1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin

Sirtuin

Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaeaand eukaryotes. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.

Sirtuin Related Products (18):

Cat. No. Product Name Effect Purity
  • HY-15452
    EX-527 Inhibitor 99.79%
    EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits >200-fold selectivity against SIRT2 and SIRT3.
  • HY-18085
    Quercetin Activator 98.21%
    Quercetin is a flavonoid with anticancer activity; mitochondrial ATPase and phosphodiesterase inhibitor and Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity.
  • HY-15145
    SRT 1720 Hydrochloride Activator 98.79%
    SRT1720 hydrochloride is a selective activator of human SIRT1 (EC1.5 = 0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5 = 37 μM; SIRT3: EC1.5 > 300 μM).
  • HY-15262
    SRT 2104 Activator 99.60%
    SRT 2104 is a small molecule Sirtuin 1 activator.
  • HY-13515
    Sirtinol Inhibitor >98.0%
    Sirtinol is a sirtuin inhibitor; inhibit the growth of MCF-7 cells with an IC50 of 48.6 μM at 24 h.
  • HY-101278
    Thiomyristoyl Inhibitor 98.84%
    Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM.
  • HY-101465
    AK-1 Inhibitor >98.0%
    AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor.
  • HY-101073
    Salermide Inhibitor >98.00%
    Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death.
  • HY-15510B
    Tenovin 6 Hydrochloride Inhibitor
    Tenovin-6 Hydrochloride is a water soluble inhibitor of SIRT1 and SIRT2, slightly inhibits HDAC8, and is also a potent activator of p53, with IC50s of 21 μM, 10 μM, 67 μM and 90 μM for SirT1 peptide deacetylase, SirT2, SirT3, and HDAC8, respectively.
  • HY-13423
    Tenovin-1 Inhibitor 99.55%
    Tenovin-1 is a inhibitor of SIRT1 and SIRT2; activator of p21 and p53.
  • HY-15869
    Inauhzin Inhibitor 98.91%
    Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell).
  • HY-16691
    AK-7 Inhibitor 99.59%
    AK-7 is a selective and brain-permeable SIRT2 inhibitor; is neuroprotective in Huntington disease mouse models.
  • HY-19758A
    Sirtuin modulator 1 Modulator
    Sirtuin modulator 1 is a sirtuin modulator extracted from patent WO/2010071853 A1, compound 570, with EC1.5 <1 uM.
  • HY-15452A
    EX-527 S-enantiomer Inhibitor 98.29%
    EX-527 S-enantiomer is a potent and selective SIRT1 inhibitor with IC50 of 123 nM; no inhibition on SIRT3 and SIRT3.
  • HY-10532
    SRT 1720 Activator
    SRT1720 is a selective activator of human SIRT1 (EC1.5 = 0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5 = 37 μM;SIRT3: EC1.5 > 300 μM).
  • HY-15452B
    EX-527 R-enantiomer
    EX-527 R-enantiomer is a negative control of the active form EX-527 S-enantiomer(Speculated for reference); IC50 > 100 uM, e1/e2 can be found in the reference paper.
  • HY-15510
    Tenovin-6 Inhibitor
    Tenovin-6 is a water soluble inhibitor of SIRT1 and SIRT2, slightly inhibits HDAC8, and is also a potent activator of p53, with IC50s of 21 μM, 10 μM, 67 μM and 90 μM for SirT1 peptide deacetylase, SirT2, SirT3, and HDAC8, respectively.
  • HY-N0785
    Ginkgolide C Activator
    Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.