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Art. -Nr.: HY-183658

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URAT1/GLUT9-IN-3

URAT1/GLUT9-IN-3 is an orally active URAT1/GLUT9 dual inhibitor with IC₅₀ values of 4.01 and 1.60 μM. URAT1/GLUT9-IN-3 inhibits URAT1-mediated uric acid uptake and GLUT9-mediated uric acid transport, reducing renal urate reabsorption. URAT1/GLUT9-IN-3 reduces serum uric acid levels in hyperuricemic mice. URAT1/GLUT9-IN-3 can be used for the researches of gout and hyperuricemia.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₉H₂₅BrN₄O₃S₃
Molecular Weight:653.63

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

URAT1/GLUT9-IN-3 Chemical Structure

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

GLUT9

1.6 μM (IC₅₀)

Alle GLUT Isoform-spezifische Produkte anzeigen :

In Vitro

URAT1/GLUT9-IN-3 (Compound 17) potently inhibits human URAT1 with an IC₅₀ of 4.01 μM^[1].
URAT1/GLUT9-IN-3 potently inhibits GLUT9 with an IC₅₀ of 1.60 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	AUC_0-t	AUC_0-∞	MRT_0-∞	T_1/2	T_max	C_max	CL	F
Rat^[1]	2 mg/kg	i.v.	5380 ng·h/mL	5400 ng·h/mL	0.60 h	1.20 h	0.083 h	12100 ng/mL	374 mL/h/kg	/
Rat^[1]	20 mg/kg	p.o.	18100 ng·h/mL	18200 ng·h/mL	3.20 h	1.70 h	2.33 h	4930 ng/mL	/	33.71 %

In Vivo

URAT1/GLUT9-IN-3 (Compound 17) (0.5-2 mg/kg; p.o.) reduces serum uric acid levels in acute hyperuricemic mice by up to 82.4% at an oral dose of 2 mg/kg, with efficacy maintained at lower doses down to 0.5 mg/kg^[1].
URAT1/GLUT9-IN-3 (1000 mg/kg; p.o.; single dose) shows no acute toxicity at an oral dose of 1000 mg/kg in healthy Kunming mice and exhibits favorable tolerance with no significant tissue damage following 14 days of daily oral dosing at 50 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Hyperuricemic mice (Male)^[1]
Dosage:

0.5 mg/kg; 1 mg/kg; 2 mg/kg
Administration:

p.o.
Result:

Reduced serum uric acid (SUA) levels to 267 μM, corresponding to a decrease ratio (DR) of 82.1%.
Reduced SUA levels to 371 μM, corresponding to a DR of 70.2%.
Reduced SUA levels to 582 μM, corresponding to a DR of 47.6%.
Reduced SUA levels to 273 μM, corresponding to a DR of 82.4%.

Chemical Information

Molecular Weight 653.63
Formel C₂₉H₂₅BrN₄O₃S₃
SMILES

O=C(CCCSC1=NC2=C(C(NC3=C4C(C=CC=C4)=C(C=C3)C5CC5)=N1)SC=C2)NS(C6=CC=C(C=C6)Br)(=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Yang Q, et al. Discovery of a Novel Thienopyrimidine Derivative as a Potent Dual URAT1/GLUT9 Inhibitor with Enhanced Urate-Lowering Efficacy, Superior Pharmacokinetics, and Favorable Safety Profile for Gout and Hyperuricemia. J Med Chem. Published online May 6, 2026. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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URAT1/GLUT9-IN-3

Alle GLUT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

URAT1/GLUT9-IN-3 Related Classifications

HY-183658 Related Classifications