2. Disease Areas
  3. Inflammation or Immune System Disease
  4. Immunomodulation

Immunomodulation

Immunosuppression involves the deliberate reduction of immune system activity to prevent graft rejection in transplant patients, manage autoimmune diseases, or enable successful engraftment in allogeneic stem cell transplantation. It is primarily achieved through pharmacological agents that inhibit lymphocyte proliferation and activation, with combination therapies used to balance efficacy and minimize adverse effects. This strategy is particularly crucial in sensitized individuals or pediatric patients with heightened rejection risk, while also accounting for natural immunosuppressive mechanisms within the immune system itself.

 

Immunomodulation (21):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P6292A
    KS-133 TFA 98.95%
    KS-133 TFA is a highly selective and potent antagonist of the vascular active enteropeptide receptor 2 (VIPR2) with IC50 values for Ca influx measurement and cAMP measurement of 24.8 nM and 500 nM, respectively. KS-133 TFA reverses the tumor-promoting M2 phenotype of tumor-associated macrophages to the anti-tumor M1 phenotype, alters the tumor immune microenvironment, and inhibits tumor growth. KS-133 TFA can be used for research on schizophrenia and cancer immune regulation.
    KS-133 TFA
  • HY-B0199A
    Mycophenolate mofetil hydrochloride 116680-01-4 99.17%
    Mycophenolate mofetil (RS 61443; TM-MMF) hydrochloride is an orally active antimetabolic immunosuppressant with antiproliferative and anti-inflammatory properties. Mycophenolate mofetil hydrochloride significantly inhibits the production of B, T lymphocytes and the proliferation of smooth muscle cells by selectively blocking the de novo purine synthesis pathway. Mycophenolate mofetil hydrochloride effectively reduces adventitial inflammation, medial necrosis and intimal thickening in rat aortic allografts, and decreases the number of lymphocytes expressing the IL-2 receptor, thereby delaying xenograft rejection. Mycophenolate mofetil hydrochloride shows certain toxicity in a hamster-to-rat limb xenotransplantation model when used in combination with FK506 (HY-13756). Mycophenolate mofetil hydrochloride is widely used in studies related to allograft arteriosclerosis (chronic rejection).
    Mycophenolate mofetil hydrochloride
  • HY-121356
    Carebastine 90729-42-3 99.23%
    Carebastine is an Ebastine (HY-B0674) metabolite and H1-receptor antagonist. Carebastine inhibits VEGFR-2 and Akt phosphorylation. Carebastine exerts an anti-inflammatory effect by inhibiting MIF as well as TNF-α and IL-6 production. Carebastine shows anti-angiogenic activity
    Carebastine
  • HY-N7372
    Licoisoflavanone 66067-26-3
    Licoisoflavanone is an orally active isoflavane-based immunomodulator with multiple activities including antiviral, anti-inflammatory, cytoprotective and cancer cell apoptosis-inducing effects. Licoisoflavanone can be isolated from the roots and rhizomes of Glycyrrhiza uralensis Fisch. Licoisoflavanone not only enhances the body's immunity, but also effectively prevents acute respiratory distress syndrome and multiple organ damage by alleviating cytokine storm, thereby reducing the degree of inflammation. In rats, Licoisoflavanone undergoes multiple metabolic transformation processes such as glucuronidation, hydroxylation, sulfation, methylation and dehydrogenation. Licoisoflavanone has become an important candidate molecule for research on COVID-19 and related inflammatory diseases.
    Licoisoflavanone
  • HY-180559
    nAChR antagonist 2
    nAChR antagonist 2 is a selective nAChR antagonist. nAChR antagonist 2 inhibits nAChR subtype including hα9α10, hα9, and hα7 with IC50 values of 16.0 nM, 26.2 nM, and 336.3 nM, respectively, in Xenopus oocytes. nAChR antagonist 2 suppresses ATP-induced IL-1β release at nanomolar concentrations. nAChR antagonist 2 can be used for nonopioid analgesics and immunomodulators research.
    nAChR antagonist 2
  • HY-P11699
    AAPDNRETF 179953-98-1
    AAPDNRETF is a dominant minor histocompatibility antigen presented by H-2Db， which antigen is expressed in C57BL/6 mice and can be recognized by T cells from C3H.SW mice, thereby inducing a strong immune response. AAPDNRETF can induce graft-versus-host disease in irradiated C57BL/6 recipient mice via transfer of sensitized T lymphocytes. AAPDNRETF is applicable to the research of graft-versus-host disease.
    AAPDNRETF
  • HY-160824
    Neutrophil elastase-IN-7 6968-33-8
    Neutrophil elastase-IN-7 (Compound 12) is an effective inhibitor of neutrophil elastase (HNE), with an IC50 value of 0.54 μM. Neutrophil elastase-IN-7 also exhibits significant inhibitory activity against various coagulation proteins, with the IC50 values for thrombin, FXa, FXIa, and FXIIIa being 8.2, 12.7, 1.2, and 5.7 μM, respectively. Neutrophil elastase-IN-7 can be used for research on inflammation, innate immune responses, and tissue remodeling.
    Neutrophil elastase-IN-7
  • HY-W698462
    (S)-3-Hydroxymyristic acid 35683-15-9 99.73%
    (S)-3-Hydroxymyristic acid ((3S)-3-Hydroxytetradecanoic acid) is the enantiomer of (R)-3-hydroxytetradecanoic acid (a lipid A component) (HY-W288375), and enhances the inherent immune adjuvant activity of lipid A.
    (S)-3-Hydroxymyristic acid
  • HY-181472
    10(11)-Cl-BBQ
    10 (11)-Cl-BBQ is a high-affinity aryl hydrocarbon receptor (AhR) agonist. 10 (11)-Cl-BBQ is a mixture of 10-Cl-BBQ and 11-Cl-BBQ, among which 11-Cl-BBQ exhibits higher AhR activation potency than 10-Cl-BBQ. Low-dose/short-term AhR activation by 10 (11)-Cl-BBQ promotes IL-17 production, while high-dose/sustained activation induces regulatory T cells and suppresses immune responses. 10 (11)-Cl-BBQ can be used in immunomodulation research.
    10(11)-Cl-BBQ
  • HY-N17413
    (-)-γ-Cuparenol 1357469-94-3
    (-)-γ-Cuparenol is a sesquiterpene compound with an IC50 of 23.6 μg/mL against porcine Na+/K+-ATPase. (-)-γ-Cuparenol reduces phytohemagglutinin (PHA)-induced activation of NF-AT and NF-κB in Jurkat cells. (-)-γ-Cuparenol inhibits the growth of Gram-positive bacteria and some Gram-negative bacteria. (-)-γ-Cuparenol exhibits weak inhibitory activity against Candida albicans. (-)-γ-Cuparenol is applicable for research related to immunoregulation, cardiovascular diseases and bacterial infections.
    (-)-γ-Cuparenol
  • HY-N15163
    Saponin D 79190-14-0
    Saponin D is a natural product. Saponin D can be obtained from the leaves of Hovenia dulcis. The glycosidic bond of Saponin D is cleaved in an alkaline manner to yield Jujubogenin and Saponin G. A self-nanoemulsifying adjuvant with Saponin D boosts immune response and exerts an anti-lymphoma effect.
    Saponin D
  • HY-50876A
    Daporinad hydrochloride 2727965-45-7
    Daporinad (FK866) hydrochloride is a non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt), with a Ki value of 0.3 nM. Daporinad hydrochloride depletes NAD+ and ATP levels, inhibits mTORC1 and MAPK/ERK pathways, and activates TFEB to induce autophagy. Daporinad hydrochloride causes the depletion of the endoplasmic reticulum Ca²⁺ pool, ultimately weakening the mitogen-induced Ca²⁺ signal and the activation and function of T cells. Daporinad hydrochloride induces cell cycle arrest and apoptosis, and inhibits cell proliferation. Daporinad hydrochloride can be used for the study of myeloma, liver cancer, and immunosuppression.
    Daporinad hydrochloride
  • HY-171537
    TIM-3-ligand-1 2883237-01-0
    TIM-3-ligand-1 (Compound 35) is a highly efficient and selective TIM-3 ligand with a Ki value of 156 nM. TIM-3-ligand-1 can be used for research in immunotherapy.
    TIM-3-ligand-1
  • HY-W743767
    Mizoribine 5'-monophosphate 62025-48-3
    Mizoribine 5'-monophosphate (MZR-P) is the active metabolite of Mizoribine (HY-17470). Mizoribine 5'-monophosphate is an inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), and its Ki values for IMPDH of Trypanosoma brucei, Bacillus subtilis and Oceanobacillus iheyensis are 3.3, 72 and 157 nM respectively. Mizoribine 5'-monophosphate can be used in anti-trypanosomiasis and immunosuppression research.
    Mizoribine 5'-monophosphate
  • HY-P11479
    Cbl-b-IN-31 3029912-63-5
    Cbl-b-IN-31 (Compound Pep 1) is a Cbl-b inhibitor with a Kd of 0.42 μM. Cbl-b-IN-31 is inactive in cellular assays. Cbl-b-IN-31 can be used in the research of immune-mediated diseases.
    Cbl-b-IN-31
  • HY-180674
    LA24
    LA24 is a potent STING allosteric agonist, with an EC₅₀ of 0.82 μM. LA24 induces the phosphorylation of STING and IRF3. LA24 can be used for the study of STING-targeted immunotherapies.
    LA24
  • HY-180900
    Z3071585108 2249005-28-3
    Z3071585108 is a small molecule binder of the LAG-3 D1 domain with Kd values measured for the MST-TRIC channel and spectral shift detection of 59.2 and 56.1 μM respectively. Z3071585108 partially inhibits the binding of LAG-3 to MHCII, with an EC₅₀ of 42.9 μM. Z3071585108 can be used for the study of small molecule immunotherapies targeting LAG-3.
    Z3071585108
  • HY-100485
    Susalimod 149556-49-0
    Susalimod is an immunomodulating agent and Sulfasalazine (HY-14655) analogue. Susalimod decreases LPS-induced TNF-alpha mouse serum levels.
    Susalimod
  • HY-P11458
    Hanlp24
    Hanlp24 (Nlp24) is an immunogenic short peptide derived from plant pathogenic microorganisms. Hanlp24 can be recognized by the immune system of the model plant Arabidopsis thaliana and effectively induces the production of reactive oxygen species (ROS) in Arabidopsis thaliana. Hanlp24 is not the key factor that triggers plant defense and leads to the loss of pathogen virulence in the interaction system between cucumber and anthracnose pathogen. Hanlp24 can be used for the study of the plant immune system.
    Hanlp24
  • HY-P10427
    DV1
    DV1 is a CXCR4 inhibitor with anti-proteolytic properties that specifically blocks the binding of SDF-1α to its receptor. DV1 inhibits the migration of breast cancer cells and enables the targeted delivery of avidin-PLGA nanoparticles to CXCR4-expressing cancer cells. DV1 not only effectively suppresses the progression of metastatic breast cancer in mouse models, but also preferentially accumulates in brain tumor tissues rather than normal brain tissues, showing potential for inhibiting intracranial tumor metastasis. As a humoral immune stimulant, DV1 induces the production of specific IgG, neutralizing antibodies and cellular immune responses, thereby providing the host with protection against lethal challenges. DV1 has been applied to studies on CXCR4-expressing cancers, glioblastoma, dengue fever and other related diseases.
    DV1