2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Hemoglobin

Hemoglobin

Hemoglobin

Hemoglobin is an iron-containing protein responsible for transporting oxygen and carbon dioxide. Hemoglobin in the blood transports oxygen from the respiratory organs (lungs or gills) to other tissues of the body, where it releases oxygen to enable aerobic respiration, thus powering the animal's metabolism. In addition, hemoglobin has the function of buffering the pH of the blood. When acidic or alkaline substances increase in the blood, hemoglobin can maintain the relative stability of the blood pH by binding to or releasing hydrogen ions, ensuring the normal activity of various enzymes in the body. Abnormalities in the structure or function of hemoglobin are related to blood diseases such as sickle cell anemia[1].

Hemoglobin Related Products (9):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-18681
    Voxelotor
    		Inhibitor 99.99%
    Voxelotor (GBT 440) is a potent inhibitor of haemoglobin S (HbS) polymerization. Voxelotor has the potential for sickle cell disease (SCD) treatment.
    Voxelotor
  • HY-148788
    Osivelotor
    		Inhibitor 98.10%
    Osivelotor is an orally effective small molecule. Osivelotor is an allosteric regulator of deoxyhemoglobin S (HbS). Osivelotor increases the affinity of HbS to oxygen, inhibits HbS polymerization, and thus prevents erythrocyte sickling in the blood. Osivelotor can be used for research of sickle cell disease (SCD) .
    Osivelotor
  • HY-172371
    Hypoxystat
    		99.28%
    Hypoxystat is an orally active hypoxia mimetic. HypoxyStat increases Hemoglobin’s oxygen affinity, limiting oxygen offloading to the tissues and inducing local tissue hypoxia. Hypoxystat reduces Iba1+ cells. HypoxyStat causes systemic hypoxia. Hypoxystat effectively rescues hyperglycemia in mouse models of type 1 and type 2 diabetes. HypoxyStat not only extends lifespan but also rescues key neuropathological and behavioral deficits in the premier mouse model of Leigh syndrome.
    Hypoxystat
  • HY-13619
    Efaproxiral
    		Modulator 99.94%
    Efaproxiral (RSR13) is a haemoglobin (Hb) synthetic allosteric modifier. Efaproxiral decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy .
    Efaproxiral
  • HY-13619A
    Efaproxiral sodium
    		Modulator 99.72%
    Efaproxiral (RSR13) sodium is a haemoglobin (Hb) synthetic allosteric modifier. Efaproxiral sodium decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy .
    Efaproxiral sodium
  • HY-W128159
    N-Acetyl-2-pyrrolidone
    N-Acetyl-2-pyrrolidone (No.20) is an N-acetylated amide. N-Acetyl-2-pyrrolidone can induce the differentiation of mouse erythroleukemia cells and has the activity of stimulating proliferation. N-Acetyl-2-pyrrolidone can be used in the research of leukemia differentiation therapy.
    N-Acetyl-2-pyrrolidone
  • HY-106509
    Velaresol
    		99.59%
    Velaresol (BW 12C) is a potent left-shifting anti-sickling compound in vitro. Sickle cell disease is an inherited disorder of the hemoglobin molecule. When hemoglobin molecules are exposed to a variety of environments, the red blood cell hemoglobin polymerizes, twists, and morphs into a sickle shape.
    Velaresol
  • HY-100826
    TN1
    TN1 is a potent fetal hemoglobin (HbF) inducer.
    TN1
  • HY-W175543
    Methoxyurea
    		Substrate
    Methoxyurea (Compound 3) is a potential regulator of nitric oxide (NO) donors that acts on hemoglobins such as oxy-hemoglobin (OxyHb) and met-hemoglobin (MetHb). Methoxyurea is promising for research of sickle cell disease (SCD).
    Methoxyurea