2. Recombinant Proteins
  3. Immune Checkpoint Proteins
  4. Inhibitory Checkpoint Molecules
  5. BTLA

BTLA

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B and T cell lymphocyte attenuator (BTLA; CD272) is an inhibitory receptor that belongs to the B7-CD28 family. BTLA is structurally and functionally related to CTLA-4 and PD-1 and can be identified on most lymphocytes, such as T and B lymphocytes, macrophages, dendritic cells, and nature killer (NK) cells. The BTLA ligand, herpesvirus entry mediator (HVEM, also called TNFRSF14), is a member of the tumor necrosis factor receptor (TNFR) superfamily. Ligation of BTLA by HVEM induces tyrosine phosphorylation of ITIM in BTLA and subsequent recruitment of the protein tyrosine phosphatases SHP-1/SHP-2, and then exerts direct negative effects on the proliferation and activation of B and T cells. BTLA participates in numerous physiopathological processes, such as tumor, inflammatory diseases, autoimmune diseases, infectious diseases, and transplantation rejection.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P78078
    BTLA/CD272 Protein, Human (Biotinylated, HEK293, His-Avi)

    CD272; BTLA; BTLA1; FLJ16065; MGC129743

    		Human HEK293
    The BTLA/CD272 protein is expressed on lymphocytes and is a negative regulator of antigen receptor signaling. It interacts with the tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 to regulate immune responses and maintain lymphocyte homeostasis. BTLA/CD272 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived BTLA/CD272 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of BTLA/CD272 Protein, Human (Biotinylated, HEK293, His-Avi) is 120 a.a., with molecular weight of 38-50 kDa.
  • HY-P75466
    BTLA/CD272 Protein, Rat (HEK293, mFc)

    B- and T-lymphocyte attenuator; CD272; BTLA

    		Rat HEK293
    BTLA/CD272 protein inhibits antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. It regulates immune responses through cis and trans interactions with TNFRSF14. In cis, it maintains resting state in naive T cells, while in trans, it supports survival signals in effector T cells. BTLA/CD272 interacts with PTPN6/SHP-1, PTPN11/SHP-2, and TNFRSF14/HVEM. BTLA/CD272 Protein, Rat (HEK293, mFc) is the recombinant rat-derived BTLA/CD272 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of BTLA/CD272 Protein, Rat (HEK293, mFc) is 154 a.a., with molecular weight of ~55-77 kDa.
  • HY-P7678
    BTLA/CD272 Protein, Human (HEK293, His)

    rHuBTLA/CD272, His; B- and T-Lymphocyte Attenuator; CD272; BTLA

    		Human HEK293
    The BTLA/CD272 protein is expressed on lymphocytes and is a negative regulator of antigen receptor signaling. It interacts with the tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 to regulate immune responses and maintain lymphocyte homeostasis. BTLA/CD272 Protein, Human (HEK293, His) is the recombinant human-derived BTLA/CD272 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of BTLA/CD272 Protein, Human (HEK293, His) is 168 a.a., with molecular weight of ~30.0 kDa.
  • HY-P72030
    BTLA/CD272 Protein, Human (HEK293, hFc-Myc)

    B- and T-lymphocyte-associated protein; CD272;

    		Human HEK293
    The BTLA/CD272 protein is expressed on lymphocytes and is a negative regulator of antigen receptor signaling. It interacts with the tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 to regulate immune responses and maintain lymphocyte homeostasis. BTLA/CD272 Protein, Human (HEK293, hFc-Myc) is the recombinant human-derived BTLA/CD272 protein, expressed by HEK293 , with C-hFc, C-Myc labeled tag. The total length of BTLA/CD272 Protein, Human (HEK293, hFc-Myc) is 120 a.a., with molecular weight of ~43.9 kDa.
  • HY-P72858
    BTLA/CD272 Protein, Human (104a.a, HEK293, Fc)

    B-and T-lymphocyte attenuator; CD272; BTLA

    		Human HEK293
    BTLA/CD272 Protein, expressed on lymphocytes, is a negative regulator of antigen receptor signaling. Interacting with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2, it modulates immune responses and maintains lymphocyte homeostasis. BTLA engages in cis and trans interactions with TNFRSF14; cis interactions regulate naive T cells, inhibiting trans interactions to maintain a resting state. During adaptive immune responses, predominant trans interactions provide survival signals to effector T cells. The intricate interplay highlights BTLA's multifaceted role in immune regulation. BTLA/CD272 Protein, Human (104a.a, HEK293, Fc) is the recombinant human-derived BTLA/CD272 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of BTLA/CD272 Protein, Human (104a.a, HEK293, Fc) is 104 a.a., with molecular weight of ~42.2 kDa.
  • HY-P75467
    BTLA/CD272 Protein, Mouse (HEK293, hFc)

    B- and T-lymphocyte attenuator; CD272; BTLA

    		Mouse HEK293
    The BTLA/CD272 protein is expressed on lymphocytes and is a negative regulator of antigen receptor signaling. It interacts with the tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 to regulate immune responses and maintain lymphocyte homeostasis. BTLA/CD272 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived BTLA/CD272 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of BTLA/CD272 Protein, Mouse (HEK293, hFc) is 147 a.a., with molecular weight of 57-62 kDa.
  • HY-P78394
    BTLA/CD272 Protein, Human (HEK293, His-Avi)

    CD272; BTLA; BTLA1; FLJ16065; MGC129743

    		Human HEK293
    The BTLA/CD272 protein is expressed on lymphocytes and is a negative regulator of antigen receptor signaling. It interacts with the tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 to regulate immune responses and maintain lymphocyte homeostasis. BTLA/CD272 Protein, Human (HEK293, His-Avi) is the recombinant human-derived BTLA/CD272 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of BTLA/CD272 Protein, Human (HEK293, His-Avi) is 120 a.a., with molecular weight of 35-45 kDa.
  • HY-P76751
    BTLA/CD272 Protein, Rhesus Macaque (HEK293, Fc)

    B- and T-lymphocyte attenuator; CD272; BTLA

    		Rhesus Macaque HEK293
    BTLA/CD272 Protein, expressed on lymphocytes, is a negative regulator of antigen receptor signaling. Interacting with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2, it modulates immune responses and maintains lymphocyte homeostasis. BTLA engages in cis and trans interactions with TNFRSF14; cis interactions regulate naive T cells, inhibiting trans interactions to maintain a resting state. During adaptive immune responses, predominant trans interactions provide survival signals to effector T cells. The intricate interplay highlights BTLA's multifaceted role in immune regulation. BTLA/CD272 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived BTLA/CD272 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of BTLA/CD272 Protein, Rhesus Macaque (HEK293, Fc) is 125 a.a., with molecular weight of ~41.4 KDa.
  • HY-P7679
    BTLA/CD272 Protein, Human (168a.a, HEK293, Fc)

    rHuBTLA/CD272, C-Fc; B- and T-Lymphocyte Attenuator; CD272; BTLA

    		Human HEK293
    BTLA/CD272 Protein, Human (168a.a, HEK293, Fc) is a recombinant human BTLA/CD272 produced in HEK293 cells, with an Fc fragment at the C-terminus. BTLA/CD272 is a suppressor molecule belonging to the immunoglobulin superfamily which is involved in the inhibition of immune responses.
  • HY-P78246
    BTLA/CD272 Protein, Mouse (HEK293, His)

    CD272; BTLA; BTLA1; FLJ16065; MGC129743

    		Mouse HEK293
    The BTLA/CD272 protein is expressed on lymphocytes and is a negative regulator of antigen receptor signaling. It interacts with the tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 to regulate immune responses and maintain lymphocyte homeostasis. BTLA/CD272 Protein, Mouse (HEK293, His) is the recombinant mouse-derived BTLA/CD272 protein, expressed by HEK293 , with C-His labeled tag. The total length of BTLA/CD272 Protein, Mouse (HEK293, His) is 147 a.a., with molecular weight of 35-50 kDa.
  • HY-P76752
    BTLA/CD272 Protein, Rhesus Macaque (HEK293, His)

    B- and T-lymphocyte attenuator; CD272; BTLA

    		Rhesus Macaque HEK293
    BTLA/CD272 Protein, expressed on lymphocytes, is a negative regulator of antigen receptor signaling. Interacting with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2, it modulates immune responses and maintains lymphocyte homeostasis. BTLA engages in cis and trans interactions with TNFRSF14; cis interactions regulate naive T cells, inhibiting trans interactions to maintain a resting state. During adaptive immune responses, predominant trans interactions provide survival signals to effector T cells. The intricate interplay highlights BTLA's multifaceted role in immune regulation. BTLA/CD272 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived BTLA/CD272 protein, expressed by HEK293 , with C-His labeled tag. The total length of BTLA/CD272 Protein, Rhesus Macaque (HEK293, His) is 125 a.a., with molecular weight of ~19.3 KDa.
Cat. No. Product Name Effect Purity