1. Signaling Pathways
  2. Anti-infection
  3. Parasite
  4. Amebae Isoform

Amebae

The free-living amebae (FLA) are found in both the natural environment and in man-made facilities and may occasionally be human parasites. While many FLA have been identified, the three main genera associated with human disease are Acanthamoeba spp., Balamuthia mandrillaris and Naegleria fowleri. Infection with N. fowleri is exceedingly rare and is not common in immunocompromised hosts. Both Acanthamoeba species and B. mandrillaris cause granulomatous amebic encephalitis (GAE), primarily in immunocompromised hosts, while Acanthamoeba spp. can also cause a localized infection of the eye, referred to as amebic keratitis (AK).

The life cycle of both FLAs involves two forms: an actively dividing trophozoite stage and a dormant cyst stage. Trophozoites are uninucleate, divide through binary fission, and feed on surrounding bacteria and algae through phagocytosis or pseudopod formation. If environmental conditions become challenging (e.g., desiccation, osmolarity imbalance, nutrient deprivation, etc.), trophozoites will encyst and become resistant to most antimicrobials and biocides. Cysts remain viable for years and will yield pathogenic trophozoites. Of note, the virulence of excysted trophozoites decreases with duration of encystment. While the trophozoite stage is the infectious form, infection can also be acquired through contact with cysts which will subsequently excyst under amenable conditions. Exposure to both organisms is thought to be due to inhalation of the organism into the lower respiratory tract and/or contamination of broken skin.

Amebae Related Products (16):

Cat. No. Product Name Effect Purity
  • HY-B0751
    Fumagillin
    Inhibitor ≥99.0%
    Fumagillin(NSC9168) is an antimicrobial compound first isolated in 1949 from the fungus Aspergillus fumigatu.
  • HY-B0963
    Cloxiquine
    Inhibitor ≥98.0%
    Cloxiquine (5-Chloro-8-quinolinol) is an antibacterial, antifungal and antiamoebic agent.
  • HY-B0956
    Paromomycin sulfate
    Inhibitor ≥98.0%
    Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects.
  • HY-119972
    Diloxanide
    Inhibitor 99.71%
    Diloxanide is an anti-protozoal agent and can be used for the research of asymptomatic-intestinal amebiasis caused by Entamoeba histolytica or some other protozoal infections.
  • HY-B1147
    Diloxanide furoate
    Inhibitor 99.80%
    Diloxanide furoate is the prodrug of Diloxanide.
  • HY-B1118A
    Secnidazole hemihydrate
    Inhibitor
    Secnidazole (RP-14539) hemihydrate is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence.
  • HY-B1118S1
    Secnidazole-13C2, 15N2
    Inhibitor
    Secnidazole-13C2, 15N2 is the 13C2, 15N2 labeled Secnidazole.
  • HY-N10471
    F3226-1387
    Inhibitor
    F3226-1387 is a potent Entamoeba histolytica O-acetylserine sulfhydrylase EhOASS3 inhibitor with an IC50 value of 38 μM.
  • HY-115249
    Metronidazole acetic acid
    Inhibitor 98.18%
    Metronidazole acetic acid is a metabolite of Metronidazole with mutagenic activity in bacteria.
  • HY-15537
    Tilbroquinol
    Inhibitor 98.33%
    Tilbroquinol is an orally active antiparasite agent, can be used in study of amoebiasis.
  • HY-101715
    Panidazole
    Inhibitor 98.77%
    Panidazole is an amoebicide.
  • HY-B1118
    Secnidazole
    Inhibitor 99.88%
    Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence.
  • HY-B1118S
    Secnidazole-d6
    Inhibitor
    Secnidazole-d6 (RP-14539-d6) is the deuterium labeled Secnidazole.
  • HY-N2023A
    Thalifendine chloride
    Inhibitor
    Thalifendine chloride is a metabolite of Berberine (HY-N0716), with antiplasmodial and antiamoebic activities.
  • HY-119826
    Quinfamide
    Quinfamide is an antiamebic agent.
  • HY-126406
    Tirandamycin A
    Inhibitor
    Tirandamycin A, an antibiotic, is a bacterial RNA polymerase inhibitor.