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AKT inhibitor VIII

(Synonyms: AKTi-1/2)
65 Cited Publications
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Based on 65 publication(s) in Google Scholar

AKT inhibitor VIII (AKTi-1/2) is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity with IC50s of 58 nM, 210 nM, and 2119 nM, respectively.

For research use only. We do not sell to patients.

  • Purity: 98.36%
  • CAS No.: 612847-09-3
  • Formula: C34H29N7O
  • Molecular Weight:551.64
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • AKT inhibitor VIII Chemical Structure
    AKT inhibitor VIII Chemical Structure
  • Experimental Validation Results for AKT inhibitor VIII
  • Experimental Validation Results for AKT inhibitor VIII
  • Experimental Validation Results for AKT inhibitor VIII
  • Experimental Validation Results for AKT inhibitor VIII
  • Experimental Validation Results for AKT inhibitor VIII
CAS No.: 612847-09-3
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  • AKT inhibitor VIII Chemical Structure
    AKT inhibitor VIII Chemical Structure
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    AKT inhibitor VIII purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2025 Aug;14(8):e70146. [Abstract]

    Customer Validation
     Effects of AKT inhibitor AKTi1/2 (0.5 µM) on S-EMs-induced VSMC proliferation and migration. S-EMs was administered 2 h after application of the inhibitors. VSMCs proliferation was evaluated by the percentage of EdU-positive cells. Ctrl, first column; AKTi1/2, fifth column.

  • 1/16

    AKT inhibitor VIII purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2025 Aug;14(8):e70146. [Abstract]

    Customer Validation
     Effects of AKT inhibitor AKTi1/2 (0.5 µM) on S-EMs-induced VSMC proliferation and migration. S-EMs was administered 2 h after application of the inhibitors. VSMCs migration was evaluated by the percentage of Boyden chamber assay. Ctrl, first column; AKTi1/2, fifth column.

  • 1/16

    AKT inhibitor VIII purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 24:e02763. [Abstract]

    Customer Validation
     Representative Western blot of TBC1D4 protein levels in skeletal muscle from WT and PAGR1f/f/Hsa-Cre mice following intraperitoneal injection of an AKT inhibitor (AKTi-1/2, 50mg/kg for 2 days) or saline in.

  • 1/16

    AKT inhibitor VIII purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Aug 18;11(8):644. [Abstract]

    Customer Validation
     AKT inhibitor VIII (AKTi VIII; 20-80 μM; 24 h). CCK-8 assay was used to evaluate the effects of different concentration of AKTi VIII on the viability of ovarian cancer cells at 24 h.

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    AKT inhibitor VIII purchased from MedChemExpress. Usage Cited in: Nat Commun. 2018 Nov 19;9(1):4874. [Abstract]

    Customer Validation
     The expression of p-S6ser235/236 in splenic NK cells from control versus Rictor∆/∆ mice after treatment with DMSO or 2 μM AKTi-1/2 for 6 h ex vivo.

  • AKT inhibitor VIII