1. PI3K/Akt/mTOR
  2. Akt

Akt

Akt (protein kinase B, PKB) is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration. Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes. Akt2 is an important signaling molecule in the Insulin signaling pathway. The role of Akt3 is less clear, though it appears to be predominantly expressed in the brain. Akt regulates cellular survival and metabolism by binding and regulating many downstream effectors, e.g. Nuclear Factor-κB, Bcl-2 family proteins and MDM2. Akt inhibitors may treat cancers such as neuroblastoma and infection such as HIV and HSV.

Akt Related Products (42):

Cat. No. Product Name Effect Purity
  • HY-10256
    SB 203580 Inhibitor
    SB 203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM.
  • HY-10358
    MK 2206 (dihydrochloride) Inhibitor
    MK 2206 is an orally active allosteric Akt inhibitor with IC50 of 5 nM/12 nM/65 nM for Akt1/2/3, respectively.
  • HY-10425
    A-443654 Inhibitor
    A-443654 is a potent small-molecule inhibitor of all three Akt serine/threonine kinases, with Ki of 160 pM for Akt1.
  • HY-10256A
    SB 203580 hydrochloride Inhibitor
    SB 203580 hydrochloride is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM.
  • HY-10249
    GSK-690693 Inhibitor
    GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2/13/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. 
  • HY-15431
    AZD5363 Inhibitor
    AZD5363 is a potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,2 and 3, respectively.
  • HY-15727
    Afuresertib Inhibitor
    Afuresertib is an orally available, ATP-competitive, pan-AKT inhibitor with Ki of 0.08, 2 and 2.6 nM against AKT1, AKT2 and AKT3, respectively.
  • HY-13685
    Miltefosine Inhibitor
    Miltefosine is a PI3K/Akt inhibitor, dramatically reduces HIV-1 production from long-living virus-infected macrophages.
  • HY-10355
    AKT inhibitor VIII Inhibitor
    AKT inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity with IC50s of 58 nM, 210 nM, and 2.12 μM, respectively.
  • HY-N0003
    Honokiol Inhibitor
    Honokiol is a hydroxylated biphenyl compound, which inhibits the activation of Akt and enhances the phosphorylation of ERK1/2.
  • HY-13425
    Deguelin Inhibitor
    Deguelin is a natural product isolated from plants in the Mundulea sericea family, and acts as an AKT inhibitor.
  • HY-50909
    Perifosine Inhibitor
    Perifosine is an oral Akt inhibitor. All cells are sensitive to the antiproliferative properties of Perifosine with an IC50 of ∼0.6-8.9 μM.
  • HY-15457
    Triciribine Inhibitor
    Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively.
  • HY-15186
    GDC-0068 Inhibitor
    GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA.
  • HY-15186A
    GDC-0068 dihydrochloride Inhibitor
    GDC-0068 dihydrochloride is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA.
  • HY-13254
    A-674563 Inhibitor
    A-674563 is a potent selective Akt1 inhibitor with an IC50 of 14 nM; also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
  • HY-12059
    AT7867 Inhibitor
    AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family.
  • HY-15965
    GSK2141795 Inhibitor
    GSK2141795 is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively.
  • HY-13260
    CCT128930 Inhibitor
    CCT128930 is a novel potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM; >28-fold selectivity for Akt2 than the closely related PKA kinase.
  • HY-10721
    AKT inhibitor Inhibitor
    AKT inhibitor is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50 = 0.5 nM) than PKA (IC50=450 nM).