77858-21-0
77858-21-0
Chemical Structure
Velaresol
Synonym(s): BW 12C; 12C79; BW 12C79
- CAS. Nr.: 77858-21-0
- Formula:C12H14O5
- Molecular Weight:238.24
IUPAC Name: 5-(2-formyl-3-hydroxyphenoxy)pentanoic acid
InChIKey: NSUDGNLOXMLAEB-UHFFFAOYSA-N
SMILES: OC(CCCCOC1=C(C(O)=CC=C1)C=O)=O
Biological Activity: Velaresol (BW 12C) is a small molecule oxyhemoglobin stabilizer. Velaresol stabilizes hemoglobin’s oxy-conformation, shifts oxygen dissociation curves left, induces tumor hypoxia, alters radiosensitivity, protects normal tissues from radiation damage, and reduces sickled cell counts. Velaresol can be used for the research of cancer and sickle cell disease[1][2][3][4][5][6].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Velaresol | 99.59% | Velaresol (BW 12C) is a small molecule oxyhemoglobin stabilizer. Velaresol stabilizes hemoglobin’s oxy-conformation, shifts oxygen dissociation curves left, induces tumor hypoxia, alters radiosensitivity, protects normal tissues from radiation damage, and reduces sickled cell counts. Velaresol can be used for the research of cancer and sickle cell disease. | ||||||||||||||||||||
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Velaresol (Standard) | ≥98% | Velaresol (Standard) is the analytical standard of Velaresol. This product is intended for research and analytical applications. Velaresol (BW 12C) is a small molecule oxyhemoglobin stabilizer. Velaresol stabilizes hemoglobin’s oxy-conformation, shifts oxygen dissociation curves left, induces tumor hypoxia, alters radiosensitivity, protects normal tissues from radiation damage, and reduces sickled cell counts. Velaresol can be used for the research of cancer and sickle cell disease. | ||||||||||||||||||||
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References
- [1]. Honess DJ, et al. Effect of the manipulation of oxyhemoglobin status by BW12C on tumor thermosensitivity and on blood flow in tumor and normal tissues in mice. Int J Radiat Oncol Biol Phys. 1989 May;16(5):1187-90. [Content Brief]
- [2]. Hendrikse A, et al. Effect of BW12C on Mouse Tumor Response to Radiation. Radiation Oncology Investigations 1995, 3 (4), 151-156.
- [3]. van den Aardweg GJ, et al. Modification of the radiation response of pig skin by manipulation of tissue oxygen tension using anesthetics and administration of BW12C. Int J Radiat Oncol Biol Phys. 1989 May;16(5):1191-4. [Content Brief]
- [4]. Gibson J S, et al. Effect of the Substituted Benzaldehyde 12C79 on Cl- -Dependent K+ Influx in Human Red Blood Cells. Pflugers Archiv European Journal of Physiology 1999, 437 (3), 498-500.
- [5]. Kenny MW, et al. Preservation of deformability (filterability) of sickle cells by BW12C during progressive deoxygenation. Br J Haematol. 1983 Nov;55(3):465-71. [Content Brief]
- [6]. Falk SJ, et al. BW12C perturbs normal and tumour tissue oxygenation and blood flow in man. Radiother Oncol. 1994 Sep;32(3):210-7. [Content Brief]
