Eschweilenol C 

Eschweilenol C is a selective Plasmodium falciparum growth inhibitor. Eschweilenol C disrupts haemoglobin metabolism, reduces haemozoin production, kills Plasmodium falciparum ring and trophozoite stages. Eschweilenol C can be used for the research of inflammatory disorders and malaria^[1][2].

Eschweilenol C (72 h) potently inhibits the growth of PfDd2, Pf3D7, and mutant-resistant PfDd2-GNF156 Plasmodium falciparum asexual blood stages with IC₅₀ values ranging from 379.21 nM to 490.74 nM and a low resistance index of 1.29^[2].
Eschweilenol C (1-5 μg/mL; 48 h) is inactive against late-stage IV/V Plasmodium falciparum NF54-E gametocytes, with an IC₅₀ greater than 5 μg/mL^[2].
Eschweilenol C is non-toxic to Vero, Raw 264.7, and O⁺ human red blood cells, with high selectivity indices (SI > 10) against Plasmodium falciparum asexual blood stages^[2].
Eschweilenol C (72 h) significantly inhibits haemozoin production by Plasmodium falciparum at its PfDd2 IC₅₀ concentration of 490.74 nM^[2].
Eschweilenol C (24-72 h) acts slowly against Plasmodium falciparum PfDd2, with an IC₅₀ of 557.66 nM at 48 h and no measurable IC₅₀ at 24 h^[2].
Eschweilenol C preferentially inhibits Plasmodium falciparum PfDd2 ring and trophozoite stages (82.13% and 85.01% growth inhibition, respectively) with a parasiticidal effect, and has weaker activity against schizonts (58.88% growth inhibition) with a parasitostatic effect^[2].
Eschweilenol C displays strong binding affinity with Plasmodium falciparum PfM1AAP (-8.7 kcal/mol) and PfM17LAP (-8.3 kcal/mol)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

448.33

C₂₀H₁₆O₁₂

211371-02-7

Solid

White to off-white

OC(C1=C2C3=C(C(O)=C(C=C3C(O1)=O)O)O4)=C(O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)O)O)O)C=C2C4=O

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Rodrigues de Araújo A, et al. Antifungal and anti-inflammatory potential of eschweilenol C-rich fraction derived from Terminalia fagifolia Mart. J Ethnopharmacol. 2019;240:111941.

  [2]. Tali MBT, et al. Eschweilenol C and subfractions from Terminalia plants disrupt haemoglobin metabolism, inhibiting Plasmodium falciparum growth at rings and trophozoite stages. Malar J. 2025;24(1):422. Published 2025 Nov 24.