Eschweilenol C
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Eschweilenol C is a selective Plasmodium falciparum growth inhibitor. Eschweilenol C disrupts haemoglobin metabolism, reduces haemozoin production, kills Plasmodium falciparum ring and trophozoite stages. Eschweilenol C can be used for the research of inflammatory disorders and malaria.
For research use only. We do not sell to patients.
- CAS No.: 211371-02-7
- Formula: C20H16O12
- Molecular Weight:448.33
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Parasite Isoforms
More
Biological Activity
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Plasmodium |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | IC50 |
88 μg/mL
Compound: 2
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Cytotoxicity against mouse B16 cells after 3 days by MTT assay
Cytotoxicity against mouse B16 cells after 3 days by MTT assay
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[PMID: 12762821] |
| HeLa | IC50 |
86.5 μg/mL
Compound: 2
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Cytotoxicity against human HeLa cells after 3 days by MTT assay
Cytotoxicity against human HeLa cells after 3 days by MTT assay
|
[PMID: 12762821] |
| K562 | IC50 |
67 μg/mL
Compound: 2
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Cytotoxicity against adriamycin-resistant human K562 cells after 3 days by MTT assay
Cytotoxicity against adriamycin-resistant human K562 cells after 3 days by MTT assay
|
[PMID: 12762821] |
| K562 | IC50 |
82 μg/mL
Compound: 2
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Cytotoxicity against human K562 cells after 3 days by MTT assay
Cytotoxicity against human K562 cells after 3 days by MTT assay
|
[PMID: 12762821] |
| KB | IC50 |
98 μg/mL
Compound: 2
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Cytotoxicity against human KB cells after 3 days by MTT assay
Cytotoxicity against human KB cells after 3 days by MTT assay
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[PMID: 12762821] |
| P388 | IC50 |
53 μg/mL
Compound: 2
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Cytotoxicity against adriamycin-resistant mouse P388 cells after 3 days by MTT assay
Cytotoxicity against adriamycin-resistant mouse P388 cells after 3 days by MTT assay
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[PMID: 12762821] |
| P388 | IC50 |
62 μg/mL
Compound: 2
|
Cytotoxicity against mouse P388 cells after 3 days by MTT assay
Cytotoxicity against mouse P388 cells after 3 days by MTT assay
|
[PMID: 12762821] |
Eschweilenol C (72 h) potently inhibits the growth of PfDd2, Pf3D7, and mutant-resistant PfDd2-GNF156 Plasmodium falciparum asexual blood stages with IC50 values ranging from 379.21 nM to 490.74 nM and a low resistance index of 1.29[2].
Eschweilenol C (1-5 μg/mL; 48 h) is inactive against late-stage IV/V Plasmodium falciparum NF54-E gametocytes, with an IC50 greater than 5 μg/mL[2].
Eschweilenol C is non-toxic to Vero, Raw 264.7, and O+ human red blood cells, with high selectivity indices (SI > 10) against Plasmodium falciparum asexual blood stages[2].
Eschweilenol C (72 h) significantly inhibits haemozoin production by Plasmodium falciparum at its PfDd2 IC50 concentration of 490.74 nM[2].
Eschweilenol C (24-72 h) acts slowly against Plasmodium falciparum PfDd2, with an IC50 of 557.66 nM at 48 h and no measurable IC50 at 24 h[2].
Eschweilenol C preferentially inhibits Plasmodium falciparum PfDd2 ring and trophozoite stages (82.13% and 85.01% growth inhibition, respectively) with a parasiticidal effect, and has weaker activity against schizonts (58.88% growth inhibition) with a parasitostatic effect[2].
Eschweilenol C displays strong binding affinity with Plasmodium falciparum PfM1AAP (-8.7 kcal/mol) and PfM17LAP (-8.3 kcal/mol)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 211371-02-7
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Appearance Solid
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Molecular Weight 448.33
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Formula C20H16O12
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Color White to off-white
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SMILES
OC(C1=C2C3=C(C(O)=C(C=C3C(O1)=O)O)O4)=C(O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)O)O)O)C=C2C4=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
References
[1]. Rodrigues de Araújo A, et al. Antifungal and anti-inflammatory potential of eschweilenol C-rich fraction derived from Terminalia fagifolia Mart. J Ethnopharmacol. 2019;240:111941. [Content Brief]
[2]. Tali MBT, et al. Eschweilenol C and subfractions from Terminalia plants disrupt haemoglobin metabolism, inhibiting Plasmodium falciparum growth at rings and trophozoite stages. Malar J. 2025;24(1):422. Published 2025 Nov 24. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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