1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. URAT1

URAT1

Urate transporter 1; SLC22A12

URAT1, a member of the OAT (organic anion transporter) family was first cloned from the human kidney, where it is localized to the apical (brush border) membrane of renal proximal tubular cells. URAT1 mediates the reabsorption of uric acid, thereby regulating blood uric acid concentrations. Impairment in URAT1 activity, either due to polymorphisms, or drug-drug interactions, can have toxicological consequences. In the kidney, URAT1 is distributed along the renal tubular cell membrane and involved in reabsorption and excretion of uric acid, organic acids, drugs and their metabolites. Uric acid is taken up by OAT1 and OAT3 from the blood and reabsorbed into renal tubular cells via URAT1, in exchange for dicarboxylic acid. URAT1, along with OAT4 mediates uptake of uric acid from the renal tubule into renal tubular cells in exchange for organic anions such as lactic acid and nicotinic acid. This exchange is electroneutral and can be trans-stimulated by Cl- gradients and gradients of lactate transported by the sodium-monocarboxylate transporter. In the salivary glands, URAT1 is distributed along the entire surface, including the ductal and acinar cells, suggesting a role in the transport of organic acids and uric acid in the whole salivary gland.

URAT1 Related Products (22):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15258
    Lesinurad
    Inhibitor 99.93%
    Lesinurad is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 µM, respectively.
    Lesinurad
  • HY-16733
    Verinurad
    Inhibitor 99.18%
    Verinurad (RDEA3170) is a highly potent and specific URAT1 inhibitor with an IC50 of 25 nM.
    Verinurad
  • HY-15258A
    Lesinurad sodium
    Inhibitor 99.97%
    Lesinurad sodium is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 µM, respectively.
    Lesinurad sodium
  • HY-W011711
    Benzarone
    Inhibitor 99.67%
    Benzarone (Fragivix) is a potent human uric acid transporter 1 (hURAT1) inhibitor, with an IC50 of 2.8 μM in oocyte. Benzarone could lower uric acid serum levels.
    Benzarone
  • HY-111345
    Epaminurad
    Inhibitor 99.75%
    Epaminurad (UR-1102) is an orally active, potent and selective URAT1 (urate transporter 1) inhibitor, with a Ki of 0.057 μM. Epaminurad quite modestly inhibits OAT1 and OAT3 (organic anion transporter). Epaminurad is a uricosuric agent. Epaminurad can be used for gout and hyperuricemia research.
    Epaminurad
  • HY-160265
    URAT1 inhibitor 9
    Inhibitor
    URAT1 inhibitor 9 (Compound 24) is an URAT1 inhibitor that can be used in the study of gout or hyperuricemia.
    URAT1 inhibitor 9
  • HY-157306
    HC-1310
    HC-1310 URAT1 Inhibitor (Compound 83) is a potent URAT1 inhibitor and can be used for research on hyperuricemia and gout.
    HC-1310
  • HY-147422
    Xininurad
    Inhibitor 99.59%
    Xininurad (XNW3009) is a urate transporter (URAT) inhibitor
    Xininurad
  • HY-144305
    KPH2f
    Inhibitor 98.05%
    KPH2f is a safe, orally active, and effective dual URAT1/GLUT9 inhibitor with IC50s of 0.24 μM and 9.37 μM for URAT1 and GLUT9, respectively. KPH2f shows little effects on OAT1 and ABCG2 (IC50=32.14 and 26.74 μM).
    KPH2f
  • HY-151432
    URAT1 inhibitor 3
    Inhibitor 98.02%
    URAT1 inhibitor 3 is a potent, orally active, selective URAT1 inhibitor with an IC50 value of 0.8 nM. URAT1 inhibitor 3 has urate-lowering efficacy. URAT1 inhibitor 3 can be used in research of gout and hyperuricemi.
    URAT1 inhibitor 3
  • HY-W052011
    Ruzinurad
    Inhibitor 99.05%
    Ruzinurad (HR011303) is a highly selective URATl inhibitor (WO2020088641, compound I). Ruzinurad can be used in the study of hyperuricemia.
    Ruzinurad
  • HY-153968
    URAT1&XO inhibitor 1
    Inhibitor 99.56%
    URAT1&XO inhibitor 1 (compound 29) is a dual inhibitor of both URAT1 (IC50=~10 μM) and Xanthine Oxidase (IC50=1.01 μM). URAT1&XO inhibitor 1 results hypouricemic effect in potassium oxonate-induced hyperuricemia rat model. URAT1&XO inhibitor 1 is used for hyperuricemia research.
    URAT1&XO inhibitor 1
  • HY-114309
    URAT1 inhibitor 1
    Inhibitor
    URAT1 inhibitor 1 (1g) is a uric acid transporter 1 (URAT1) inhibitor, with an IC50 of 32 nM. URAT1 inhibitor 1 has potential to treat hyperuricemia associated with gout.
    URAT1 inhibitor 1
  • HY-147300
    Puliginurad
    Inhibitor 99.96%
    Puliginurad (YL-90148) is a potent urate transporter (URAT) inhibitor. Puliginurad can be used for hyperuricemia and gout research.
    Puliginurad
  • HY-153969
    URAT1 inhibitor 6
    Inhibitor 99.01%
    URAT1 inhibitor 6 (Compound 1h) is a potent URAT1 inhibitor (IC50: 35 nM for hURAT1). URAT1 inhibitor 6 is 200- and 8-fold more potent than parent Lesinurad (HY-15258) and Benzbromarone (HY-B1135). URAT1 inhibitor 6 can be used for research of inflammation.
    URAT1 inhibitor 6
  • HY-153971
    URAT1 inhibitor 8
    Inhibitor 98.01%
    URAT1 inhibitor 8 (example 247) is a potent URAT1 inhibitor, with an IC50 of 0.001 μM. URAT1 inhibitor 8 can be used for gout research.
    URAT1 inhibitor 8
  • HY-156624
    Lingdolinurad
    Inhibitor
    Lingdolinurad is urate transporter inhibitor, targeting to hURAT1.Lingdolinurad can be used for research in hyperuricemia in vitro and in vivo.
    Lingdolinurad
  • HY-153970
    URAT1 inhibitor 7
    Inhibitor
    URAT1 inhibitor 7 (compound 10f) is a potent URAT1 inhibitor, with an IC50 of 12 nM. URAT1 inhibitor 7 exhibits microsomal stability (HLM <13 µL/min/mg). URAT1 inhibitor 7 also inhibits CYP2C9, with an IC50 of 4.2 μM. URAT1 inhibitor 7 can be used for gout research.
    URAT1 inhibitor 7
  • HY-152033
    URAT1 inhibitor 4
    Inhibitor
    URAT1 inhibitor 4, a Lesinurad derivative, is a potent and orally active URAT1 inhibitor with an IC50 of 7.56 μM. URAT1 inhibitor 4 has higher in vivo urate-lowering efficacy than Lesinurad (HY-15258).
    URAT1 inhibitor 4
  • HY-143906
    URAT1 inhibitor 2
    Inhibitor
    URAT1 inhibitor 2 is an orally active and potent URAT1 and CYP isozyme inhibitor, with IC50 values of 1.36 μM, 16.97 μM, 5.22 μM for URAT1-mediated 14C-UA uptake, CYP1A2 and CYP2C9, respectively. URAT1 inhibitor 2 is a promising agent candidate in the study of hyperuricemia and gout.
    URAT1 inhibitor 2