country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-183658

Copy Link Print Information

URAT1/GLUT9-IN-3

URAT1/GLUT9-IN-3 is an orally active URAT1/GLUT9 dual inhibitor with IC₅₀ values of 4.01 and 1.60 μM. URAT1/GLUT9-IN-3 inhibits URAT1-mediated uric acid uptake and GLUT9-mediated uric acid transport, reducing renal urate reabsorption. URAT1/GLUT9-IN-3 reduces serum uric acid levels in hyperuricemic mice. URAT1/GLUT9-IN-3 can be used for the researches of gout and hyperuricemia.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₉H₂₅BrN₄O₃S₃
분자량:653.63

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

URAT1/GLUT9-IN-3 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

GLUT9

1.6 μM (IC₅₀)

All GLUT Isoforms :

In Vitro

URAT1/GLUT9-IN-3 (Compound 17) potently inhibits human URAT1 with an IC₅₀ of 4.01 μM^[1].
URAT1/GLUT9-IN-3 potently inhibits GLUT9 with an IC₅₀ of 1.60 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	AUC_0-t	AUC_0-∞	MRT_0-∞	T_1/2	T_max	C_max	CL	F
Rat^[1]	2 mg/kg	i.v.	5380 ng·h/mL	5400 ng·h/mL	0.60 h	1.20 h	0.083 h	12100 ng/mL	374 mL/h/kg	/
Rat^[1]	20 mg/kg	p.o.	18100 ng·h/mL	18200 ng·h/mL	3.20 h	1.70 h	2.33 h	4930 ng/mL	/	33.71 %

In Vivo

URAT1/GLUT9-IN-3 (Compound 17) (0.5-2 mg/kg; p.o.) reduces serum uric acid levels in acute hyperuricemic mice by up to 82.4% at an oral dose of 2 mg/kg, with efficacy maintained at lower doses down to 0.5 mg/kg^[1].
URAT1/GLUT9-IN-3 (1000 mg/kg; p.o.; single dose) shows no acute toxicity at an oral dose of 1000 mg/kg in healthy Kunming mice and exhibits favorable tolerance with no significant tissue damage following 14 days of daily oral dosing at 50 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Hyperuricemic mice (Male)^[1]
Dosage:

0.5 mg/kg; 1 mg/kg; 2 mg/kg
Administration:

p.o.
Result:

Reduced serum uric acid (SUA) levels to 267 μM, corresponding to a decrease ratio (DR) of 82.1%.
Reduced SUA levels to 371 μM, corresponding to a DR of 70.2%.
Reduced SUA levels to 582 μM, corresponding to a DR of 47.6%.
Reduced SUA levels to 273 μM, corresponding to a DR of 82.4%.

Chemical Information

분자량 653.63
화학식 C₂₉H₂₅BrN₄O₃S₃
SMILES

O=C(CCCSC1=NC2=C(C(NC3=C4C(C=CC=C4)=C(C=C3)C5CC5)=N1)SC=C2)NS(C6=CC=C(C=C6)Br)(=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Yang Q, et al. Discovery of a Novel Thienopyrimidine Derivative as a Potent Dual URAT1/GLUT9 Inhibitor with Enhanced Urate-Lowering Efficacy, Superior Pharmacokinetics, and Favorable Safety Profile for Gout and Hyperuricemia. J Med Chem. Published online May 6, 2026. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

URAT1/GLUT9-IN-3

All GLUT Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

URAT1/GLUT9-IN-3 Related Classifications

HY-183658 Related Classifications