1. Anti-infection
  2. Parasite
  3. Diloxanide furoate

Diloxanide furoate 

Cat. No.: HY-B1147
Handling Instructions

Diloxanide furoate is the prodrug of Diloxanide. Diloxanide furoate is a potent and orally active anti-protozoal agent and can be used for the research of amebiasis, mild intestinal amebiasis or asymptomatic cyst carriers.

For research use only. We do not sell to patients.

Diloxanide furoate Chemical Structure

Diloxanide furoate Chemical Structure

CAS No. : 3736-81-0

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50 mg USD 250 In-stock
Estimated Time of Arrival: December 31
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Description

Diloxanide furoate is the prodrug of Diloxanide. Diloxanide furoate is a potent and orally active anti-protozoal agent and can be used for the research of amebiasis, mild intestinal amebiasis or asymptomatic cyst carriers[1].

In Vitro

Diloxanide furoate (1.95-2.5 μg/ml) has potent activity against different strains of E. histolytica, it is against BYso (grown with bacteria), SFL3 (grown with Chrithidia sp.), and SFL3 (grown axenically) with MIC values of 2.5 μg/ml, 2.5 μg/ml and 1.95 μg/ml, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED50 value is 77.9 mg/kg for this agent in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Weanling Wistar rats[2]
Dosage: 200 mg/kg; 150 mg/kg; 100 mg/kg; 75 mg/kg
Administration: Oral administraion; 75-200 mg/kg; 3 days; once daily
Result: Was against intestinal (caecal) amoebiasis in rats.
Molecular Weight

328.15

Formula

C₁₄H₁₁Cl₂NO₄

CAS No.
SMILES

O=C(C1=CC=CO1)OC2=CC=C(N(C(C(Cl)Cl)=O)C)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (152.37 mM)

Ethanol : 20 mg/mL (60.95 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0474 mL 15.2369 mL 30.4739 mL
5 mM 0.6095 mL 3.0474 mL 6.0948 mL
10 mM 0.3047 mL 1.5237 mL 3.0474 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.62 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.80%

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Keywords:

Diloxanide furoateParasiteAnti-Protozoal Agentanti-protozoalEntamoeba histolyticainfectionluminal amebicideamoebic colitisInhibitorinhibitorinhibit

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Diloxanide furoate
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HY-B1147
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