500271-63-6
Chemical Structure
2-APQC
- CAS No.: 500271-63-6
- Formula:C23H24FN5O
- Molecular Weight:405.47
InChIKey: FYNPHMNXVLLDAS-UHFFFAOYSA-N
SMILES: CCCCCNC(C1=C(N(C2=NC3=C(N=C21)C=CC=C3)CC4=CC=C(C=C4)F)N)=O
Biological Activity: 2-APQC is an orally active and selective agonist of Sirtuin-3 (SIRT3) (Kd=2.756 μM), antagonizes Isoproterenol/ISO (HY-B0468)-induced cytotoxicity. 2-APQC activates the SIRT3-PYCR1 axis to enhance mitochondrial proline metabolism and inhibit the ROS-p38MAPK pathway by inhibiting signaling pathways such as mTOR-p70S6K, JNK, and TGF-β/Smad3. 2-APQC also activates the AMPK-Parkin axis to alleviate myocardial hypertrophy and fibrosis and protect cardiac function. 2-APQC can be used in the study of heart failure[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
2-APQC | 99.70% | 2-APQC is an orally active and selective agonist of Sirtuin-3 (SIRT3) (Kd=2.756 μM), antagonizes Isoproterenol/ISO (HY-B0468)-induced cytotoxicity. 2-APQC activates the SIRT3-PYCR1 axis to enhance mitochondrial proline metabolism and inhibit the ROS-p38MAPK pathway by inhibiting signaling pathways such as mTOR-p70S6K, JNK, and TGF-β/Smad3. 2-APQC also activates the AMPK-Parkin axis to alleviate myocardial hypertrophy and fibrosis and protect cardiac function. 2-APQC can be used in the study of heart failure. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.76
HY-173572SKLB-11A -
Similarity Score 0.67
HY-175256RSK2-IN-5 -
Similarity Score 0.60
HY-111317SIRT1 activator 3 -
Similarity Score 0.60
HY-128311GRK6-IN-3 -
Similarity Score 0.54
HY-156176TLR7 agonist 15 -
Similarity Score 0.54
HY-103698ATLR7/8 agonist 1 dihydrochloride -
Similarity Score 0.53
HY-103698TLR7/8 agonist 1 -
Similarity Score 0.53
HY-158694TLR7 agonist 20 -
Similarity Score 0.53
HY-128231GRK6-IN-4 -
Explore the MedChemAI to find more analogs
