VAV1
VAV1 is a hematopoietic signal transducer that possesses a GDP/GTP nucleotide exchange factor (GEF) that is tightly regulated by tyrosine phosphorylation, along with adapter protein domains, such as SH2 and SH3. VAV1 is identified as a mutated gene in human cancers of various origins.
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VAV1 Related Products (8)
Related Products (8)
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MRT-6160
0 ImagesSynonyms: VAV1 degrader-3MRT-6160 (Example 185) is an orally active VAV1 molecular glue degrader (DC50: 7 nM). MRT-6160 reduces immune cell activation, immune cell proliferation and the production of various cytokines. MRT-6160 can be used for research of inflammatory or autoimmune disorder. MRT-6160 inhibits disease progression in experimntal autoimmune encephalomyelitis (EAE) mouse model, Collagen-induced arthritis (CIA) mouse model, etc..
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6-Thio-GTP tetrasodium
0 ImagesCat. No.: HY-131598CPurity: 99.7%Synonyms: 6-Thioguanosine-5'-triphosphate tetrasodium6-Thio-GTP (tetrasodium) is a Vav1-Rac inhibitor. 6-Thio-GTP (tetrasodium) inhibits TCR-stimulated T cell proliferation and CD28-mediated T cell survival. 6-Thio-GTP (tetrasodium) has an immunosuppressive effect in a mouse cardiac allograft transplant model and prolongs cardiac allograft survival.
The product specifications provided below refer solely to the active content of 6-Thio-GTP tetrasodium.
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VAV1 degrader-2
0 ImagesVAV1 degrader-2 is a molecular glue degrader based on targeting Vav guanine nucleotide exchange factor 1 (VAV 1) with a DC50 of 4.41 nM. VAV1 degrader-2 can be used in the study of inflammatory and autoimmune diseases.
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MRT-23227
0 ImagesMRT-23227 is a CRBN-recruiting molecular glue degrader targeting VAV1. MRT-23227 binds to the tryptophan triad pocket of CRBN, forms a ternary complex with the SH3c domain of VAV1, and induces proteasomal degradation of VAV1 through hydrogen-bond interactions between CRBN residues and the RT loop and side chains of VAV1. MRT-23227 can be used in the research of T-cell leukemia and lymphoma.
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AB19
0 ImagesCat. No.: HY-179119AB19 is a potent Vav1 inhibitor. AB19 inhibits Vav1 and reduces its downstream ERK phosphorylation. AB19 shows anti-proliferative activity in pancreatic cancer models. AB19 can be used for pancreatic cancer research.
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(R)-MRT-6160
0 ImagesCat. No.: HY-164773CAS No.: 3050683-63-8(R)-MRT-6160 is a molecular glue degrader targeting VAV1, with a DC50 of 40.93 nM. (R)-MRT-6160 induces VAV1 ubiquitination and proteasomal degradation by forming a CRBN-(R)-MRT-6160-VAV1 ternary complex, thereby inhibiting signaling downstream of the T/B cell receptor. (R)-MRT-6160 can be used in leukemia-related research.
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VAV1 degrader-4
0 ImagesCat. No.: HY-182765CAS No.: 3119457-09-6VAV1 degrader-4 is a VAV1 molecular glue degrader with a DC50 value of 3.93 nM for VAV1 in Jurkat cells. VAV1 degrader-4 can dose-dependently inhibit the production of IL-2. VAV1 degrader-4 can be used for research on autoimmune diseases.
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(S)-VAV1 degrader-1
0 ImagesCat. No.: HY-W1118851CAS No.: 3050683-64-9(S)-VAV1 degrader-1 is a VAV1 molecular glue degrader with DC50 = 3.07 nM. (S)-VAV1 degrader-1 is used for research on VAV1-related diseases, such as inflammation and immune-related diseases.
