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AKT inhibitor VIII

(Synonyms: AKTi-1/2)
65 Cited Publications
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Based on 65 publication(s) in Google Scholar

AKT inhibitor VIII (AKTi-1/2) is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity with IC50s of 58 nM, 210 nM, and 2119 nM, respectively.

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  • Pureté: 98.36%
  • CAS No.: 612847-09-3
  • Formule: C34H29N7O
  • Masse moléculaire:551.64
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • AKT inhibitor VIII Chemical Structure
    AKT inhibitor VIII Chemical Structure
  • Experimental Validation Results for AKT inhibitor VIII
  • Experimental Validation Results for AKT inhibitor VIII
  • Experimental Validation Results for AKT inhibitor VIII
  • Experimental Validation Results for AKT inhibitor VIII
  • Experimental Validation Results for AKT inhibitor VIII
CAS No.: 612847-09-3
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  • AKT inhibitor VIII Chemical Structure
    AKT inhibitor VIII Chemical Structure
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    AKT inhibitor VIII purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2025 Aug;14(8):e70146. [Abstract]

    Customer Validation
     Effects of AKT inhibitor AKTi1/2 (0.5 µM) on S-EMs-induced VSMC proliferation and migration. S-EMs was administered 2 h after application of the inhibitors. VSMCs proliferation was evaluated by the percentage of EdU-positive cells. Ctrl, first column; AKTi1/2, fifth column.

  • 1/16

    AKT inhibitor VIII purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2025 Aug;14(8):e70146. [Abstract]

    Customer Validation
     Effects of AKT inhibitor AKTi1/2 (0.5 µM) on S-EMs-induced VSMC proliferation and migration. S-EMs was administered 2 h after application of the inhibitors. VSMCs migration was evaluated by the percentage of Boyden chamber assay. Ctrl, first column; AKTi1/2, fifth column.

  • 1/16

    AKT inhibitor VIII purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 24:e02763. [Abstract]

    Customer Validation
     Representative Western blot of TBC1D4 protein levels in skeletal muscle from WT and PAGR1f/f/Hsa-Cre mice following intraperitoneal injection of an AKT inhibitor (AKTi-1/2, 50mg/kg for 2 days) or saline in.

  • 1/16

    AKT inhibitor VIII purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Aug 18;11(8):644. [Abstract]

    Customer Validation
     AKT inhibitor VIII (AKTi VIII; 20-80 μM; 24 h). CCK-8 assay was used to evaluate the effects of different concentration of AKTi VIII on the viability of ovarian cancer cells at 24 h.

  • 1/16

    AKT inhibitor VIII purchased from MedChemExpress. Usage Cited in: Nat Commun. 2018 Nov 19;9(1):4874. [Abstract]

    Customer Validation
     The expression of p-S6ser235/236 in splenic NK cells from control versus Rictor∆/∆ mice after treatment with DMSO or 2 μM AKTi-1/2 for 6 h ex vivo.

  • AKT inhibitor VIII