1. PI3K/Akt/mTOR
  2. Akt

Akt

Akt (protein kinase B, PKB) is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration. Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes. Akt2 is an important signaling molecule in the Insulin signaling pathway. The role of Akt3 is less clear, though it appears to be predominantly expressed in the brain. Akt regulates cellular survival and metabolism by binding and regulating many downstream effectors, e.g. Nuclear Factor-κB, Bcl-2 family proteins and MDM2. Akt inhibitors may treat cancers such as neuroblastoma and infection such as HIV and HSV.

Akt Related Products (44):

Cat. No. Product Name Effect Purity
  • HY-10256
    SB 203580 Inhibitor 99.54%
    SB 203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM.
  • HY-10358
    MK 2206 dihydrochloride Inhibitor 99.27%
    MK 2206 is an orally active allosteric Akt inhibitor with IC50 of 5 nM/12 nM/65 nM for Akt1/2/3, respectively.
  • HY-18749
    SC79 Inhibitor >98.0%
    SC79 is a unique specific Akt activator that may be used to enhance Akt activity in various physiological and pathological conditions.
  • HY-10256A
    SB 203580 hydrochloride Inhibitor 99.71%
    SB 203580 hydrochloride is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM.
  • HY-15431
    AZD5363 Inhibitor
    AZD5363 is a potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,2 and 3, respectively.
  • HY-100018
    BAY1125976 Inhibitor 99.63%
    BAY1125976 is a selective allosteric Akt1/2 inhibitor; inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively.
  • HY-N1412
    1,3-Dicaffeoylquinic acid Activator 98.68%
    1,3-Dicaffeoylquinic acid is a caffeoylquinic acid derivative, and activates PI3K/Akt.
  • HY-N0751
    Scutellarin Inhibitor
    Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.
  • HY-10249
    GSK-690693 Inhibitor 98.17%
    GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2/13/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes.
  • HY-15727
    Afuresertib Inhibitor 98.91%
    Afuresertib is an orally available, ATP-competitive, pan-AKT inhibitor with Ki of 0.08, 2 and 2.6 nM against AKT1, AKT2 and AKT3, respectively.
  • HY-10425
    A-443654 Inhibitor 99.90%
    A-443654 is a potent small-molecule inhibitor of all three Akt serine/threonine kinases, with Ki of 160 pM for Akt1.
  • HY-N0003
    Honokiol Inhibitor 99.71%
    Honokiol(NSC-293100), a hydroxylated biphenyl compound isolated from the Chinese herb Magnolia officinalis, has been reported to have anticancer activities in a variety of cancer cell lines.
  • HY-10355
    AKT inhibitor VIII Inhibitor 99.14%
    AKT inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity with IC50s of 58 nM, 210 nM, and 2.12 μM, respectively.
  • HY-50909
    Perifosine Inhibitor >98.00%
    Perifosine is an oral Akt inhibitor.
  • HY-15457
    Triciribine Inhibitor 99.20%
    Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively.
  • HY-15615A
    TIC10 Inhibitor 99.79%
    TIC10 is a potent, orally active, and stable TRAIL inducer, also inhibits Akt and ERK activity.
  • HY-13685
    Miltefosine Inhibitor >98.0%
    Miltefosine is a PI3K/Akt inhibitor, dramatically reduces HIV-1 production from long-living virus-infected macrophages.
  • HY-15186
    GDC-0068 Inhibitor >98.0%
    GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA.
  • HY-15186A
    GDC-0068 dihydrochloride Inhibitor 98.93%
    GDC-0068 dihydrochloride is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA.
  • HY-13254
    A-674563 Inhibitor 99.86%
    A-674563 is a potent selective Akt1 inhibitor with Ki of 11 nM.