl chloroquine is a potent myocardial inhibitor. Didesethyl chloroquine reduces calcium binding and accumulation in cardiac mitochondria, induces mitochondrial swelling, rupture and membrane conformational changes. Didesethyl chloroquine inhibits the growth of Plasmodium falciparum strains. Didesethyl chloroquine can be used in research related to malaria, chikungunya virus infection, and cardiovascular and cerebrovascular diseases.
    Didesethyl chloroquine
  • HY-W010354
    2,2-Diethoxyethanol 621-63-6
    2,2-Diethoxyethanol is a drug intermediate used in research related to Plasmodium falciparum infection.
    2,2-Diethoxyethanol
  • HY-W653841
    Chondroitin sulfate A disodium 39455-18-0
    Chondroitin sulfate A disodium is a mucopolysaccharide extracted from animal cartilages such as porcine nasal cartilage, and serves as a major structural component of cartilage. Chondroitin sulfate A disodium is one of the specific receptors for the adhesion of Plasmodium falciparum-infected red blood cells in the microcirculation. Chondroitin sulfate A disodium can be used together with selenium to prepare nanoparticles for protecting cartilage against T‑2 toxin-induced damage. Chondroitin sulfate A disodium is abnormally highly expressed in ameloblastoma, and is particularly enriched in stellate reticulum-like tumor cells. Chondroitin sulfate A disodium can be applied to studies on Plasmodium infection mechanisms, cartilage protection and oral tumors.
    Chondroitin sulfate A disodium
  • HY-N18356
    Europetin 16280-27-6
    Europetin (7-O-Methylmyricetin) is a natural product. Europetin can be isolated from the peels of Citrus aurantifolia. Europetin shows no antiplasmodial activity against Plasmodium falciparum NF54 with an IC50 > 50 μM. Europetin can be used for the research of malaria.
    Europetin
  • HY-148178
    MMV688533 2260904-47-8 99.50%
    MMV688533 is an antimalarial agent. MMV688533 interferes with intracellular trafficking, lipid utilization, and endocytosis pathways in Plasmodium falciparum. MMV688533 rapidly kills asexual blood-stage Plasmodium falciparum and Plasmodium vivax parasites in vitro and reduces parasitemia in a Plasmodium falciparum NSG mouse model. MMV688533 can be used for the research of malaria.
    MMV688533
  • HY-169790
    Phomarin 6866-87-1 98.53%
    Phomarin is an inhibitor for dihydrofolate reductase (DHFR). Phomarin exhibits activity against Plasmodium parasites and fungi including Mycrobotryum violaceum and Botrytis cinerea. Phomarin can be used for the research of malaria and fungal infections.
    Phomarin
  • HY-N2891
    Aristolactam A II 53948-07-5
    Aristolactam A II (Aristololactam A II) is a weak COX inhibitor with cytotoxic and anti-plasmodial activities. Aristolactam A II exhibits inhibitory activity against Chloroquine (HY-17589A)-sensitive strains, and exerts its inhibitory effect on Plasmodium falciparum growth by inducing cell membrane damage marked by LDH release. Aristolactam A II can be applied to the research of malaria-related mechanisms.
    Aristolactam A II
  • HY-N11173A
    trans-Melilotoside 618-67-7 99.79%
    trans-Melilotoside is a coumarin precursor and that can be isolated from Melilotus neapolitan. trans-Melilotoside exhibits antiparasitic and DPPH radical-scavenging activity. trans-Melilotoside can be used for the research of human african trypanosomiasis, chagas’ disease, malaria[1][3].
    trans-Melilotoside
  • HY-151574
    PfGSK3/PfPK6-IN-1 2797225-49-9 99.38%
    PfGSK3/PfPK6-IN-1 is a dual Plasmodium serine/threonine kinase inhibitor, with an IC50 of 97 nM against PfGSK3 and 8 nM against PfPK6 of Plasmodium falciparum. PfGSK3/PfPK6-IN-1 inhibits the proliferation of blood-stage parasites of Plasmodium falciparum 3D7. PfGSK3/PfPK6-IN-1 shows low cytotoxicity to hepatocytes at a concentration of 200 nM, and reduces cell viability at a concentration of 2 μM. PfGSK3/PfPK6-IN-1 is applicable to malaria-related research.
    PfGSK3/PfPK6-IN-1
  • HY-170780A
    (S)-DSM1465 3109381-05-4
    (S)-DSM1465 is a Plasmodium dihydroorotate dehydrogenase (DHODH) inhibitor. (S)-DSM1465 exhibits potential inhibitory activity against Plasmodium falciparum and Plasmodium vivax, and can be used in malaria research.
    (S)-DSM1465
  • HY-186055
    Antimalarial agent 58 1258387-05-1
    Antimalarial agent 58 is a diaminoquinoline methanol compound with weak in vitro activity against Plasmodium falciparum strain D6, and no activity against Plasmodium falciparum strains W2, C235 and C2A.
    Antimalarial agent 58
  • HY-W357093
    2-Chloro-2-deoxy-D-glucose 14685-79-1
    2-Chloro-2-deoxy-D-glucose is a 2-substituted glucose analog. 2-Chloro-2-deoxy-D-glucose inhibits the in vitro growth of P. falciparum. 2-Chloro-2-deoxy-D-glucose against a CQR strain with an IC50 value of 8.5 nM at the glucose concentration 5 mM.
    2-Chloro-2-deoxy-D-glucose
  • HY-164686
    MMV019662 896349-19-2
    MMV019662 is a PfNCR1 inhibitor. MMV019662 specifically interact with PfNCR1. MMV019662 induces opening of the SSD. MMV019662 can be used in the research of Plasmodium falciparum infection.
    MMV019662
  • HY-W109038
    4-Propylcatechol 2525-02-2 99.74%
    4-Propylcatechol is an Allylpyrocatechol (HY-124127) analog. 4-Propylcatechol shows anti-malarial activity against Plasmodium falciparum CDC-1 with an IC50 of 32 µM.
    4-Propylcatechol
  • HY-N7583
    Norcaesalpinin E 854038-96-3
    Norcaesalpinin E, a C-17-norcassane-type diterpene found in Caesalpinia crista, is a Plasmodium falciparum growth inhibitor with an IC50 of 90 nM. Norcaesalpinin E induces dose-dependent growth inhibition of Plasmodium falciparum. Norcaesalpinin E can be used for the research of malaria.
    Norcaesalpinin E
  • HY-N9551
    Eriodictyol chalcone 14917-41-0
    Eriodictyol chalcone is an antioxidant that inhibits multiple key enzymes including 5-LOX (IC50=0.043 μM), aromatase/CYP19A1 (IC50=2.8 μM), PTPase 1B (IC50=1.26 μM), and COX (IC50=34 μM). Eriodictyol chalcone exhibits excellent free radical scavenging activity. Eriodictyol chalcone not only inhibits the growth of plasmodia and enhances the efficacy of Artemisinin (HY-B0094), but also reduces depression-like behaviors in animal models. Eriodictyol chalcone serves as a biosynthetic precursor for Aureusidin (HY-N9834). Eriodictyol chalcone is a potential dietary supplement and herbicide, and it can be applied to research on malaria, depression, breast cancer and other related diseases.
    Eriodictyol chalcone