1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Ebastine

Ebastine (Synonyms: LAS-W 090; RP64305)

Cat. No.: HY-B0674 Purity: 99.96%
Handling Instructions

Ebastine(LAS-W 090;RP64305) is a long-acting and selective H1-histamine receptor antagonist.

For research use only. We do not sell to patients.

Ebastine Chemical Structure

Ebastine Chemical Structure

CAS No. : 90729-43-4

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
500 mg USD 60 In-stock
Estimated Time of Arrival: December 31
1 g USD 84 In-stock
Estimated Time of Arrival: December 31
5 g USD 300 In-stock
Estimated Time of Arrival: December 31
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50 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Ebastine(LAS-W 090;RP64305) is a long-acting and selective H1-histamine receptor antagonist. Target: Histamine H1 Receptor Ebastine is a H1 antihistamine with low potential for causing drowsiness. Ebastine (10 mg orally) causes brain histamine H1-receptor occupation of approximately 10%, consistent with its lower incidence of sedative effect, whereas (+)-chlorpheniramine occupied about 50% of brain H1-receptors even at a low but sedative dose of 2 mg; occupancy of (+)-chlorpheniramine was correlated with plasma (+)-chlorpheniramine concentration [1]. ebastine 10 or 20 mg once daily was rapidly effective in relieving symptoms of PAR in adult and adolescent patients; additional benefits of the 20-mg dose became apparent in the longer term [2]. ebastine is an effective and generally well-tolerated treatment for allergic rhinitis and chronic idiopathic urticaria. In addition to the regular tablet formulation, ebastine is available as a FDT, providing a treatment option that is particularly convenient for patients [3].

Clinical Trial
Molecular Weight

469.66

Formula

C₃₂H₃₉NO₂

CAS No.

90729-43-4

SMILES

O=C(C1=CC=C(C(C)(C)C)C=C1)CCCN2CCC(OC(C3=CC=CC=C3)C4=CC=CC=C4)CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 58.75 mg/mL (125.09 mM; Need ultrasonic)

DMSO : 8.33 mg/mL (17.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1292 mL 10.6460 mL 21.2920 mL
5 mM 0.4258 mL 2.1292 mL 4.2584 mL
10 mM 0.2129 mL 1.0646 mL 2.1292 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

EbastineLAS-W 090 RP64305RP64305RP 64305RP-64305Histamine ReceptorInhibitorinhibitorinhibit

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Ebastine
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