Signaling Pathway

Akt

Akt

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Akt (protein kinase B, PKB) is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration. Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes. Akt2 is an important signaling molecule in the Insulin signaling pathway. The role of Akt3 is less clear, though it appears to be predominantly expressed in the brain. Akt regulates cellular survival and metabolism by binding and regulating many downstream effectors, e.g. Nuclear Factor-κB, Bcl-2 family proteins and MDM2. Akt inhibitors may treat cancers such as neuroblastoma and infection such as HIV and HSV.

Akt Inhibitors & Modulators (44)

Product Name Catalog No. Brief Description
1,3-Dicaffeoylquinic acid

HY-N1412

1,3-Dicaffeoylquinic acid is a caffeoylquinic acid derivative, and activates PI3K/Akt.

3CAI

HY-16666

3CAI is a potent allosteric and specific AKT inhibitor, which exerts efficacy in vitro and in vivo.

A-443654

HY-10425

A-443654 is a potent small-molecule inhibitor of all three Akt serine/threonine kinases, induces Akt Ser-473 phosphorylation in all human cancer cell lines tested, including PTEN- and TSC2-deficient lines.

A-674563

HY-13254

A-674563 is a potent selective Akt1 inhibitor with an IC50 of 14 nM; also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.

A-674563 hydrochloride

HY-13254A

A-674563 hydrochloride is a potent selective Akt1 inhibitor with an IC50 of 14 nM; also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.

Afuresertib

HY-15727

Afuresertib (GSK2110183) is a potent pan-AKT inhibitor that demonstrated synergy with bortezomib in preclinical models of multiple myeloma (MM).

Afuresertib hydrochloride

HY-15727A

Afuresertib Hcl (GSK2110183 Hcl) is a potent pan-AKT inhibitor that demonstrated synergy with bortezomib in preclinical models of multiple myeloma (MM).

AKT inhibitor

HY-10721

AKT inhibitor is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50 = 0.5 nM) than PKA (IC50=450 nM).

AKT inhibitor VIII

HY-10355

Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively).

AKT Kinase Inhibitor

HY-10249A

A Akt Kinase Inhibitor.

Akt1 and Akt2-IN-1

HY-50862

Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity.

ARQ-092

HY-19719

ARQ-092 is an Akt inhibitor extracted from patent US/20150299195A1, compound A.

Astragalus polysaccharide

HY-N0937

Astragalus polysaccharide, as one kind of biological macromolecule extracted from Astragalus, has antiviral activities.

AT13148

HY-16071

AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity; AKT, p70S6K, PKA, ROCK, and SGK inhibitor.

AT7867

HY-12059

AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family.

AT7867 dihydrochloride

HY-12059A

AT7867 Hcl is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family.

AZD5363

HY-15431

AZD5363, a novel pyrrolopyrimidine-derived compound, inhibits all AKT isoforms (IC50 <10 nM).

BAY1125976

HY-100018

BAY1125976 is a selective allosteric Akt1/2 inhibitor; inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively.

CCT128930

HY-13260

CCT128930 is a novel potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM; >28-fold selectivity for Akt2 than the closely related PKA kinase.

Deguelin

HY-13425

Deguelin, a naturally occurring rotenoid, is known to be an Akt inhibitor and to have an anti-tumor effect on several cancers; decrease levels of phosphorylated Akt.