1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin

Sirtuin

Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaeaand eukaryotes. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.

Sirtuin Isoform Specific Products:

  • Sirtuin

  • SIRT1

  • SIRT2

  • SIRT3

  • SIRT6

Sirtuin Related Products (28):

Cat. No. Product Name Effect Purity
  • HY-15452
    EX-527 Inhibitor 99.82%
    EX-527 is a potent and selective SIRT1 inhibitor with IC50 of 98 nM.
  • HY-15145
    SRT 1720 Hydrochloride Activator 99.92%
    SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities on SIRT2 and SIRT3 with EC1.5s of 37 μM and 300 μM, respectively.
  • HY-B0150
    Nicotinamide Inhibitor >98.0%
    Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
  • HY-13515
    Sirtinol Inhibitor >98.0%
    Sirtinol is a sirtuin inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively.
  • HY-108331
    3-TYP 99.87%
    3-TYP is a selective SIRT3 inhibitor, with an IC50 of 16 nM, more potent over SIRT1 (IC50=88 nM), SIRT2 (IC50=92 nM).
  • HY-112634
    SIRT5 inhibitor Inhibitor 99.36%
    SIRT5 inhibitor is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM.
  • HY-112587
    MC3482 Inhibitor
    MC3482 is a specific sirtuin5 (SIRT5) inhibitor.
  • HY-16615
    SIRT-IN-1 Inhibitor
    SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively.
  • HY-15262
    SRT 2104 Activator 98.51%
    SRT 2104 is a brain-permeable activator of SIRT1, used for the research of type 2 diabetes mellitus and Huntington's disease.
  • HY-N0182
    Fisetin Activator >98.0%
    Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
  • HY-101278
    Thiomyristoyl Inhibitor 98.84%
    Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM.
  • HY-107454
    OSS_128167 Inhibitor 98.22%
    OSS_128167 is a selective SIRT6 inhibitor with IC50s of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.
  • HY-100732
    Cambinol Inhibitor 98.57%
    Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 and 59 μM, respectively.
  • HY-15510B
    Tenovin 6 Hydrochloride Inhibitor >98.0%
    Tenovin-6 Hydrochloride is a water soluble inhibitor of SIRT1 and SIRT2, slightly inhibits HDAC8, and is also a potent activator of p53, with IC50s of 21 μM, 10 μM, 67 μM for SirT1, SirT2, and SirT3, respectively.
  • HY-104073
    CAY10602 Activator 98.56%
    CAY10602 is a SIRT1 activator.
  • HY-13423
    Tenovin-1 Inhibitor 99.39%
    Tenovin-1 is an inhibitor of sirtuin 1 and sirtuin 2, an activator of p53 and may have potential in the management of cancer.
  • HY-15869
    Inauhzin Inhibitor 98.91%
    Inauhzin is a dual SirT1/IMPDH2 inhibitor, and acts as an activator p53, used in the research of cancer.
  • HY-16691
    AK-7 Inhibitor 99.59%
    AK-7 is a selective cell- and brain-permeable SIRT2 inhibitor, with an IC50 of 15.5 μM.
  • HY-15510
    Tenovin-6 Inhibitor 98.24%
    Tenovin-6 is a water soluble inhibitor of SIRT1 and SIRT2, slightly inhibits HDAC8, and is also a potent activator of p53, with IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively.
  • HY-101073
    Salermide Inhibitor >98.0%
    Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death.
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.