2. Recombinant Proteins
  3. CAR-T related Proteins

CAR-T related Proteins

CAR-T related Proteins

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Chimeric antigen receptor T (CAR-T) cells, which are genetically engineered to express specific synthetic antigen receptors, can specifically target antigens and kill tumor cells. CAR-T cells are capable of specifically recognizing their target antigen through the single-chain fragment variable (scFv) binding domain, resulting in T cell activation in a major histocompatibility complex (MHC)-independent manner. Generally, CAR molecules are composed of 3 components: 1) an extracellular domain involved in antigen identification, which is composed of a scFv that (specifically) recognizes tumor-associated antigens (TAA). scFV is fixed on T cell by a 2) transmembrane domain, composed of a transmembrane region of CD3, CD8, CD28 or FcεRI. This region is connected to the 3) intracellular zone, composed of the intracytoplasmic region of CD8, CD28 or CD137 and CD3ζ. This zone comprises the immune receptor tyrosine-based activation motif (ITAM) which activates the costimulatory signal.

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