1. Screening Libraries
  2. PI3K/Akt/mTOR Compound Library

PI3K/Akt/mTOR Compound Library

Cat. No.: HY-L015
Library Contents: XLSX PDF SDF

The PI3K/Akt/mTOR pathway controls many cellular processes that are important for the formation and progression of cancer, including apoptosis, transcription, translation, metabolism, angiogenesis, and cell cycle progression. Every major node of this signaling network is activated in a wide range of human tumors. Mechanisms for the pathway activation include activation of receptor tyrosine kinases (RTKs) upstream of PI3K, mutation or amplification of PIK3CA encoding p110α catalytic subunit of PI3K, mutation or loss of PTEN tumor suppressor gene, and mutation or amplification of Akt1. Once the pathway is activated, signaling through Akt can stimulate a series of substrates including mTOR which is involved in protein synthesis. Thus, inhibition of this pathway is an attractive concept for cancer prevention and/or therapy. Currently some mTOR inhibitors are approved for several indications, and there are several novel PI3K/Akt/mTOR inhibitors in clinical trials.

MCE owns a unique collection of 308 compounds that can be used for PI3K/Akt/mTOR pathway research. PI3K/Akt/mTOR Compound Library also acts as a useful tool for anti-cancer drug discovery.

MCE PI3K/Akt/mTOR Compound Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 301 compounds supplied in 10 mM solution, 6 compounds supplied in 2 mM solution and 1 compounds supplied in 3 mg/mL solution.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

  • 96-well Plate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
Size (Pre-dissolved Solution or Solid) Price Stock
30 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

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50 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

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100 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

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2 × 100 μL/well Solution

10 mM , 2 mM and 3 mg/mL
Pre-dissolved Solution

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  • Description

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Description
& Advantages

•   A unique collection of 308 small molecule inhibitors used for PI3K/Akt/mTOR pathway research.

•   Targets such as Akt, AMPK, DNA-PK, PDK-1, mTOR, PI3K, PTEN, etc.

•   A valuable tool for studying PI3K/Akt/mTOR-related survival, proliferation, and apoptosis of cells and related diseases.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by the FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   Rich documentation with structure, IC50, and summary.

•   NMR and HPLC validated to ensure high purity.

•   All compounds are in stock and continuously updated.

Product Details
Formulation:
A collection of 308 PI3K/Akt/mTOR pathway related compounds supplied as pre-dissolved Solutions or Solid
Solution: 301 compounds supplied in 10 mM solution, 6 compounds supplied in 2 mM solution, 1 compounds supplied in 3 mg/mL solution.
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice
Composition

PI3K/Akt/mTOR Compound Library

Source: MedChem Express

Documentation

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    Product Name:
    PI3K/Akt/mTOR Compound Library
    Cat. No.:
    HY-L015
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack