1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. IGF family

The Insulin-Like Growth Factor (IGF) family consists of two ligands, (IGF-I and IGF-II), two cell-surface receptors (IGF-IR and IGF-IIR), at least six high affinity binding proteins (IGFBPs 1-6), and a group of low-affinity IGFBP-related proteins (IGFBP-rPs). Members of IGF family form a network of interactions both among themselves and with other growth factors families and their signalling pathways. IGFs play an important role in regulating cell proliferation, differentiation, apoptosis, and transformation.

Cat. No. Product Name / Synonyms Species Source
  • HY-P7018
    IGF-I/IGF-1 Protein, Human (70a.a)

    rHuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I

    Human E. coli
    IGF-I/IGF-1 Protein, Human (70a.a) is a mitogenic cytokine, binds to IGF type 1 receptor, and modulates growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone; IGF-I/IGF-1 Protein also mediates neuroprotective mechanism.
  • HY-P70783
    LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R)

    Long R3 IGF-I; Insulin-like growth factor I; MGF; Somatomedin-C; IBP1

    Human E. coli
    The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R) is the recombinant human-derived LR3 IGF-I/IGF-1 protein, expressed by E. coli , with tag free. and E51R, , , , mutation. The total length of LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R) is 70 a.a., with molecular weight of ~11.0 kDa.
  • HY-P70787
    IGF-I/IGF-1 Protein, Human (67a.a)

    Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1

    Human E. coli
    The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. IGF-I/IGF-1 Protein, Human (67a.a) is the recombinant human-derived IGF-I/IGF-1 protein, expressed by E. coli , with tag free. The total length of IGF-I/IGF-1 Protein, Human (67a.a) is 67 a.a., with molecular weight of ~9.0 kDa.
  • HY-P7368
    IGFBP-2 Protein, Human (HEK293, His)

    rHuIGF-BP-2, His; IBP-2; IGFBP-2; BP2

    Human HEK293
    IGFBP2 Protein, Human (HEK293, His) is a member of the family of high-affinity binding proteins (IGFBP1-6) and appears to play a governing role in Insulin-like Growth Factor (IGF) regulation in the central nervous system.
  • HY-P70783G
    GMP LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R)

    Long R3 IGF-I; Insulin-like growth factor I; MGF; Somatomedin-C; IBP1

    Human E. coli
    The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. GMP LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R) is the recombinant human-derived LR3 IGF-I/IGF-1 protein, expressed by E. coli , with tag free. The total length of GMP LR3 IGF-I/IGF-1 Protein, Human (83a.a, E51R) is 70 a.a., with molecular weight of ~11 kDa.
  • HY-P73136
    IGF-I/IGF-1 Protein, Human (HEK293, hFc)

    Insulin-like growth factor I; IGF-I; MGF; Somatomedin-C; IBP1

    Human HEK293
    The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. IGF-I/IGF-1 Protein, Human (HEK293, hFc) is the recombinant human-derived IGF-I/IGF-1 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of IGF-I/IGF-1 Protein, Human (HEK293, hFc) is 70 a.a., with molecular weight of 35-40 kDa.
  • HY-P73141
    IGFBP-6 Protein, Human (HEK293, His)

    Insulin-like growth factor-binding protein 6; IBP-6; IGFBP-6; IBP6

    Human HEK293
    IGFBP-6 protein is an important IGFBP member that regulates insulin-like growth factor (IGF) by changing its interaction with cell surface receptors, thereby affecting IGF-induced growth responses. In addition to regulating IGF signaling, IGFBP-6 also activates the MAPK pathway and induces cell migration. IGFBP-6 Protein, Human (HEK293, His) is the recombinant human-derived IGFBP-6 protein, expressed by HEK293 , with C-His labeled tag. The total length of IGFBP-6 Protein, Human (HEK293, His) is 240 a.a., with molecular weight of ~36 kDa.
  • HY-P74442
    IGF-I R Protein, Human (HEK293, His, solution)

    Insulin-like growth factor 1 receptor; IGF-I receptor; CD221; IGF1R

    Human HEK293
    IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (HEK293, His, solution) is the recombinant human-derived IGF-I R protein, expressed by HEK293 , with C-His labeled tag. The total length of IGF-I R Protein, Human (HEK293, His, solution) is 902 a.a., with molecular weight of ~150 kDa.
  • HY-P78142
    IGF-I R Protein, Human (Biotinylated, HEK293, His-Avi)

    CD221; IGF1R; IGF-1R; IGF-I R; IGF-I receptor; IGFIR; IGFR; JTK13; MGC142170; MGC142172; MGC18216

    Human HEK293
    IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IGF-I R protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of IGF-I R Protein, Human (Biotinylated, HEK293, His-Avi) is 902 a.a., with molecular weight of 110-120 kDa (alpha subunit) & 52-55 kDa (beta subunit), respectively.
  • HY-P78458
    IGF-I R Protein, Human (HEK293, His-Avi)

    CD221; IGF1R; IGF-1R; IGF-I R; IGF-I receptor; IGFIR; IGFR; JTK13; MGC142170; MGC142172; MGC18216

    Human HEK293
    IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (HEK293, His-Avi) is the recombinant human-derived IGF-I R protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of IGF-I R Protein, Human (HEK293, His-Avi) is 902 a.a., with molecular weight of 110-130 kDa (alpha subunit) & 52-55 kDa (beta subunit), respectively.
  • HY-P700094AF
    Animal-Free IGF2 Protein, Human (His)

    Somatamedin A; IGF-II

    Human E. coli
    The IGF2 protein is an important member of the insulin-like growth factor family and plays an important role in mammalian growth, fetoplacental development, and adult glucose metabolism. Regulated by placental prolactin, affecting tissue differentiation. Animal-Free IGF2 Protein, Human (His) is the recombinant human-derived animal-FreeIGF2 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free IGF2 Protein, Human (His) is 67 a.a., with molecular weight of ~8.28 kDa.
  • HY-P70788
    IGF-I/IGF-1 Protein, Human (G49-A118)

    Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1

    Human E. coli
    The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. IGF-I/IGF-1 Protein, Human (G49-A118) is the recombinant human-derived IGF-I/IGF-1 protein, expressed by E. coli , with tag free. The total length of IGF-I/IGF-1 Protein, Human (G49-A118) is 70 a.a., with molecular weight of ~9.0 kDa.
  • HY-P72606
    IGF-I R Protein, Human (HEK293, His)

    Insulin-like growth factor 1 receptor; IGF-I receptor; IGF1R; CD221

    Human HEK293
    IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (HEK293, His) is the recombinant human-derived IGF-I R protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IGF-I R Protein, Human (HEK293, His) is 902 a.a., with molecular weight of 100-130 & 54 kDa, respectively.
  • HY-P7369
    IGFBP-4 Protein, Human (HEK293, C-His)

    rHuIGF-BP-4, His; IBP-4; IGFBP-4; BP4

    Human HEK293
    IGFBP-4 Protein, Human is a member of the insulin-like growth factor-binding protein (IGFBP) family, binds to insulin-like growth factors, mediates IGF-independent biologic activities.
  • HY-P73142
    IGFBP-7 Protein, Human (HEK293, Fc)

    Insulin-like growth factor-binding protein 7; IGFBP7; TAF; MAC25; PSF

    Human HEK293
    IGFBP-7 Protein, with relatively low IGF-I and IGF-II affinity, stimulates prostacyclin (PGI2) production and enhances cell adhesion. The significance of its interaction with VPS24/CHMP3 remains uncertain and warrants further investigation. IGFBP-7 Protein, Human (HEK293, Fc) is the recombinant human-derived IGFBP-7 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IGFBP-7 Protein, Human (HEK293, Fc) is 256 a.a., with molecular weight of 60-70 kDa.
  • HY-P74845
    IGFBP-4 Protein, Mouse (HEK293, His)

    BP-4; HT29-IGFBP; IBP4; Insulin-like growth factor-binding protein 4

    Mouse HEK293
    IGFBP-4 protein modulates IGFs' activity and can either inhibit or stimulate their growth-promoting effects. It alters the interaction between IGFs and their receptors, with a preference for binding to IGF2. This highlights the nuanced role of IGFBP-4 in fine-tuning IGF-mediated cellular responses. IGFBP-4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IGFBP-4 protein, expressed by HEK293 , with C-His labeled tag. The total length of IGFBP-4 Protein, Mouse (HEK293, His) is 254 a.a., with molecular weight of ~38 kDa.
  • HY-P78104
    CCN2/CTGF Protein, Human (Biotinylated, HEK293, His-Avi)

    IGFBP8; IBP-8; CCN2; NOV2; HCS24; CTGF; CTGRP; Fisp12; MGC102839

    Human HEK293
    CCN2/CTGF (Connective Tissue Growth Factor) is a protein produced primarily by endothelial cells in blood vessels. It plays an important role in various cellular processes. CCN2/CTGF Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CCN2/CTGF protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CCN2/CTGF Protein, Human (Biotinylated, HEK293, His-Avi) is 323 a.a., with molecular weight of 43-55 kDa.
  • HY-P78713
    CCN2/CTGF Protein, Rhesus macaque (HEK293, His)

    CCN2; NOV2; HCS24; IGFBP8; IBP-8; IGFBP-8; IGF-binding protein 8

    Rhesus Macaque HEK293
    CCN2 is a mitogen secreted by vascular endothelial cells and a mechanosensor of mesenchymal cell differentiation that secretes stromal cell proteins. CCN2 can sense appropriate mechanical stress and downregulate its expression accordingly. CCN2 is a classic epithelial-to-mesenchymal transition (EMT) and fibrosis marker. CCN2/CTGF Protein, Rhesus macaque (HEK293, His) is the recombinant Rhesus Macaque-derived CCN2/CTGF protein, expressed by HEK293, with C-His labeled tag. The total length of CCN2/CTGF Protein, Rhesus macaque (HEK293, His) is 323 a.a., with molecular weight of 39-45 kDa.
  • HY-P78723
    IGF-I R Protein, Mouse (HEK293, His)

    IGF1R; IGFR; JTK13; CD221; MGC142170; MGC142172; MGC18216

    Mouse HEK293
    The IGF-I R protein, a receptor tyrosine kinase, mediates insulin-like growth factor 1 (IGF1) actions, with high affinity for IGF1. Upon ligand binding, IGF1R activates, leading to autophosphorylation and tyrosine phosphorylation of substrates, including IRS1/2, Shc, and 14-3-3 proteins. Phosphorylation initiates PI3K-AKT/PKB and Ras-MAPK pathways, regulating proliferation and apoptosis. IGF1R signals through JAK/STAT, activating STAT3, contributing to its transforming activity. It also activates JNK and inhibits JNK activation, forming a hybrid receptor with INSR to bind IGF1. IGF-I R Protein, Mouse (HEK293, His) is the recombinant mouse-derived IGF-I R protein, expressed by HEK293, with C-His labeled tag. The total length of IGF-I R Protein, Mouse (HEK293, His) is 906 a.a., with molecular weight of 110-140 & 50-65 kDa, respectively.
  • HY-P700093AF
    Animal-Free IGF-I/IGF-1 Protein, Human (His)

    Somatamedin C; IGF-IA; Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1

    Human E. coli
    The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. Animal-Free IGF-I/IGF-1 Protein, Human (His) is the recombinant human-derived animal-FreeIGF-I/IGF-1 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IGF-I/IGF-1 Protein, Human (His) is 70 a.a., with molecular weight of ~8.59 kDa.
Cat. No. Product Name Effect Purity