Signaling Pathway

Sirtuin

Sirtuin

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Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaeaand eukaryotes. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.

Sirtuin Inhibitors & Modulators (14)

Product Name Catalog No. Brief Description
AK-7

HY-16691

AK-7 is a selective and brain-permeable SIRT2 inhibitor; is neuroprotective in Huntington disease mouse models.

EX-527

HY-15452

EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits >200-fold selectivity against SIRT2 and SIRT3.

EX-527 R-enantiomer

HY-15452B

EX-527 R-enantiomer is a negative control of the active form EX-527 S-enantiomer(Speculated for reference); IC50 > 100 uM, e1/e2 can be found in the reference paper.

EX-527 S-enantiomer

HY-15452A

EX-527 S-enantiomer is a potent and selective SIRT1 inhibitor with IC50 of 123 nM; no inhibition on SIRT3 and SIRT3.

Inauhzin

HY-15869

Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell).

Quercetin

HY-18085

Quercetin is a flavonoid with anticancer activity; mitochondrial ATPase and phosphodiesterase inhibitor and Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity.

Sirtinol

HY-13515

Sirtinol is a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells.

Sirtuin modulator 1

HY-19758A

Sirtuin modulator 1 is a sirtuin modulator extracted from patent WO/2010071853 A1, compound 570, with EC1.5 <1 uM.

SRT 1720

HY-10532

SRT1720 is a selective activator of human SIRT1 (EC1.5 = 0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5 = 37 μM;SIRT3: EC1.5 > 300 μM).

SRT 1720 Hydrochloride

HY-15145

SRT1720 hydrochloride is a selective activator of human SIRT1 (EC1.5 = 0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5 = 37 μM;SIRT3: EC1.5 > 300 μM).

SRT 2104

HY-15262

6-phenylimidazo[2,1-b]thiazole derivatives; SRT 2104.

Tenovin 6 Hydrochloride

HY-15510B

Tenovin-6 is the water soluble analog of Tenovin-1 (HY-13423) and acts as a potent SIRT1 (IC50=21 uM) and SIRT2 (IC50= 10 uM) inhibitor as well as p53 activator.

Tenovin-1

HY-13423

Tenovin-1 is a inhibitor of SIRT1 and SIRT2; activator of p21 and p53.

Tenovin-6

HY-15510

Tenovin-6 is the water soluble analog of Tenovin-1 (HY-13423) and acts as a potent SIRT1 (IC50=21 uM) and SIRT2 (IC50= 10 uM) inhibitor as well as p53 activator.