1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin

Sirtuin

Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaeaand eukaryotes. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.

Sirtuin Isoform Specific Products:

  • Sirtuin

  • SIRT1

  • SIRT2

  • SIRT3

  • SIRT6

Sirtuin Related Products (35):

Cat. No. Product Name Effect Purity
  • HY-15452
    Selisistat Inhibitor 99.82%
    Selisistat (EX-527) is a potent and selective SIRT1 inhibitor with IC50 of 98 nM.
  • HY-B0150
    Nicotinamide Inhibitor >98.0%
    Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
  • HY-15145
    SRT 1720 Hydrochloride Activator 99.92%
    SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities on SIRT2 and SIRT3 with EC1.5s of 37 μM and 300 μM, respectively.
  • HY-108331
    3-TYP Inhibitor 99.87%
    3-TYP is a selective SIRT3 inhibitor, with an IC50 of 16 nM, more potent over SIRT1 (IC50=88 nM), SIRT2 (IC50=92 nM).
  • HY-13515
    Sirtinol Inhibitor >98.0%
    Sirtinol is a sirtuin inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively.
  • HY-119376
    MDL-800 Activator 98.53%
    MDL-800 is an allosteric and selective SIRT6 activator. MDL-800 increases SIRT6 deacetylation activity with an EC50 of 10.3 µM.
  • HY-115453
    UBCS039 Activator
    UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM.
  • HY-112427
    Sirt2-IN-1 Inhibitor
    Sirt2-IN-1 (Compound 9) is a sirtuin 2 (Sirt2) inhibitor with an IC50 of 163 nM.
  • HY-N0182
    Fisetin Activator 98.02%
    Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
  • HY-15262
    SRT 2104 Activator 98.87%
    SRT 2104 is a brain-permeable activator of SIRT1, used for the research of type 2 diabetes mellitus and Huntington's disease.
  • HY-107454
    OSS_128167 Inhibitor 98.22%
    OSS_128167 is a selective SIRT6 inhibitor with IC50s of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.
  • HY-101278
    Thiomyristoyl Inhibitor 98.84%
    Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM.
  • HY-104073
    CAY10602 Activator 98.56%
    CAY10602 is a SIRT1 activator.
  • HY-100732
    Cambinol Inhibitor 98.57%
    Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 and 59 μM, respectively.
  • HY-15510
    Tenovin-6 Inhibitor 98.24%
    Tenovin-6 is a water soluble inhibitor of SIRT1 and SIRT2, slightly inhibits HDAC8, and is also a potent activator of p53, with IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively.
  • HY-13423
    Tenovin-1 Inhibitor 99.39%
    Tenovin-1 is an inhibitor of sirtuin 1 and sirtuin 2, an activator of p53 and may have potential in the management of cancer.
  • HY-16691
    AK-7 Inhibitor 99.59%
    AK-7 is a selective cell- and brain-permeable SIRT2 inhibitor, with an IC50 of 15.5 μM.
  • HY-15510B
    Tenovin 6 Hydrochloride Inhibitor >98.0%
    Tenovin-6 Hydrochloride is a water soluble inhibitor of SIRT1 and SIRT2, slightly inhibits HDAC8, and is also a potent activator of p53, with IC50s of 21 μM, 10 μM, 67 μM for SirT1, SirT2, and SirT3, respectively.
  • HY-101073
    Salermide Inhibitor >98.0%
    Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death.
  • HY-15869
    Inauhzin Inhibitor 98.91%
    Inauhzin is a dual SirT1/IMPDH2 inhibitor, and acts as an activator p53, used in the research of cancer.
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.